Hostname: page-component-78c5997874-fbnjt Total loading time: 0 Render date: 2024-11-11T07:20:22.526Z Has data issue: false hasContentIssue false
  • English
  • Français

Assessing risk of bias in randomized controlled trials

Published online by Cambridge University Press:  11 April 2011

Marianna Purgato ,
Corrado Barbui  and
Andrea Cipriani
Marianna Purgato
Affiliation:
Department of Public Health and Community Medicine, Section of Psychiatry and Clinical Psychology, University of Verona (Italy)
Corrado Barbui
Affiliation:
Department of Public Health and Community Medicine, Section of Psychiatry and Clinical Psychology, University of Verona (Italy)
Andrea Cipriani*
Affiliation:
Department of Public Health and Community Medicine, Section of Psychiatry and Clinical Psychology, University of Verona (Italy)
*
Address for correspondence: Dr. A. Cipriani, Department of Public Health and Community Medicine, Section of Psychiatry and Clinical Psychology, University of Verona, Piazzale L.A. Scuro 10, 37134 Verona (Italy). Fax: +39–045–8027498 E-mail: andrea.cipriani@univr.it
Get access Rights & Permissions [Opens in a new window]

Abstract

Even though randomised controlled trials are the design of choice for evaluating the efficacy of health care interventions, they are not immune to bias that may affect research process and validity of results. In the present paper we discussed how trial quality may be appraised considering both whether a clinical trial is reported in a comprehensive and complete way (consistently with what had been declared in the study protocol), and whether the characteristics of the trial itself are associated with risk of bias.

Keywords

qualityrandomised controlled trialbiasoutcome reporting
Type
ABC of Methodology
Information
Epidemiology and Psychiatric Sciences , Volume 19 , Issue 4 , December 2010 , pp. 296 - 297
Copyright
Copyright © Cambridge University Press 2010

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Cipriani, A. & Geddes, J.R. (2009). What is a randomised controlled trial? Epidemiologia e Psichiatria Sociale 18, 191–194.CrossRefGoogle ScholarPubMed
Cipriani, A., Purgato, M. & Barbui, C. (2009). Why internal and external validity of experimental studies are relevant for clinical practice? Epidemiologia e Psichiatria Sociale 18, 101–103.CrossRefGoogle ScholarPubMed
Jüni, P., Altman, D.G. & Egger, M. (2001). Systematic reviews in health care: assessing the quality of controlled clinical trials. British Medical Journal 323, 42–46.CrossRefGoogle ScholarPubMed
Moher, D., Jadad, A.R., Nichol, G., Penman, M., Tugwell, P. & Walsh, S. (1995). Assessing the quality of randomized controlled trials: An annotated bibliography of scales and checklists. Controlled Clinical Trials 16, 62–73.CrossRefGoogle ScholarPubMed
Schulz, K.F., Altman, D.G., Moher, D. & Group, Consort (2010). CONSORT 2010 statement: updated guidelines for reporting parallel group randomized trials. British Medical Journal 340, c332.CrossRefGoogle Scholar