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Antimicrobial properties of plant secondary metabolites

Published online by Cambridge University Press:  07 March 2007

R. John Wallace
R. John Wallace*
Affiliation:
Rowett Research Institute, Aberdeen, AB21 9SB, UK
*
Corresponding author: John Wallace, fax +44 1224 716687, email rjw@rri.sari.ac.uk
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Abstract

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Increasing awareness of hazards associated with the use of antibiotic and chemical feed additives has accelerated investigations into plants and their extracts as feed additives. The present review mainly discusses two classes of plant secondary compounds in this context, i.e. essential oils and saponins. The broader potential of plants and their extracts is illustrated by the progress of an EC Framework 5 project, ‘Rumen-up’. Dietary inclusion of a commercial blend of essential oils causes markedly decreased NH3 production from amino acids in rumen fluid taken from sheep and cattle. This effect is mediated partly by the effects on hyper-NH3-producing bacteria and the protein- and starch-fermenting rumen bacterium, Ruminobacter amylophilus. Saponin-containing plants and their extracts suppress the bacteriolytic activity of rumen ciliate protozoa and thereby enhance total microbial protein flow from the rumen. The effects of some saponins are transient, because saponins are hydrolysed by bacteria to their corresponding sapogenin aglycones, which are much less toxic to protozoa. Saponins also have selective antibacterial effects that may prove useful in, for example, controlling starch digestion. The ‘Rumen-up’ project began with a targetted collection of European plants and their extracts, which partners have tested for their effects on rumen proteolysis, protozoa, methanogenesis and lactate production. A success rate of about 5% in terms of positive hits illustrates that plant secondary compounds, of which essential oils and saponins comprise a small proportion, have great potential as ‘natural’ manipulators of rumen fermentation to benefit the farmer and the environment in the future.

Keywords

Essential oilsManipulationRuminantsSaponins
Type
Symposium on ‘Plants as animal foods: a case of catch 22?’
Information
Proceedings of the Nutrition Society , Volume 63 , Issue 4 , November 2004 , pp. 621 - 629
Copyright
Copyright © The Nutrition Society 2004

References

Attwood, GT, Klieve, AV, Ouwerkerk, D, Patel, BKC (1998) Ammonia-hyperproducing bacteria from New Zealand ruminants Applied and Environmental Microbiology 64 1796–1804CrossRefGoogle ScholarPubMed
Bird, SH, Hill, MK, Leng, RA (1979) The effect of defaunation of the rumen on the growth of lambs on low-protein high-energy diets British Journal of Nutrition 42 81–87CrossRefGoogle ScholarPubMed
Bird, SH, Leng, RA (1978) The effect of defaunation of the rumen on the growth of cattle on low-protein high-energy diets British Journal of Nutrition 40 163–167CrossRefGoogle ScholarPubMed
Broudiscou, L, Sylvie, P, Poncet, C (1994) Effect of linseed oil supplementation on feed degradation and microbial synthesis in the rumen of ciliate free and refaunated sheep Animal Feed Science and Technology 49 189–202CrossRefGoogle Scholar
Chang, ST, Chen, PF, Chang, SC (2001) Antibacterial activity of leaf essential oils and their constituents from Cinnamomum osmophloeum Journal of Ethnopharmacology 77 123–127CrossRefGoogle ScholarPubMed
Cheeke, PR (1996) Biological effects of feed and forage saponins and their impacts on animal production Saponins Used in Food and Agriculture 377 – 385 Waller GR Yamasaki K New York Plenum PressCrossRefGoogle Scholar
Chesson, A (2004) Plant secondary metabolites in practical animal nutrition Proceedings of the Nutrition Society 64.Google Scholar
Demeyer, D, Van, Nevel C (1986) Influence of substrate and microbial interaction on efficiency of rumen microbial growth Reproduction Nutrition Developpement 26 161–179CrossRefGoogle ScholarPubMed
Diaz, A, Avendan, OM, Escobar, A (1994) Evaluation of Sapindus saponaria as a defaunating agent and its effects on different ruminal digestion parameters Livestock Research and Rural Development 5 1–10Google Scholar
Eadie, JM, Shand, WJ (1981) The effect of synperonic NP9 upon ciliate free and faunated sheep Proceedings of the Nutrition Society 40 113AGoogle Scholar
Elgayyar, M, Draughon, FA, Golden, DA, Mount, JR (2001) Antimicrobial activity of essential oils from plants against selected pathogenic and saprophytic microorganisms Journal of Food Protection 64 1019–1024CrossRefGoogle ScholarPubMed
Eugène, M, Archimède, H, Sauvant, D (2004) Quantitative meta-analysis on the effects of defaunation of the rumen on growth, intake and digestion in ruminants Livestock Production Science 85 81–97CrossRefGoogle Scholar
Finlay, BJ, Esteban, G, Clarke, KJ, Williams, AG, Embley, TM, Hirt, RP (1994) Some rumen ciliates have endosymbiotic symbionts FEMS Microbiology Letters 117 157–162CrossRefGoogle Scholar
Floret, F, Chaudhary, LC, Ellis, WC, El, Hassan, S, McKain, N, Newbold, CJ, Wallace RJ (1999) Influence of 1-[(E)-2-(2-methyl-4-nitrophenyl)diaz-1-enyl]pyrrolidine-2-carboxylic acid and diphenyliodonium chloride on ruminal protein metabolism and ruminal microorganisms Applied and Environmental Microbiology 65 3258–3260CrossRefGoogle ScholarPubMed
Goetsch, AL, Owens, FN (1985) Effects of sarsaponin on digestion and passage rates in cattle fed medium to low concentrates Journal of Dairy Science 68 2377–2384CrossRefGoogle Scholar
Headon, DR, Buggle, K, Nelson, A, Killeen, G (1991) Glycofractions of the Yucca plant and their role in ammonia control Biotechnology in the Feed Industry 95 – 108 Lyons TP Nicholasville, KY Alltech Technical PublicationsGoogle Scholar
Hostettmann, K, Marston, A (1995) Saponins Cambridge Cambridge University PressCrossRefGoogle Scholar
Hristov, AN, McAllister, AT, Van, Herk, FH, Cheng K-J (1999) Effect of Yucca schidigera on ruminal fermentation and nutrient digestion in heifers Journal of Animal Science 77 2554–2563CrossRefGoogle ScholarPubMed
Imai, H, Osawa, K, Yasuda, H, Hamashima, H, Arai, T, Sasatsu, M (2001) Inhibition by the essential oils of peppermint and spearmint of the growth of pathogenic bacteria Microbios 106 31–39 Suppl. 1Google ScholarPubMed
Kayouli, C, Demeyer, DI, Van, Nevel, CJ, Dendooven R (1984) Effect of defaunation on straw digestion in sacco and on particle retention in the rumen Animal Feed Science and Technology 10 165–172Google Scholar
Leng, RA, Bird, SH, Klieve, A, Choo, BS, Ball, FM, Asefa, P, Mudgal, VD, Chaudhry, UB, Haryono, SU &, Hendratno, N (1992) The potential for forage supplements to manipulate rumen protozoa to enhance protein to energy ratio in ruminants fed on poor quality forages. Legume Trees and Other Fodder Trees as Protein Sources for Livestock. FAO Animal Production and Health Paper no. 102, pp. 177–191. Rome: FAO.Google Scholar
Lockwood, BC, Coombs, GH, Williams, AG (1988) Proteinase activity in rumen ciliate protozoa Journal of General Microbiology 134 2605–2614Google ScholarPubMed
Lovelock, LKA, Buchanan-Smith, JG, Forsberg, CW (1982) Difficulties in defaunation of the ovine rumen Canadian Journal of Animal Science 62 299–303CrossRefGoogle Scholar
Lu, CD, Jorgensen, NA (1987) Alfalfa saponins affect site and extent of nutrient digestion in ruminants Journal of Nutrition 117 919–927CrossRefGoogle ScholarPubMed
Lu, CD, Tsai, LS, Schaefer, DM, Jorgensen, NA (1987) Alteration of fermentation in continuous culture of mixed rumen bacteria Journal of Dairy Science 70 799–805CrossRefGoogle ScholarPubMed
McEwan, NR, Graham, RC, Wallace, RJ, Losa, R, Williams, P, Newbold, CJ (2002 a) Effect of essential oils on ammonia production by rumen microbes Reproduction Nutrition Developpement 42 S65 Suppl. 1Google Scholar
McEwan, NR, Graham, RC, Wallace, RJ, Losa, R, Williams, P, Newbold, CJ (2002 b) Effect of essential oils on protein digestion in the rumen Reproduction Nutrition Developpement 42 S65–S66 Suppl. 1Google Scholar
McIntosh, FM, Newbold, CJ, Losa, R, Williams, P, Wallace, RJ (2000) Effects of essential oils on rumen fermentation Reproduction Nutrition Developpement 40 221–222Google Scholar
McIntosh, FM, Williams, P, Losa, R, Wallace, RJ, Beever, DE Newbold CJ (2003) Effects of essential oils on ruminal microorganisms and their protein metabolism Applied and Environmental Microbiology 69 5011–5014CrossRefGoogle ScholarPubMed
McSweeney, CS, Palmer, B, Bunch, R, Krause, DO (1999) Isolation and characterization of proteolytic ruminal bacteria from sheep and goats fed the tannin-containing shrub legume Calliandra calothyrsus Applied and Environmental Microbiology 65 3075–3083CrossRefGoogle ScholarPubMed
Machmuller, A, Osowski, DA, Wanner, M, Kreuzer, M (1998) Potential of various fatty feeds to reduce methane release from rumen fermentation in vitro (Rusitec) Animal Feed Science and Technology 71 117–130CrossRefGoogle Scholar
Makkar, HP, Becker, K (1997) Degradation of Quillaja saponins by mixed culture of rumen microbes Letters in Applied Microbiology 25 243–245CrossRefGoogle ScholarPubMed
Makkar, HPS, Sen, S, Blummel, M, Becker, K (1998) Effects of fractions containing saponins from Yucca schidigera, Quillaja saponaria and Acacia auriculoformis on rumen fermentation Journal of Agricultural and Food Chemistry 46 4324–4328CrossRefGoogle Scholar
Marino, M, Bersani, C, Comi, G (2001) Impedance measurements to study the antimicrobial activity of essential oils from Lamiaceae and Compositae International Journal of Food Microbiology 67 187–195Google Scholar
Matsumoto, M, Kobayashi, T, Takenaka, A, Itabashi, H (1991) Defaunation effects of medium-chain fatty acids and their derivatives on goat rumen protozoa Journal of General Microbiology 37 439–445CrossRefGoogle Scholar
Mehrez, AZ, Ørskov, ER (1977) A study of the artificial fibre bag technique for determining the digestibility of feeds in the rumen Journal of Agricultural Science, Cambridge 88 645–650CrossRefGoogle Scholar
Nagy, JG, Tengerdy, RP (1968) Antibacterial action of essential oils of Artemisia as an ecological factor. II. Antibacterial action of the volatile oils of Artemisia tridentata (big sagebrush) on bacteria from the rumen of mule deer Applied Microbiology 16 441–444Google ScholarPubMed
Navas-Camacho, A, Laredo, MA, Cuesta, A, Anzola, H, Leon, JC (1993) Effect of supplementation with a tree legume forage on rumen function Livestock Research and Rural Development 5 58–71Google Scholar
Newbold, CJ, Chamberlain, DG (1988) Lipids as rumen defaunating agents Proceedings of the Nutrition Society 47 154AGoogle Scholar
Newbold, CJ, El, Hassan, SM, Wang, J, Ortega, ME, Wallace RJ (1997) Influence of foliage from African multipurpose trees on activity of rumen protozoa and bacteria British Journal of Nutrition 78 237–249CrossRefGoogle ScholarPubMed
Newbold, CJ, McIntosh, FM, Williams, P, Losa, R, Wallace, RJ (2004) Effects of a specific blend of essential oils on rumen fermentation Animal Feed Science and Technology 114 105–112CrossRefGoogle Scholar
Odenyo, A, Osuji, PO, Karanfil, O (1997) Effect of multipurpose tree (MPT) supplements on ruminal ciliate protozoa Animal Feed Science and Technology 67 169–180CrossRefGoogle Scholar
Oh, HK, Jones, MB, Longhurst, WM (1968) Comparison of rumen microbial inhibition resulting from various essential oils isolated from relatively unpalatable plant species Applied Microbiology 16 39–44CrossRefGoogle ScholarPubMed
Oh, HK, Sakai, T, Jones, MB, Longhurst, WM (1967) Effect of various essential oils isolated from Douglas fir needles upon sheep and deer rumen microbial activity Applied Microbiology 15 777–784CrossRefGoogle ScholarPubMed
Orpin, CG (1977) Studies on the defaunation of the ovine rumen using dioctyl sodium sulfosuccinate Journal of Applied Bacteriology 43 309–318CrossRefGoogle Scholar
Orpin, CG, Joblin, KN (1997) The rumen anaerobic fungi The Rumen Microbial Ecosystem 140 – 195 Hobson PN Stewart CS London Chapman & HallGoogle Scholar
Rossi, J (1995) Additives for animal nutrition and technique for their preparation. European Patent EP 0646321 B1.Google Scholar
Russell, JB, Onodera, R, Hino, T (1991) Ruminal protein fermentation: new perspectives on previous contradictions Physiological Aspects of Digestion and Metabolism in Ruminants 681 – 697 Tsuda T Sasaki Y Kawashima R San Diego, CA Academic PressCrossRefGoogle Scholar
Shapiro, S, Meier, A, Guggenheim, B (1994) The antimicrobial activity of essential oils and essential oil components towards oral bacteria Oral Microbiology and Immunology 9 202–208CrossRefGoogle ScholarPubMed
Stewart, CS, Flint, HJ, Bryant, MP (1997) The rumen bacteria The Rumen Microbial Ecosystem 10 – 72 Hobson PN Stewart CS London Chapman & HallCrossRefGoogle Scholar
Teferedegne, B (2000)Google Scholar
Teferedegne, B, Osuji, PO, Odenyo, AA, Wallace, RJ, Newbold, CJ (1999) Influence of foliage of different accessions of the sub-tropical leguminous tree, Sesbania sesban, on ruminal protozoa in Ethiopian and Scottish sheep Animal Feed Science and Technology 78 11–20CrossRefGoogle Scholar
Ushida, K, Jouany, J-P, Demeyer, DI (1991) Effects of presence or absence of rumen protozoa on the efficiency of utilization of concentrate and fibrous feeds Physiological Aspects of Digestion and Metabolism in Ruminants 625 – 654 Tsuda T Sasaki Y Kawashima R San Diego, CA Academic Press IncCrossRefGoogle Scholar
Valdez, FR, Bush, LJ, Goetsch, AL, Owens, FN (1986) Effect of steroidal sapogenins on ruminal fermentation and on production of lactating dairy cows Journal of Dairy Science 69 1568–1575CrossRefGoogle ScholarPubMed
Van, Nevel, CJ, Demeyer DI (1990) Effects of antibiotics, a deaminase inhibitor and sarsaponin on nitrogen metabolism of rumen contents in vitro Animal Feed Science and Technology 31 323–348Google Scholar
Van, Nevel, CJ, Demeyer DI (1996) Control of rumen methanogenesis Environmental Monitoring and Assessment 42 73–97Google Scholar
Wallace, RJ, Arthaud, L, Newbold, CJ (1994) Influence of Yucca shidigera extract on ruminal ammonia concentrations and ruminal microorganisms Applied and Environmental Microbiology 60 1762–1767CrossRefGoogle ScholarPubMed
Wallace, RJ, McEwan, NR, McIntosh, FM, Teferedegne, B, Newbold, CJ (2002) Natural products as manipulators of rumen fermentation Asian-Australasian Journal of Animal Science 15 1458–1468CrossRefGoogle Scholar
Wallace, RJ, McPherson, CA (1987) Factors affecting the rate of breakdown of bacterial protein in rumen fluid British Journal of Nutrition 58 313–323CrossRefGoogle ScholarPubMed
Wallace, RJ, Onodera, R, Cotta, MA (1997) Metabolism of nitrogen-containing compounds The Rumen Microbial Ecosystem 283 – 328 Hobson PN Stewart CS London Chapman & HallCrossRefGoogle Scholar
Wang, Y, McAllister, TA, Newbold, CJ, Rode, LM, Cheeke, PR, Cheng, K-J (1998) Effects of Yucca schidigera extract on fermentation and degradation of steroidal saponins in the rumen simulation technique (RUSITEC) Animal Feed Science and Technology 74 143–153CrossRefGoogle Scholar
Wang, Y, McAllister, TA, Yanke, LJ, Cheeke, PR (2000) Effect of steroidal saponin from Yucca schidigera extract on ruminal microbes Journal of Applied Microbiology 88 887–896CrossRefGoogle ScholarPubMed
Williams, AG, Coleman, GS (1992) The Rumen Protozoa New York Springer Verlag New York IncCrossRefGoogle Scholar
Williams, AG, Coleman, GS (1997) The rumen protozoa The Rumen Microbial Ecosystem 73 – 120 Hobson PN Stewart CS London Chapman & HallCrossRefGoogle Scholar