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Predictive value of red blood cell distribution width for coronary artery lesions in patients with Kawasaki disease

Published online by Cambridge University Press:  05 October 2015

Haiyan Xu ,
Songling Fu ,
Wei Wang ,
Qing Zhang ,
Jian Hu ,
Lichao Gao ,
Weihua Zhu  and
Fangqi Gong
Haiyan Xu
Affiliation:
Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, PR China
Songling Fu
Affiliation:
Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, PR China
Wei Wang
Affiliation:
Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, PR China
Qing Zhang
Affiliation:
Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, PR China
Jian Hu
Affiliation:
Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, PR China
Lichao Gao
Affiliation:
Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, PR China
Weihua Zhu
Affiliation:
Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, PR China
Fangqi Gong*
Affiliation:
Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, PR China
*
Correspondence to: Dr F. Gong, PhD, MD Children’s Hospital, Zhejiang University School of Medicine, No.57, Zhugan Lane, Hangzhou 310003, PR China. Tel: +86-571-87073271, Fax: +86-571-87033296, E-mail: gongfangqi@zju.edu.cn
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Abstract

Recent studies have shown that elevated red blood cell distribution width is associated with poor outcome in cardiovascular diseases. In order to assess the predictive value of red blood cell distribution width, before treatment with intravenous immunoglobulins, for coronary artery lesions in patient with Kawasaki disease, we compared 83 patients with coronary artery lesions and 339 patients without coronary artery lesions before treatment with intravenous immunoglobulin. Clinical, echocardiographic, and biochemical values were evaluated along with red blood cell distribution width. A total of 422 consecutive patients with Kawasaki disease were enrolled into our study. According to receiver operating characteristic curve analysis, the optimal red blood cell distribution width cut-off value for predicting coronary artery lesions was 14.55% (area under the curve was 0.721; p=0.000); eighty-three patients (19.7%) had coronary artery lesions, and 70% of the patients with coronary artery lesions had red blood cell distribution width level >14.55%. Logistic regression analysis revealed that fever duration >14 days (odds ratio was 3.42, 95% confidence interval was 1.27–9.22; p=0.015), intravenous immunoglobulin resistance (odds ratio was 2.33, 95% confidence interval was 1.02–5.29; p=0.04), and red blood cell distribution width >14.55% (odds ratio was 3.49, 95% confidence interval was 2.01–6.05; p=0.000) were independent predictors of coronary artery lesions in patients with Kawasaki disease. In Conclusion, red blood cell distribution width may be helpful for predicting coronary artery lesions in patients with Kawasaki disease.

Keywords

Kawasaki diseasered blood cell distribution widthcoronary artery lesions
Type
Original Articles
Information
Cardiology in the Young , Volume 26 , Issue 6 , August 2016 , pp. 1151 - 1157
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Copyright
© Cambridge University Press 2015 

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Footnotes

*

Xu H and Fu S contributed equally to this paper.

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