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Quantitative assessment of the association between IL-10 -592 A/C polymorphism and Kawasaki disease risk in Chinese population: evidence from a meta-analysis

Published online by Cambridge University Press:  16 April 2018

Xiaochun Jin ,
Shuzhou Yin ,
Youtao Zhang  and
Xu Chen
Xiaochun Jin
Affiliation:
Department of Anesthesiology, Suzhou Kowloon Hospital, Shanghai Jiao Tong University School of Medicine, Suzhou, People’s Republic of China
Shuzhou Yin
Affiliation:
Department of Anesthesiology, Suzhou Kowloon Hospital, Shanghai Jiao Tong University School of Medicine, Suzhou, People’s Republic of China
Youtao Zhang
Affiliation:
Department of Clinical Laboratory, First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China
Xu Chen*
Affiliation:
Department of Clinical Laboratory, First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China
*
Author for correspondence: X. Chen, Department of Clinical Laboratory, First Affiliated Hospital of Soochow University, 188 Shizi Road, Suzhou 215006, People’s Republic of China. Tel: +86 139 1359 4769; Fax: +86 139 1359 4769; E-mail: 934944882@qq.com
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Abstract

Background

IL-10, as a proinflammatory and anti-inflammatory cytokine, has been thought to have an important role in the development of Kawasaki disease. Variation in the IL-10 gene might lead to altered protein production, which may result in Kawasaki disease. Several studies have been performed to investigate the IL-10 -592 A/C polymorphism and Kawasaki disease risk. Unfortunately, the results of previous studies were inconsistent. Therefore, we performed a meta-analysis to derive a more precise estimation of the association between the IL-10 -592 A/C polymorphism and Kawasaki disease risk.

Method

The association between the IL-10 -592 A/C polymorphism and Kawasaki disease risk was assessed by odds ratios (ORs) together with their 95% confidence intervals (CIs). Six studies were enrolled in the present meta-analysis.

Results

Overall, no significant association between IL-10 -592 A/C polymorphism and Kawasaki disease risk was found under allele contrast (A versus C: OR=0.95, 95% CI=0.77–1.18, p=0.668), homozygote comparison (AA versus CC: OR=0.86, 95% CI=0.56–1.31, p=0.475), heterozygote comparison (CA versus CC: OR=0.88, 95% CI=0.65–1.19, p=0.479), recessive genetic model (AA versus CA/CC: OR=0.96, 95% CI=0.73–1.28, p=0.801), or dominant genetic model (AA/CA versus CC: OR=0.85, 95% CI=0.64–1.13, p=0.275).

Conclusions

We conclude that IL-10 -592 A/C polymorphism was not associated with Kawasaki disease risk in the Chinese population. However, more primary large-scale and well-designed studies are still required to further evaluate the interaction of IL-10 -592 A/C polymorphism with Kawasaki disease risk.

Keywords

Interleukin-10polymorphismKawasaki diseaseinflammationmeta-analysis
Type
Original Articles
Information
Cardiology in the Young , Volume 28 , Issue 6 , June 2018 , pp. 811 - 815
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Copyright
© Cambridge University Press 2018 

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