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Early immunological development and mortality from infectious disease in later life

Published online by Cambridge University Press:  07 March 2007

Sophie E. Moore ,
Andrew C. Collinson ,
Pa Tamba N'Gom ,
Richard Aspinall  and
Andrew M. Prentice
Sophie E. Moore*
Affiliation:
MRC International Nutrition Group, Nutrition and Public Health Interventions Research Unit, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK MRC Keneba, MRC Laboratories, The Gambia, West Africa
Andrew C. Collinson
Affiliation:
MRC Keneba, MRC Laboratories, The Gambia, West Africa Directorate of Child and Women's Health, Royal Devon and Exeter Hospital (Wonford), Exeter, EX2 5DW, UK
Pa Tamba N'Gom
Affiliation:
MRC Keneba, MRC Laboratories, The Gambia, West Africa Department of Immunology, Imperial College London, Chelsea and Westminster Hospital, London, SW10 9NH, UK
Richard Aspinall
Affiliation:
Department of Immunology, Imperial College London, Chelsea and Westminster Hospital, London, SW10 9NH, UK
Andrew M. Prentice
Affiliation:
MRC International Nutrition Group, Nutrition and Public Health Interventions Research Unit, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK MRC Keneba, MRC Laboratories, The Gambia, West Africa
*
Corresponding author: Dr Sophie E. Moore, fax: +44 207 958 8111, email Sophie.Moore@lshtm.ac.uk
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Abstract

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In rural Gambia the risk of mainly infection-related mortality is 10-fold higher for adults born in the nutritionally-debilitating ‘hungry’ season, suggesting that immune function may be compromised by events early in life. The current programme of research focuses on the biological mechanisms underlying this hypothesis, exploring early-life environmental influences on immune development and the long-term functional consequences these influences may have. Results obtained to date show that thymus development during infancy is critically sensitive to environmental exposures, with smaller thymuses observed in the hungry season. Measurement of the frequency of T-cell receptor excision circles indicate that thymus function is also sensitive to seasonal influences, with further studies implicating variations in breast-milk IL-7 as a possible mediator of these effects. Studies in adults have shown that size at birth is positively correlated with antibody responses to vaccination with polysaccharide antigens, thus providing evidence for long-term functional deficits. The present paper will review progress made to date within this field of research.

Keywords

GambiaImmune functionProgrammingThymusVaccine response
Type
Symposium on ‘Nutritional influences on developmental immunology’
Information
Proceedings of the Nutrition Society , Volume 65 , Issue 3 , August 2006 , pp. 311 - 318
Copyright
Copyright © The Nutrition Society 2006

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