Hostname: page-component-cd9895bd7-jkksz Total loading time: 0 Render date: 2024-12-26T17:51:25.987Z Has data issue: false hasContentIssue false
  • English
  • Français

Periodic fever syndromes: a patient diagnosed with recurrent Kawasaki disease

Published online by Cambridge University Press:  11 June 2020

Sena Turk Open the ORCID record for Sena Turk [Opens in a new window] ,
Derya Aydin ,
Eser Dogan ,
Erturk Levent  and
Necil Kutukculer
Sena Turk*
Affiliation:
Department of Pediatric Cardiology, Faculty of Medicine, Ege University, Izmir, Turkey
Derya Aydin
Affiliation:
Department of Pediatric Cardiology, Faculty of Medicine, Ege University, Izmir, Turkey
Eser Dogan
Affiliation:
Department of Pediatric Cardiology, Faculty of Medicine, Ege University, Izmir, Turkey
Erturk Levent
Affiliation:
Department of Pediatric Cardiology, Faculty of Medicine, Ege University, Izmir, Turkey
Necil Kutukculer
Affiliation:
Department of Pediatric Immunology, Faculty of Medicine, Ege University, Izmir, Turkey
*
Author for correspondence: Sena Turk, MD, Department of Pediatric Cardiology, Ege University Children’s Hospital, Bornova, Izmir35100, Turkey. Tel: +905068299148; Fax: +902323901357. E-mail: drsenaturk@gmail.com
Get access Rights & Permissions [Opens in a new window]

Abstract

Kawasaki disease, known as mucocutaneous lymph node syndrome, is a multi-system disease of unknown aetiology that occurs in young children under 5 years of age. The recurrence rate of Kawasaki disease is as rare as 1–3%. Especially in cases with coronary artery involvement, recurrent Kawasaki disease should be investigated in terms of underlying rheumatologic diseases such as periodic fever syndromes, microscopic polyangiitis, polyarteritis nodosa, and systemic-onset juvenile arthritis. In this study, we report homozygote mutations in mevalonate kinase and familial Mediterranean fever genes in a recurrent Kawasaki disease with coronary dilatation.

Keywords

Familial Mediterranean feverhyperimmunoglobulin D syndromeKawasaki diseaseperiodic fever syndromes
Type
Original Article
Information
Cardiology in the Young , Volume 30 , Issue 7 , July 2020 , pp. 1009 - 1011
Copyright
© The Author(s), 2020. Published by Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Marrani, E, Burns, JC, Cimaz, R.How should we classify Kawasaki disease? Front Immunol 2018; 9: 2974.10.3389/fimmu.2018.02974CrossRefGoogle ScholarPubMed
Nakamura, Y, Oki, I, Tanihara, S, Ojima, T, Yanagawa, H.Cardiac sequelae in recurrent cases of Kawasaki disease: a comparison between the initial episode of the disease and a recurrence in the same patients. Pediatrics 1998; 102: E66.10.1542/peds.102.6.e66CrossRefGoogle Scholar
Kato, H, Sugimura, T, Akagi, T, Sato, N, Hashino, K, Maeno, Y, Kazue, T, Eto, G, Yamakawa, R.Long-term consequences of Kawasaki disease. A 10- to 21-year follow-up study of 594 patients. Circulation 1996; 94: 1379–1385.10.1161/01.CIR.94.6.1379CrossRefGoogle ScholarPubMed
Galeotti, C, Bayry, J, Kone-Paut, I, Kaveri, SV.Kawasaki disease: aetiopathogenesis and therapeutic utility of intravenous immunoglobulin. Autoimmun Rev 2010; 6: 441–448.10.1016/j.autrev.2009.12.004CrossRefGoogle Scholar
Mavrogeni, S, Manoussakis, MN, Karagiorga, TC, et al.Detection of coronary artery lesions and myocardial necrosis by magnetic resonance in systemic necrotizing vasculitides. Arthritis Rheu 2009; 61: 1121–1129.10.1002/art.24695CrossRefGoogle ScholarPubMed
Kumar, S, Vaidyanathan, B, Gayathri, S, Rajam, L.Systemic onset juvenile idiopathic arthritis with macrophage activation syndrome misdiagnosed as Kawasaki disease: case report and literature review. Rheumatol Int 2013; 33: 1065–1069.CrossRefGoogle ScholarPubMed
Broderick, L, Tremoulet, AH, Burns, JC, Bastian, JF, Hoffman, HM.Recurrent fever syndromes in patients after recovery from Kawasaki syndrome. Pediatrics 2011; 127: e489–e493.CrossRefGoogle ScholarPubMed
Thors, VS, Vastert, SJ, Wulffraat, N, et al.Periodic fever in MVK deficiency: a patient initially diagnosed with incomplete Kawasaki disease. Pediatrics 2014; 133: e461–e465.10.1542/peds.2012-1372CrossRefGoogle ScholarPubMed
Cuisset, L, Drenth, JP, Simon, A, et al.Molecular analysis of MVK mutations and enzymatic activity in hyper-IgD and periodic fever syndrome. Eur J Hum Genet 2001; 9: 260–266.10.1038/sj.ejhg.5200614CrossRefGoogle ScholarPubMed
Çeliksoy, MH, Berdeli, A, Comba, A, Çaltepe, G, Yıldıran, A.Severe hyper IgD syndrome associated with heterozygote S52N mevalonate kinase mutation. Asthma Allergy Immunol 2017; 15: 111–114.10.21911/aai.5022CrossRefGoogle Scholar
Ozen, S, Bakkaloglu, A, Yilmaz, E, et al.Mutations in the gene for familial Mediterranean fever: do they predispose to inflammation. J Rheumatol 2003; 30: 2014–2018.Google Scholar
Yamaguchi, K, Ikeda, K, Ihara, K, Takada, H, Kusuhara, K, Hara, T.Lack of association between E148Q MEFV variant and Kawasaki disease. Hum Immunol 2009; 70: 468–471.10.1016/j.humimm.2008.10.017CrossRefGoogle ScholarPubMed
Cankaya, T, Bora, E, Torun, M, Ulgenalp, A, Kavukcu, S, Turkmen, M, Soylu, A.Clinical significance of R202Q alteration of MEFV gene in children with familial Mediterranean fever. Arch Rheumatol 2015; 30: 51–56.CrossRefGoogle Scholar