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Genetics of warfarin-resistance in house mice of three separate localities

Published online by Cambridge University Press:  15 May 2009

Felicity J. MacSwiney  and
Margaret E. Wallace
Felicity J. MacSwiney
Affiliation:
Department of Genetics, University of Cambridge
Margaret E. Wallace
Affiliation:
Department of Genetics, University of Cambridge
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Summary

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Mice from Loughborough and Nottingham were obtained in order to compare the inheritance of warfarin resistance in these populations with that established for a Cambridge population (Wallace & MacSwiney, 1976). Using the same breeding programme and warfarin testing technique, it is established that resistance in the new areas is, as in the Cambridge area, controlled by the major resistance gene, War, in chromosome 7, with penetrance affected by sex and modifiers. In addition, survival differences in males of different ages strongly suggests that War + has less penetrance with age. Penetrance differences between the experiments establishes that wild populations differ in their modifier complex and that more than one modifier, probably several, exist. Questions are posed as to the adaptive significance of the phenomena, and the way in which they work, in the patchwork of warfarin baited and unbaited areas in this country.

Type
Research Article
Information
Journal of Hygiene , Volume 80 , Issue 1 , February 1978 , pp. 69 - 75
Copyright
Copyright © Cambridge University Press 1978

References

REFERENCES

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