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Oxygen free radicals in children with acute rheumatic fever

Published online by Cambridge University Press:  15 August 2006

Bülent Oran ,
Emre Atabek ,
Sevim Karaaslan ,
Ýsmail Reisli ,
Fatih Gültekin  and
Ýbrahim Erkul
Bülent Oran
Affiliation:
Department of Pediatrics, Selçuk University, Konya, Turkey
Emre Atabek
Affiliation:
Department of Pediatrics, Selçuk University, Konya, Turkey
Sevim Karaaslan
Affiliation:
Department of Pediatrics, Selçuk University, Konya, Turkey
Ýsmail Reisli
Affiliation:
Department of Pediatrics, Selçuk University, Konya, Turkey
Fatih Gültekin
Affiliation:
Biochemistry, School of Medicine, Selçuk University, Konya, Turkey
Ýbrahim Erkul
Affiliation:
Department of Pediatrics, Selçuk University, Konya, Turkey
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Abstract

We have investigated the relationship between oxygen free radicals and acute rheumatic fever with regard to diagnosis of the disease process. At the time of diagnosis, we measured the levels of reactive oxygen molecules in the plasma, this being a parameter for oxygen free radicals, and discovered the levels to be significantly higher when compared with those measured in a control group (P< 0.05). The levels measured in the plasma, however, were not statistically different among patients with and without carditis.

We found a progressive decrease in the levels measured in the plasma when patients with acute rheumatic fever were tested on the 15th, 30th and 90th days subsequent to diagnosis. By the 90th day, levels measured in the plasma were still higher, but no longer significantly elevated, when compared with the control group. The present study is preliminary, but raises the possibility that measurement of oxygen free radicals in the plasma could be used as a laboratory test for active state of acute rheumatic fever. Further investigations will be needed, nonetheless, to determine the clinical application of this technique.

Keywords

Acute rheumatic feveroxygen free radicalsreactive oxygen moleculesGroup A β hemolytic Streptococcus
Type
Original Article
Information
Cardiology in the Young , Volume 11 , Issue 3 , May 2001 , pp. 285 - 288
Copyright
2001 Cambridge University Press

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