The first Iranian to study medicine abroad was sent to Britain by the Iranian government in 1811, during the early decades of the Qajar period (1796–1925). The second student was sent to France in 1815, along with four other students. Another group of five students, including the third student of medicine, was sent to France in 1845. Forty-two others, including five medical students, were dispatched to France in 1858. Most members of the latter group were among the first graduates of Tehran Dar al-Fonun (House of Techniques) School. Then, in 1928, during Reza Shah Pahlavi's reign (1925–41), a special act was passed by the Iranian parliament (Majlis) according to which the Ministry of Education would send 100 students abroad annually for higher education at the government's expense. The practice was suspended in 1935 with the advent of the Second World War. Between 1928 and 1935, a total of 640 students, including 125 medical students, were sent abroad. The majority of the medical students (84 percent) were sent to France. Most of these medical graduates returned to Iran and in subsequent years played a significant role in further propagation of modern medical knowledge in the country. The paper presents a brief historical account of the conditions of public health and medical education between 1811 and 1935 as well as biographical sketches of some of the best-known or most influential medical figures among these graduates.