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Physiological changes in blood pressure impact peripheral endothelial function during adolescence

Published online by Cambridge University Press:  16 June 2014

Livia Deda ,
Etienne B. Sochett  and
Farid H. Mahmud
Livia Deda
Affiliation:
Department of Endocrinology, Hospital for Sick Children, University of Toronto, Ontario, Canada
Etienne B. Sochett
Affiliation:
Department of Endocrinology, Hospital for Sick Children, University of Toronto, Ontario, Canada Faculty of Medicine, Department of Pediatrics, University of Toronto, Ontario, Canada
Farid H. Mahmud*
Affiliation:
Department of Endocrinology, Hospital for Sick Children, University of Toronto, Ontario, Canada Faculty of Medicine, Department of Pediatrics, University of Toronto, Ontario, Canada
*
Correspondence to: Dr F. H. Mahmud MD, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1×8. Tel: 416-813-6218; Fax: 416-813-6304; E-mail: farid.mahmud@sickkids.ca
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Abstract

Reactive hyperemia index is a measure of endothelial function used to assess subclinical atherosclerosis. When evaluated in healthy adolescents, significant changes in endothelial function were correlated with advancing age, pubertal status, and blood pressure. Blood pressure was the principal contributor to reactive hyperemia index variability independent of age, lipid profile, body mass index, and/or pubertal status. Interpretation of this peripheral vascular marker should include age and maturational changes in paediatric patients.

Keywords

Diabetesadolescentsendothelial functionreactive hyperemia index
Type
Brief Reports
Information
Cardiology in the Young , Volume 25 , Issue 4 , April 2015 , pp. 777 - 779
Copyright
© Cambridge University Press 2014 

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