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Progressively worsening hypertrophic cardiomyopathy in a child with newly diagnosed Costello syndrome while receiving growth hormone therapy

Published online by Cambridge University Press:  22 March 2010

Daisuke Kobayashi ,
Amanda L. Cook  and
Derek A. Williams
Daisuke Kobayashi*
Affiliation:
Division of Pediatric Cardiology, Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America
Amanda L. Cook
Affiliation:
Division of Pediatric Cardiology, Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America
Derek A. Williams
Affiliation:
Division of Pediatric Cardiology, Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America
*
Correspondence to: Dr D. Kobayashi, MD, Division of Pediatric Cardiology, Department of Pediatrics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, United States of America. Tel: +336 716 2694; Fax: +336 716 7100; E-mail: dkobayas@wfubmc.edu
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Abstract

We describe a 6-year-old boy with newly diagnosed Costello syndrome after the diagnosis of severe hypertrophic cardiomyopathy. His neonatal asymmetric septal cardiomyopathy resolved by 9 months of age but reappeared at 6 years of age. This report highlights two important concepts: the association of genetic syndromes with hypertrophic cardiomyopathy and the possibility of worsening severity of hypertrophic cardiomyopathy linked to growth hormone therapy.

Keywords

Genetic syndromesHRAS gene mutationneonatal cardiomyopathy
Type
Brief Reports
Information
Cardiology in the Young , Volume 20 , Issue 4 , August 2010 , pp. 459 - 461
Copyright
Copyright © Cambridge University Press 2010

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