Hostname: page-component-78c5997874-lj6df Total loading time: 0 Render date: 2024-11-10T23:51:35.706Z Has data issue: false hasContentIssue false
  • English
  • Français

Correlaciones Entre Potenciales Evocados Auditivos Estándar y Síntomas en un Grupo de 50 Pacientes Esquizofrénicos

Published online by Cambridge University Press:  12 May 2020

T. Bougerol ,
A. Benraiss  and
J. C. Scotto
T. Bougerol
Affiliation:
Departamento de Psiquiatría Adulta, Hospital Santa Margarita, Marsella, F13294Francia
A. Benraiss
Affiliation:
Departamento de Psiquiatría Adulta, Hospital Santa Margarita, Marsella, F13294Francia
J. C. Scotto
Affiliation:
Departamento de Psiquiatría Adulta, Hospital Santa Margarita, Marsella, F13294Francia
Get access

Resumen

Se registraron los potenciales evocados auditivos (AEPs) estándar en 50 pacientes esquizofrénicos y 47 controles normales. Todos los pacientes recibieron calificaciones en la Escala de Evaluación Psiquiátrica Breve (BPRS), la Escala para la Evaluación de Síntomas Negativos (SANS), la Escala para la Evaluación de Síntomas Positivos (SAPS) y la Escala del Síndrome Positivo y Negativo (PANSS), y fueron clasificados en tres grupos (pacientes de tipo positivo [n = 10], de tipo negativo [n = 23] y de tipo mixto [n = 17]) según los criterios normativos propuestos por Kay. Las latencias medias de los componentes de los AEPs (NI, P2, N2) y las amplitudes medias entre picos (N1P2, P2N2) no correlacionaban con la edad, la duración de la enfermedad, la duración de la hospitalización o la dosis de neurolépticos. La respuesta evocada no difería entre los tres grupos de pacientes (positivos, negativos y mixtos). Había sólo una tendencia (P = 0,075) a una latencia mayor del componente NI en el grupo de tipo negativo y a una más corta en el grupo de tipo positivo que en los de tipo mixto y de control. La latencia del componente N1 correlacionaba significativamente con los síntomas negativos de la esquizofrenia (las puntuaciones de la SANS). Esta correlación estaba relacionada con la gravedad de una dimensión depresiva del trastorno reflejada por el “factor depresivo” de la BPRS o las subescalas de “aplanamiento afectivo” y “abulia-apatía” de la SANS.

Keywords

potencial evocadoesquizofreniadepresión
Type
Artículo original
Information
European Psychiatry (Ed. Española) , Volume 5 , Issue 5 , June 1998 , pp. 309 - 318
Copyright
Copyright © European Psychiatric Association 1998

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

BIBLIOGRAFIA

Adler, GGattaz, WF. Auditory-evoked potentials in schizophrenic patients before and during neuroleptic treatment. Relationship to psychopathological State. Eur Arch Psychiatry Clin Neurosci 1993; 242: 357-61.Google ScholarPubMed
Adler, LEPachtman, EFranks, RDPechevitch, MWaldo, MC. Freedman, R. Neurophysiological evidence for a defect in neural mechanisms involved in sensory gating in schizophrenia. Biol Psychiatry 1982; 17: 639-54.Google Scholar
Andreasen, NCOlsen, S. Negative/positive schizophrenia: definition and validation. Arch Gen Psychiatry 1982; 39: 789-94.Google Scholar
Baribeau-Braun, JPicton, TWGoselin, JY. Schizophrenia: a neurophysiological evaluation of abnormal information processing. Science 1983; 219: 874-6.Google ScholarPubMed
Blackwood, DHRWhalley, LJChristie, JEBlackburn, IMStClair, DM. Mclnnes, A. Changes in auditory P3 event-related potential in schizophrenia and depression. Brit J Psychiatry 1987; 150: 154-60.CrossRefGoogle ScholarPubMed
Braff, DLSaccuzzo, DP. The time course of information-processing deficits in schizophrenia. Am J Psychiatry 1985; 142: 170-4.Google Scholar
Bruder, GTowey, JStewart, DFriedman, HTenke, C. Quitkin, FM. Event-related potentials in depression: influence of tasks, stimulus hemifield and clinical features on P3 latency. Biol Psychiatry 1991; 30: 233-46.CrossRefGoogle ScholarPubMed
Catts, SVShelley, AMWard, PBLiebert, BMcConaghy, NAndrews, S. Michie, PT. Brain potential evidence for an auditory sensory memory deficit in schizophrenia. Am J Psychiatry 1995; 152: 213-19.Google Scholar
Cornblatt, BALenzenweger, MFDoworkin, RH. Positive and negative schizophrenic symptoms, attention and information processing. Schizophr Bull 1985; 11: 397–407.Google ScholarPubMed
Davis, JM. Comparative doses and costs of antipsychotic medications. Arch Gen Psychiatry 1976; 33: 858-61.CrossRefGoogle Scholar
Drouet, AHort-Legrand, CFéline, AMetral, S, Symptomatologie schizophrénique négative et onde P300. Encéphale 1993; XIX: 229-35.Google Scholar
Faux, SFMcCarley, RWNestor, PGShenton, MEPollak, SD. Penhune, V et al. P300 topographic asymmetries are present in unmedicated schizophrenics. Electroencephalogr Clin Neurophysiol 1993; 88: 32–41.CrossRefGoogle ScholarPubMed
Javitt, DCDoneshka, PGrochowski, S. Ritter W. Impaired mismatch negativity generation reflects widespread dysfunction of working memory in schizophrenia. Arch Gen Psychiatry 1995; 52: 550-8.CrossRefGoogle Scholar
Judd, LLMcAdams, LBudnick, B. Braff DL. Sensory gatting deficits in schizophrenia: new results. Am J Psychiatry 1992; 149: 488-93.Google Scholar
Kay, SR. Positive and negative syndromes in schizophrenia. Assessment and research. New York: Brunner/Mazel, 1991.Google Scholar
Kay, SRFiszbein, AOpler, LA. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 1987; 13: 261-76.CrossRefGoogle Scholar
Kerkhof, GA. Event-related potentials and auditory signal detection. Their diurnal variation for moming-type and evening-type subjects. Psychophysiol 1982; 19: 94103.CrossRefGoogle ScholarPubMed
Laurent, AGarcía-Larrea, LDalery, JTerra, JLD’Amato, TMarie-Cardine, MMauguière, F, Etude du potentiel P300 dans la schizophrénie, Encéphale 1993; XIX: 221-7.Google Scholar
Louza, MRMaurer, K. Differences between paranoid and non-paranoid schizophrenic patients on the somatosensory P300 event-related potential. Neuropsychobiol 1989; 21: 59–66.CrossRefGoogle Scholar
Nuechterlein, KHDawson, ME. Neurophysiological and psychophysiological approaches to schizophrenia. In: Bloom, FE and Kupfer, DJ, eds. Psychopharmacology: the fourth generation of progress. New York: Raven Press, 1995: 1235-44.Google Scholar
Overall, JE. The Brief Psychiatric Rating Scale in psychopharmacological research. In: Pichot, P, ed. Psychological measurements in psychopharmacology: modern problems in psychopharmacology vol. 7. Basel: Karger, 1976: 67-8.Google Scholar
Overall, JEGorham, DR. The Brief Psychiatric Rating Scale. Psychol Rep 1962; 10: 799–812.CrossRefGoogle Scholar
Partiot, APierson, A. Le Houezec, JDodin, VRenault, BJouvent, R. Loss of automatic processes and blunted affect in depression: a P3 study. Eur Psychiairy 1993; 8: 309-18.Google Scholar
Pfefferbaum, AWenegrat, BGFord, JMRoth, WT. Koppel, BS. Clinical application of the P3 component of event-related potentials. II: dementia, depression and schizophrenia. Electroencephalogr Clin Neurophysiol 1984; 59: 104-24.CrossRefGoogle Scholar
Picton, TWHillyard, SA. Endogenous event-related potentials. In: Picton, TW, ed. Handbook of Electroencephalography and Clinical Neurophysiology vol. 3. Amsterdam: Elsevier, 1988: 361–426.Google Scholar
Pierson, APartiot, AAmmar, Set, al, ERPs: differences between anxious-impulsive and blunted-affect depressive in-patients. In: Ansseau, MVon Frenckell, RFranck, G, eds. Biological markers of depression : State of the art. Amsterdam: Elsevier, 1991: 121-9.Google Scholar
Roth, WTCannon, EH. Some features of the auditory evoked response in schizophrenics. Arch Gen Psychiatry 1972; 27: 466-71.CrossRefGoogle ScholarPubMed
Saletu, BItil, TMSaletu, M. Auditory evoked response, EEG, and thought process in schizophrenics. Am J Psychiatry 1971; 128: 336-44.CrossRefGoogle ScholarPubMed
Saletu, BSaletu, MSimeon, J. Marasa, J. Fluphenazine treatment in the psychotic child: clinical-evoked potential correlations. Compr Psychiatry 1975; 16: 265-78.CrossRefGoogle ScholarPubMed
Schliegel, SNieber, DHerman, C. Bakauski, E. Latencies of the P300 component of the auditory event related potential in depression are related to the Beck Rafaelsen Melancholia scale but not to the Hamilton Rating Scale for Depression. Acta Psychiatr Scand 1991; 83: 438-40.Google Scholar
Schwarzkopf, SBLamberti, JSJiménez, MKane, CFHendriks, M. Nasrallah, HA. Visual evoked potential correlates of positive/negative symptoms in schizophrenia. Biol Psychiatry 1990; 27: 400-10.CrossRefGoogle Scholar
Shagass, C. Sensory evoked potentials in psychosis. In: Begleiter, H, ed. Evoked brain potentials and behavior. New York: Plenum Press, 1979: 467-98.CrossRefGoogle Scholar
Shagass, CRoemer, RAStraumanis, JJ. Amadeo, M. Evoked potential correlates of psychosis. Biol Psychiatry 1978; 13: 163-84.Google Scholar
Shagass, CStraumanis, JJRoemer, RA. Amadeo, M. Evoked potentials of schizophrenics in several sensory modalities. Biol Psychiatry 1977; 12: 221-35.Google ScholarPubMed
Shenton, MEFaux, SFMcCarley, RWBallinger, RColeman, MTorello, M. Duffy, FH. Correlations between abnormal auditory P300 topography and positive symptoms in schizophrenia: a preliminary report. Biol Psychiatry 1989; 25: 710-16.CrossRefGoogle ScholarPubMed
Strik, WKDierks, TMaurer, K. Amplitudes of auditory P300 in remitted and residual schizophrenics - correlations with clinical features. Neuropsychobiol 1993; 27: 54–60.CrossRefGoogle ScholarPubMed
Sutton, SBraren, MZubin, J. John ER, . Evoked-potential correlates of stimulus uncertainty. Science 1965; 150: 1187-8.CrossRefGoogle ScholarPubMed
Ward, PBCatts, SVFox, AMMichie, PT. McConaghy N, . Auditory selective attention and event-related potentials in schizophrenia. Brit J Psychiatry 1991; 158: 534-9.CrossRefGoogle Scholar
Weiner, RUOpler, LAKay, SRMerriam, AR. Papouchis, N. Visual information processing in positive, mixed and negative schizophrenic syndromes. J Nerv Ment Dis 1990; 178: 616-26.CrossRefGoogle ScholarPubMed