Hostname: page-component-cd9895bd7-gxg78 Total loading time: 0 Render date: 2024-12-29T09:13:06.838Z Has data issue: false hasContentIssue false
  • English
  • Français

Premature ventricular contractions as a side effect of filgrastim in a child with B-thalassaemia

Part of: Electrophysiology

Published online by Cambridge University Press:  29 August 2017

Hanan F. Nazir Open the ORCID record for Hanan F. Nazir [Opens in a new window] ,
Niranjan Joshi  and
Yasser A. Wali
Hanan F. Nazir*
Affiliation:
Child Health Department, SQUH, Muscat, Oman Department of Pediatrics, Faculty of Medicine, Alexandria University, Alexandria, Egypt
Niranjan Joshi
Affiliation:
Child Health Department, SQUH, Muscat, Oman
Yasser A. Wali
Affiliation:
Child Health Department, SQUH, Muscat, Oman Department of Pediatrics, Faculty of Medicine, Alexandria University, Alexandria, Egypt
*
Correspondence to: H. F. Nazir, Child Health Department, SQUH, Alkhoudh, Muscat 123, PO Box 38, Oman. Tel: +968 24 147777; Fax: +968 24147777; E-mail: dr.hanannazir@yahoo.com
Get access Rights & Permissions [Opens in a new window]

Abstract

Premature ventricular contractions are a rare side effect of filgrastim, reported mainly in elderly men. Here we report the case of a 9-year-old child with thalassaemia who developed frequent premature ventricular contractions after three doses of filgrastim were given for deferiprone-induced agranulocytosis. The arrhythmia resolved 3 weeks after discontinuation of filgrastim. Children treated with filgrastim should be carefully monitored for potentially serious arrhythmia.

Keywords

Premature ventricular contractionsfilgrastimB-thalassaemiachildagranulocytosis
Type
Brief Report
Information
Cardiology in the Young , Volume 28 , Issue 1 , January 2018 , pp. 155 - 158
Check for updates
Copyright
© Cambridge University Press 2017 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Pontikoglou, C, Papadaki, HA. Idiosyncratic drug-induced agranulocytosis: the paradigm of deferiprone. Hemoglobin 2010; 34: 291–304.Google Scholar
2. Wali, Y, Al-Shindhani, A, Daar, S. Agranulocytosis in beta thalassemia major patients treated with oral iron chelating agent deferiprone. Oman Med J 2008; 23: 275–277.Google Scholar
3. Tricta, F, Uetrecht, J, Galanello, R, et al. Deferiprone-induced agranulocytosis: 20 years of clinical observations. Am J Hematol 2016; 91: 1026–1031.Google Scholar
4. Kennedy, HL, Whitlock, JA, Sprague, MK, et al. Long-term follow-up of asymptomatic healthy subjects with frequent and complex ventricular ectopy. N Engl J Med 1985; 312: 193–197.CrossRefGoogle ScholarPubMed
5.Keany JE. Premature ventricular contraction. Retrieved January 13, 2017, from Emedicine.medscape.com/article/761148-overview.Google Scholar
6. Beaufort-Krol, GC, Dijkstra, SS, Bink-Boelkens, MT. Natural history of ventricular premature contractions in children with a structurally normal heart: does origin matter? Europace 2008; 10: 998–1003.Google Scholar
7. Sugano, Y, Anzai, T, Yoshikawa, T, et al. Granulocyte colony-stimulating factor attenuates early ventricular expansion after experimental myocardial infarction. Cardiovasc Res 2005; 65: 446–456.Google Scholar
8. Baldo, MP, Davel, AP, Damas-Souza, DM, et al. The antiapoptotic effect of granulocyte colony-stimulating factor reduces infarct size and prevents heart failure development in rats. Cell Physiol Biochem 2011; 28: 33–40.CrossRefGoogle ScholarPubMed
9. Baldo, MP, Rodrigues, SL, Mill, JG. Acute effects of granulocyte colony-stimulating factor on early ventricular arrhythmias after coronary occlusion in rats. J Pharmacol Pharmacother 2012; 3: 39–42.Google Scholar
10. Lee, TM, Chen, CC, Chang, NC. Granulocyte colony-stimulating factor increases sympathetic reinnervation and the arrhythmogenic response to programmed electrical stimulation after myocardial infarction in rats. Am J Physiol Heart Circ Physiol 2009; 297: 512–522.Google Scholar
11. Guneysel, O, Onur, OE, Denizbasi, A. Effects of recombinant human granulocyte colony-stimulating factor (filgrastim) on ECG parameters in neutropenic patients: a single-centre, prospective study. Clin Drug Investig 2009; 29: 551–555.Google Scholar