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Exercise-induced mitogen-activated protein kinase signalling in skeletal muscle

Published online by Cambridge University Press:  05 March 2007

Yun Chau Long ,
Ulrika Widegren  and
Juleen R. Zierath
Yun Chau Long
Affiliation:
Department of Surgical Sciences, Section for Integrative Physiology, Karolinska Institutet, von Eulers väg 4, II, SE-171 77, Stockholm, Sweden
Ulrika Widegren
Affiliation:
Department of Surgical Sciences, Section for Integrative Physiology, Karolinska Institutet, von Eulers väg 4, II, SE-171 77, Stockholm, Sweden
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Abstract

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Exercise training improves glucose homeostasis through enhanced insulin sensitivity in skeletal muscle. Muscle contraction through physical exercise is a physiological stimulus that elicits multiple biochemical and biophysical responses and therefore requires an appropriate control network. Mitogen-activated protein kinase (MAPK) signalling pathways constitute a network of phosphorylation cascades that link cellular stress to changes in transcriptional activity. MAPK cascades are divided into four major subfamilies, including extracellular signal-regulated kinases 1 and 2, p38 MAPK, c-Jun NH2-terminal kinase and extracellular signal-regulated kinase 5. The present review will present the current understanding of parallel MAPK signalling in human skeletal muscle in response to exercise and muscle contraction, with an emphasis on identifying potential signalling mechanisms responsible for changes in gene expression.

Keywords

Mitogen-activated protein kinaseSkeletal muscleExercise
Type
Symposium 1: Exercise signalling pathways controlling fuel oxidation during and after exercise
Information
Proceedings of the Nutrition Society , Volume 63 , Issue 2 , May 2004 , pp. 227 - 232
Copyright
Copyright © The Nutrition Society 2004

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