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New-onset cardiac rhabdomyoma beyond infancy in a patient with tuberous sclerosis complex

Published online by Cambridge University Press:  14 July 2015

Nikhil M. Thatte Open the ORCID record for Nikhil M. Thatte [Opens in a new window] ,
Kristine J. Guleserian  and
Surendranath R. Veeram Reddy
Nikhil M. Thatte*
Affiliation:
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
Kristine J. Guleserian
Affiliation:
Division of Pediatric Cardiothoracic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
Surendranath R. Veeram Reddy
Affiliation:
Division of Cardiology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
*
Correspondence to: N. Thatte, MD, University of Texas Southwestern Medical Center/Children’s Medical Center, 1935 Medical District Drive, Dallas, Texas 75235, United States of America. Tel: +1-214-456-5518; Fax: +1-214-456-2625; E-mail: Nikhil.Thatte@Childrens.com
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Abstract

Cardiac rhabdomyomas in patients with tuberous sclerosis complex are usually detected antenatally or during infancy, with subsequent stabilisation or spontaneous regression. Development of a new cardiac rhabdomyoma beyond infancy is very rare. We report a male child who needed resection of a large rhabdomyoma in neonatal life, and then developed a new-onset rhabdomyoma at 2 years of age in a different location, needing another resection. Routine surveillance for cardiac rhabdomyomas in asymptomatic patients with tuberous sclerosis is essential.

Keywords

Cardiac tumoursrhabdomyomatuberous sclerosisnatural history
Type
Brief Reports
Information
Cardiology in the Young , Volume 26 , Issue 2 , February 2016 , pp. 396 - 399
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Copyright
© Cambridge University Press 2015 

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References

1. Jóźwiak, S, Kotulska, K, Kasprzyk-Obara, J, et al. Clinical and genotype studies of cardiac tumors in 154 patients with tuberous sclerosis complex. Pediatrics 2006; 118: e1146–e1151.CrossRefGoogle ScholarPubMed
2. DiMario, FJ, Diana, D, Leopold, H, Chameides, L. Evolution of cardiac rhabdomyoma in tuberous sclerosis complex. Clin Pediatr (Phila) 1996; 35: 615–619.CrossRefGoogle ScholarPubMed
3. Farooki, ZQ, Ross, RD, Paridon, SM, Humes, RA, Karpawich, PP, Pinsky, WW. Spontaneous regression of cardiac rhabdomyoma. Am J Cardiol 1991; 67: 897–899.Google Scholar
4. Nir, A, Tajik, AJ, Freeman, WK, et al. Tuberous sclerosis and cardiac rhabdomyoma. Am J Cardiol 1995; 76: 419–421.CrossRefGoogle ScholarPubMed
5. Sciacca, P, Giacchi, V, Mattia, C, et al. Rhabdomyomas and tuberous sclerosis complex: our experience in 33 cases. BMC Cardiovasc Disord 2014; 14: 66.CrossRefGoogle ScholarPubMed
6. Smythe, JF, Dyck, JD, Smallhorn, JF, Freedom, RM. Natural history of cardiac rhabdomyoma in infancy and childhood. Am J Cardiol 1990; 66: 1247–1249.Google Scholar
7. Bosi, G, Lintermans, JP, Pellegrino, PA, Svaluto-Moreolo, G, Vliers, A. The natural history of cardiac rhabdomyoma with and without tuberous sclerosis. Acta Paediatr 1996; 85: 928–931.CrossRefGoogle ScholarPubMed
8. Jozwiak, J, Jozwiak, S, Wlodarski, P. Possible mechanisms of disease development in tuberous sclerosis. Lancet Oncol 2008; 9: 73–79.CrossRefGoogle ScholarPubMed
9. Kotulska, K, Larysz-Brysz, M, Grajkowska, W, et al. Cardiac rhabdomyomas in tuberous sclerosis complex show apoptosis regulation and mTOR pathway abnormalities. Pediatr Dev Pathol 2009; 12: 89–95.CrossRefGoogle ScholarPubMed
10. Schwartz, RA, Fernández, G, Kotulska, K, Jóźwiak, S. Tuberous sclerosis complex: advances in diagnosis, genetics, and management. J Am Acad Dermatol 2007; 57: 189–202.CrossRefGoogle ScholarPubMed