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The Mechanism of Self-Disinfection of the Human Skin and its Appendages

Published online by Cambridge University Press:  15 May 2009

J. M. L. Burtenshaw
J. M. L. Burtenshaw
Affiliation:
From the Inoculation Department, St Mary's Hospital, London, and The Bacteriological Laboratory, County Public Health Department, Stafford
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1. Four β-haemolytic strains of Streptococcus, suspended in normal saline, showed progressive increase in mortality, as the pHwas lowered from 7·5 to 5·0; below pH 5·0 the mortality was greatly accentuated.

2. Ether and alcohol extracts of human skin and its appendages were powerfully, saline extracts more weakly and inconstantly, lethal to the haemolytic Streptococcus and to certain other organisms.

3. The long chain fatty acids and soaps are the chief, if not the only, bactericidal constituents of skin and its appendages.

4. Experiments are described illustra ting the streptococcocidal effect of various acids occurring in animal fats.

5. Cystein and blood inhibit the streptoeoccocidal activity of skin fats and certain fatty acids. Ultra-violet light may increase this activity, or abolish, the inhibition exercised by cystein.

6. The mechanism of the sterilizing power of fatty acids and soaps, the influence exerted by cystein, blood, and ultra-violet light on the sterilizing power, of skin fats and fatty acids, and the relationship of skin fatty acids to lysozyme are discussed.

Type
Research Article
Information
Journal of Hygiene , Volume 42 , Issue 2 , April 1942 , pp. 184 - 210
Copyright
Copyright © Cambridge University Press 1942

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