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RCTs in psychiatry: challenges and the future

Published online by Cambridge University Press:  11 October 2011

Rebecca Walwyn  and
Simon Wessely
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Abstract

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Type
Editorials
Information
Epidemiology and Psychiatric Sciences , Volume 14 , Issue 3 , September 2005 , pp. 127 - 131
Copyright
Copyright © Cambridge University Press 2005

References

REFERENCES

Burns, T., Creed, F., Fahy, T., Thompson, S., Tyrer, P. & White, I. (1999). Intensive versus standard case management for severe psychotic illness: A randomised trial. Lancet 353 (9171), 2185–2189.CrossRefGoogle ScholarPubMed
Collins, R., Peto, R., Gray, R. & Parish, S. (1996). Large scale randomized evidence: Trials and overviews. In Oxford Textbook of Medicine, 3rd ed. (Ed. Weatherall, D., Ledingham, J. and Warrell, D.). pp. 21–32. Oxford University Press: Oxford.Google Scholar
Crawford, M.J., Weaver, T., Rutter, D., Sensky, T. & Tyrer, P. (2002). Evaluating new treatments in psychiatry: The potential value of combining qualitative and quantitative research methods. International Review of Psychiatry 14(1). 6–11.CrossRefGoogle Scholar
Everitt, B. & Wessely, S. (2003). Clinical Trials in Psychiatry. Oxford University Press: Oxford.CrossRefGoogle Scholar
Geddes, J. (2002). Can we conduct some large simple trials in bipolar disorder? Bipolar Disorder A, Suppl 1. 62–63.CrossRefGoogle ScholarPubMed
Gilbody, S., Wahlbeck, K. & Adams, C. (2002). Randomized controlled trials in schizophrenia: a critical perspective on the literature. Acta Psychiatrica Scandinavica 105(4). 243–251.CrossRefGoogle ScholarPubMed
Horton, R. (2001). The clinical trial: deceitful, disputable, unbelievable, unhelpful, and shameful-what next? (Keynote Address). Society for Clinical Trials Annual Meeting.Google Scholar
Hotopf, M., Lewis, G. & Normand, C. (1997). Putting trials on trial - the costs and consequences of small trials in depression: a systematic review of methodology. Journal of Epidemiology and Community Health 51(4), 354–358.CrossRefGoogle ScholarPubMed
Johnson, T. (1998). Clinical trials in psychiatry: Background and statistical perspective. Statistical Methods in Medical Research 7(3), 209–234.CrossRefGoogle ScholarPubMed
Kroenke, K., West, S.L., Swindle, R., Gilsenan, A., Eckert, G.J., Dolor, R., Stang, P., Zhou, X.-H., Hays, R. & Weinberger, M. (2001). Similar effectiveness of paroxetine, fluoxetine, and sertraline in primary care: A randomized trial. Journal of the American Medical Association 286(23), 2947–2955.CrossRefGoogle ScholarPubMed
McKee, M., Britton, A., Black, N., McPherson, K., Sanderson, C. & Bain, C. (1999). Methods in health services research: Interpreting the evidence: Choosing between randomised and non-randomised studies. British Medical Journal 319(7205), 312–315.CrossRefGoogle ScholarPubMed
MRC (2002). A framework for development and evaluation of RCTs for complex interventions to improve health. Retrieved May 3. 2005 from http://www.mrc.ac.uk/pdf-mrc_cpr.pdfGoogle Scholar
Persons, J.B. & Silberschatz, G. (1998). Are results of randomized controlled trials useful to psychotherapists? Journal of Consulting and Clinical Psychology 66(1), 126–135.CrossRefGoogle ScholarPubMed
Rothwell, P. (1995). Can overall results of clinical trials be applied to all patients? Lancet 345(8965), 1616–1619.CrossRefGoogle ScholarPubMed
Stephenson, J. & Imrie, J. (1998). Why do we need randomised controlled trials to assess behavioural interventions? British Medical Journal 316(7131), 611–613.CrossRefGoogle ScholarPubMed
Swartz, M.S., Swanson, J.W., Hiday, V.A., Wagner, H.R., Burns, B.J. & Borum, R. (2001). A randomized controlled trial of outpatient commitment in North Carolina. Psychiatric Services 52(3), 325–329.CrossRefGoogle ScholarPubMed
Thornley, B. & Adams, C. (1998). Content and quality of 2000 controlled trials in schizophrenia over 50 years. British Medical Journal 317(7167), 1181–1184.CrossRefGoogle ScholarPubMed
Tollefson, G.D., Beasley, CM. Jr, Tran, P.V., Street, J.S., Krueger, J.A., Tamura, R.N., Graffeo, K.A. & Thieme, M.E. (1997). Olanzapine versus haloperidol in the treatment of schizophrenia and schizoaffective and schizophreniform disorders: Results of an international collaborative trial. American Journal of Psychiatry 154(4), 457–465.Google ScholarPubMed