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Outcomes of cardiac surgery in trisomy 18 patients

Published online by Cambridge University Press:  21 December 2010

Jun Muneuchi ,
Junko Yamamoto ,
Yasuhiko Takahashi ,
Mamie Watanabe ,
Tetsuji Yuge ,
Takuro Ohno ,
Yutaka Imoto ,
Akira Sese  and
Kunitaka Joo
Jun Muneuchi*
Affiliation:
Department of Pediatrics, Kyushu Koseinenkin Hospital, Kishinoura, Yahatanishi-ku, Kitakyushu, Fukuoka, Japan
Junko Yamamoto
Affiliation:
Department of Pediatrics, Kyushu Koseinenkin Hospital, Kishinoura, Yahatanishi-ku, Kitakyushu, Fukuoka, Japan
Yasuhiko Takahashi
Affiliation:
Department of Pediatrics, Kyushu Koseinenkin Hospital, Kishinoura, Yahatanishi-ku, Kitakyushu, Fukuoka, Japan
Mamie Watanabe
Affiliation:
Department of Pediatrics, Kyushu Koseinenkin Hospital, Kishinoura, Yahatanishi-ku, Kitakyushu, Fukuoka, Japan
Tetsuji Yuge
Affiliation:
Department of Pediatrics, Kyushu Koseinenkin Hospital, Kishinoura, Yahatanishi-ku, Kitakyushu, Fukuoka, Japan
Takuro Ohno
Affiliation:
Department of Pediatrics, Kyushu Koseinenkin Hospital, Kishinoura, Yahatanishi-ku, Kitakyushu, Fukuoka, Japan
Yutaka Imoto
Affiliation:
Department of Cardiovascular Surgery, Kyushu Koseinenkin Hospital, Kishinoura, Yahatanishi-ku, Kitakyushu, Fukuoka, Japan
Akira Sese
Affiliation:
Department of Cardiovascular Surgery, Kyushu Koseinenkin Hospital, Kishinoura, Yahatanishi-ku, Kitakyushu, Fukuoka, Japan
Kunitaka Joo
Affiliation:
Department of Pediatrics, Kyushu Koseinenkin Hospital, Kishinoura, Yahatanishi-ku, Kitakyushu, Fukuoka, Japan
*
Corresponding to: Dr J. Muneuchi, Division of Pediatrics, Kyushu Koseinenkin Hospital, 1-8-1, Kishinoura, Yahatanishi-ku, Kitakyushu, Fukuoka 806-8501, Japan. Tel: +81 93 641 5111; Fax: +81 93 642 1868; E-mail: mune@pediatr.med.kyushu-u.ac.jp
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Abstract

Objective

The objective was to clarify the outcomes of cardiac surgery in trisomy 18 patients.

Patients and methods

We analysed 34 consecutive trisomy 18 patients, of whom 21 were males, with cardiac complications. They were divided into patients who underwent cardiac surgery and those who were conservatively treated. We compared rates of survival and discharge alive between two groups.

Results

The surgery group included nine patients, with six males, who underwent cardiac surgery – intracardiac repair in three patients, pulmonary arterial banding in five patients, and ligation of the ductus in one patient – at median age of 2.2 months, ranging from 0.5 to 9.8, and with median weight of 2.6 kilograms, ranging from 1.5 to 3.2. Cardiac surgery and pre-operative assisted ventilation were hazardous factors leading to death. In the surgery group, cumulative survival rates at 1 month, 6 months, 12 months, and 24 months were 63%, 38%, 25%, and 22%, respectively, compared with 51%, 26%, 9%, and 9% in the conservative group. There was a significant difference (p = 0.002). The cumulative rates of discharge alive at 1 month, 3 months, and 6 months were 0%, 12%, and 65% in the surgery group, which did not differ from the conservative group (p = 0.80).

Conclusions

Cardiac surgery contributed to increased survival rate but not the rate of discharge alive in trisomy 18 patients. Cardiac surgery could not prevent all the trisomy 18 patients from death. The indication of cardiac surgery should be carefully individualised to improve the quality of life in trisomy 18 patients and concerned surrounding people.

Keywords

Trisomy 18cardiac surgeryoutcomecongenital cardiac diseasecentral apnoea
Type
Original Articles
Information
Cardiology in the Young , Volume 21 , Issue 2 , April 2011 , pp. 209 - 215
Copyright
Copyright © Cambridge University Press 2010

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