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Post-operative Brugada electrocardiographic pattern, polymorphic ventricular tachycardia, and sudden death in a child after administration of propofol anaesthesia

Published online by Cambridge University Press:  27 March 2020

Duygu Uzun ,
Nimra Hassan  and
Utkarsh Kohli Open the ORCID record for Utkarsh Kohli [Opens in a new window]
Duygu Uzun
Affiliation:
Department of Pediatrics, Division of Pediatric Cardiology, St. John Hospital Medical Center, Detroit, MI, USA
Nimra Hassan
Affiliation:
Department of Pediatrics, Division of Pediatric Cardiology, St. John Hospital Medical Center, Detroit, MI, USA
Utkarsh Kohli*
Affiliation:
Department of Pediatrics, Division of Pediatric Cardiology, St. John Hospital Medical Center, Detroit, MI, USA Department of Pediatrics, Division of Pediatric Cardiology, The University of Chicago Pritzker School of Medicine, Chicago, IL, USA
*
Author for correspondence: U. Kohli, MD, Department of Pediatrics, Division of Pediatric Cardiology, The University of Chicago Pritzker School of Medicine, 5721 S Maryland Ave., MC 4051, Chicago, IL60637, USA. Tel: +1 773 702 6172; Fax: 773-702-2319; E-mail: ukohli@peds.bsd.uchicago.edu
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Abstract

A 9-year-old African-American girl presented with sudden cardiac arrest a few hours after adenotonsillectomy. She received anaesthesia which included propofol during the procedure. Her electrocardiogram (EKG) showed type 1 Brugada pattern, and genetic testing revealed a variant of unknown significance in desmoplakin (DSP) gene. We discuss the association between propofol, Brugada EKG pattern, and malignant ventricular arrhythmias.

Keywords

PropofolBrugada syndromesudden cardiac arrest
Type
Brief Report
Information
Cardiology in the Young , Volume 30 , Issue 5 , May 2020 , pp. 724 - 727
Copyright
© The Author(s) 2020. Published by Cambridge University Press

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