Hostname: page-component-78c5997874-lj6df Total loading time: 0 Render date: 2024-11-10T06:06:47.713Z Has data issue: false hasContentIssue false
  • English
  • Français

Plasma gelsolin as a biomarker of acute rheumatic carditis

Published online by Cambridge University Press:  18 November 2014

Mustafa Argun ,
Ali Baykan ,
Figen Narin ,
Abdullah Özyurt ,
Özge Pamukçu ,
Ferhan Elmalı ,
Kazım Üzüm  and
Nazmi Narin
Mustafa Argun*
Affiliation:
Department of Pediatrics, Division of Pediatric Cardiology, Erciyes University Medical Faculty, Kayseri, Turkey
Ali Baykan
Affiliation:
Department of Pediatrics, Division of Pediatric Cardiology, Erciyes University Medical Faculty, Kayseri, Turkey
Figen Narin
Affiliation:
Department of Medical Biochemistry, Erciyes University Medical Faculty, Kayseri, Turkey
Abdullah Özyurt
Affiliation:
Department of Pediatrics, Division of Pediatric Cardiology, Erciyes University Medical Faculty, Kayseri, Turkey
Özge Pamukçu
Affiliation:
Department of Pediatrics, Division of Pediatric Cardiology, Erciyes University Medical Faculty, Kayseri, Turkey
Ferhan Elmalı
Affiliation:
Department of Biostatistics and Medical Informatics, Erciyes University Medical Faculty, Kayseri, Turkey
Kazım Üzüm
Affiliation:
Department of Pediatrics, Division of Pediatric Cardiology, Erciyes University Medical Faculty, Kayseri, Turkey
Nazmi Narin
Affiliation:
Department of Pediatrics, Division of Pediatric Cardiology, Erciyes University Medical Faculty, Kayseri, Turkey
*
Correspondence to: M. Argun, MD, Department of Pediatrics, Erciyes University Medical Faculty, 38039 Kayseri, Turkey. Tel: +90 352 207 6666; Fax: +90 352 437 5825; E-mail: dr.margun@hotmail
Get access Rights & Permissions [Opens in a new window]

Abstract

Background

Acute rheumatic fever is an autoimmune, inflammatory, and multi-systemic disease secondary to pharyngitis and is caused by group A streptococcus. In developing countries, acute rheumatic fever is the most common cause of acquired heart disease. Gelsolin is a calcium-dependent, multi-functional actin-regulatory protein circulating in the plasma of healthy human beings. The correlation between blood gelsolin levels and inflammatory conditions suggests the potential benefit of gelsolin as a prognostic marker. The aim of the present study was to appraise the association of gelsolin and acute rheumatic carditis in childhood.

Materials and Methods

Plasma gelsolin levels were measured and echocardiographic examinations were performed in patients (n=37) with acute rheumatic carditis and compared with those of age- and gender-matched healthy controls (n=24).

Results

The plasma gelsolin levels in children with acute rheumatic carditis were significantly lower compared with controls (197±218 versus 322±255 mg/L, p=0.039). There was a significant correlation among gelsolin levels and the grade of mitral regurgitation (p=0.030), left ventricular end-diastolic diameter (p=0.017), and left ventricular end-systolic diameter (p=0.028) at diagnosis.

Conclusions

Levels of the gelsolin plasma isoform were decreased in patients with acute rheumatic carditis compared with healthy controls. Gelsolin may be used as a biochemical marker for acute rheumatic carditis.

Keywords

Acute rheumatic carditisgelsolinbiomarkerchildren
Type
Original Articles
Information
Cardiology in the Young , Volume 25 , Issue 7 , October 2015 , pp. 1276 - 1280
Check for updates
Copyright
© Cambridge University Press 2014 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Marijon, E, Mirabel, M, Celermajer, DS, Jouven, X. Rheumatic heart disease. Lancet 2012; 379: 953–964.Google Scholar
2. Esen, F, Argun, M, Pamukçu, O, et al. Importance of N-terminal pro-brain natriuretic peptide in monitoring acute rheumatic carditis. Cardiol Young 2013; 28: 1–5.Google Scholar
3. Bucki, R, Byfield, FJ, Kulakowska, A, et al. Extracellular gelsolin binds lipoteichoic acid and modulates cellular response to proinflammatory bacterial wall component. J Immunol 2008; 181: 4936–4944.CrossRefGoogle Scholar
4. Wang, H, Cheng, B, Chen, Q, et al. Time course of plasma gelsolin concentrations during severe sepsis in critically ill surgical patients. Crit Care 2008; 12: 1–6.CrossRefGoogle ScholarPubMed
5. Lee, PS, Drager, LR, Stossel, TP, Moore, FD, Rogers, SO. Relationship of plasma gelsolin levels to outcomes in critically ill surgical patients. Ann Surg 2006; 243: 399–403.Google Scholar
6. DiNubile, MJ. Plasma gelsolin as a biomarker of inflammation. Arthritis Res Ther 2008; 10: 124.Google Scholar
7. Peddada, N, Sagar, A, Ashish, GR, et al. Plasma gelsolin: a general prognostic marker of health. Med Hypotheses 2012; 78: 203–210.CrossRefGoogle ScholarPubMed
8. Dajani, AS, Ayoub, E, Bierman, FZ, et al. Guidelines for the diagnosis of rheumatic fever: Jones criteria, 1992 update. Special writing group of the committee on rheumatic fever, endocarditis, and Kawasaki disease of the council on cardiovascular disease in the young of the American Heart Association. JAMA 1992; 268: 2069–2073.CrossRefGoogle Scholar
9. WHO. Rheumatic fever and rheumatic heart disease. World Health Organ Tech Rep Ser 2004; 923: 1–122.Google Scholar
10. Lee, JF, Naguwa, SM, Cheema, GS, Gershwin, ME. Acute rheumatic fever and its consequences: a persistent threat to developing nations in the 21st century. Autoimmun Rev 2009; 9: 117–123.Google Scholar
11. Guilherma, L, Kalil, J. Rheumatic fever and rheumatic heart disease: cellular mechanisms leading autoimmune reactivity and disease. J Clin Immunol 2010; 30: 17–23.Google Scholar
12. Narin, N, Kütükçüler, N, Ozyürek, R, Bakiler, AR, Parlar, A, Arcasoy, M. Lymphocyte subsets and plasma IL-1 alpha, IL-2, and TNF-alpha concentrations in acute rheumatic fever and chronic rheumatic heart disease. Clin Immunol Immunopathol 1995; 77: 172–176.Google Scholar
13. Kütükçüler, N, Narin, N. Plasma interleukin-7 (IL-7) and IL-8 concentrations in acute rheumatic fever and chronic rheumatic heart disease. Scand J Rheumatol 1995; 24: 383–385.Google Scholar
14. Haddad, JG, Harper, KD, Guoth, M, Pietra, GG, Sanger, JW. Angiopathic consequences of saturating the plasma scavenger system for actin. Proc Natl Acad Sci USA 1990; 87: 1381–1385.CrossRefGoogle ScholarPubMed
15. Erukhimov, JA, Tang, ZL, Johnson, BA, et al. Actin-containing sera from patients with adult respiratory distress syndrome are toxic to sheep pulmonary endothelial cells. Am J Respir Crit Care Med 2000; 162: 288–294.CrossRefGoogle ScholarPubMed
16. Cohen, TS, Bucki, R, Byfield, FJ, et al. Therapeutic potential of plasma gelsolin administration in a rat model of sepsis. Cytokine 2011; 54: 235–238.CrossRefGoogle Scholar
17. Osborn, TM, Verdrengh, M, Stossel, TP, Tarkowski, A, Bokarewa, M. Decreased levels of the gelsolin plasma isoform in patients with rheumatoid arthritis. Arthritis Res Ther 2008; 10: R117.Google Scholar
18. Hu, YL, Li, H, Li, WH, et al. The value of decreased plasma gelsolin levels in patients with systemic lupus erythematosus and rheumatoid arthritis in diagnosis and disease activity evaluation. Lupus 2013; 22: 1455–1461.Google Scholar