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Localization of leptin receptor splice variants in mouse peripheral tissues by immunohistochemistry

Published online by Cambridge University Press:  28 February 2007

R. De Matteis
Affiliation:
Institute of Normal Human Morphology-Anatomy, University of Ancona, Ancona, Italy
K. Dashtipour
Affiliation:
Institute of Normal Human Morphology-Anatomy, University of Ancona, Ancona, Italy
A. Ognibene
Affiliation:
Laboratoiy of Cellular Biology and Electron Microscopy, IOR, Bologna, Italy
S. Cinti*
Affiliation:
Institute of Normal Human Morphology-Anatomy, University of Ancona, Ancona, Italy
*
*Corresponding author: Professor S. Cinti, fax +39 71 220 60 87, email cinti@popcsi.unian.it
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Abstract

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Type
Simposium on ‘Leptin: energy regulation and beyond’
Copyright
Copyright © The Nutrition Society 1998

References

Ahima, RS, Prabakaran, D, Mantzoros, C, Qu, D, Lowell, B, Maratos-Flier, E & Flier, JS (1996) Role of leptin in the neuroendocrine response to fasting. Nature 382, 250252.CrossRefGoogle ScholarPubMed
Berti, L, Kellerer, M, Capp, E & Haring, HU (1997) Leptin stimulates glucose transport and glycogen synthesis in C2C12 myotubes: evidence for a P13-kinase mediated effect. Diabetologia 40, 606609.CrossRefGoogle ScholarPubMed
Blandau, RJ (1977) The female reproductive system. In Histology, pp. 900902 [Weise, L and Greep, RO, editors]. New York: McGraw-Hill.Google Scholar
Campfield, LA, Smith, FJ, Kochan, JP & Burn, P (1997) Central nervous system mediation of the biologic activity of obese protein (leptin): Potential role in states of altered energy balance. In Leptin – the Voice of Adipose Tissue, pp. 118125 [Blum, WF, Kiess, W and Rascher, W, editors]. Leipzig, Germany: J. A. Barth Verlag.Google Scholar
Cao, GW, Considine, RV & Lynn, RB (1997) Leptin receptor in the adrenal medulla of the rat. American Journal of Physiology 273, E448E452.Google Scholar
Chehab, FF, Lim, ME & Lu, R (1996) Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nature Genetics 12, 318320.Google Scholar
Cinti, S, Fredrich, RC, Zingaretti, MC, De matteis, R, Flier, JS & Lowell, BB (1997) Immunohistochemical localisation of leptin and uncoupling protein in white and brown adipose tissue. Endocrinology 138, 797804.CrossRefGoogle ScholarPubMed
Cioffi, JA, Shafer, AW, Zupancic, TJ, Smith-Gbur, J, Mikhail, A, Platika, D & Snodgrass, HR (1996) Novel B219/OB receptor isoforms: Possible role of leptin in hematopoiesis and reproduction. Nature Medicine 2, 585589.CrossRefGoogle ScholarPubMed
Cioffi, JA, Van blerkom, J, Antczak, M, Shafer, A, Wittmer, S & Snodgrass, HR (1997) The expression of leptin and its receptors in pre-ovulatory human follicles. Molecular Human Reproduction 3, 467472.CrossRefGoogle ScholarPubMed
Emilsson, V, Liu, YL, Cawthorne, MA, Morton, NM & Davenport, M (1997) Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion. Diabetes 46, 313316.CrossRefGoogle ScholarPubMed
Fei, H, Okano, HJ, Li, C, Lee, GH, Zhao, C, Darnell, R & Friedman, JM (1997) Anatomic localisation of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. Proceedings of the National Academy of Sciences, USA 94, 70017005.CrossRefGoogle ScholarPubMed
Friedman, JM (1997) Role of leptin and its receptors in the control of body weight. In Leptin – the Voice of Adipose Tissue, pp. 322 [Blum, WF, Kiess, W and Rascher, W, editors]. Leipzig, Germany: J. A. Barth Verlag.Google Scholar
Fruhbeck, G, Aguado, M & Martinez, JA (1997) In vitro lipolytic effect of leptin on mouse adipocytes: evidence for a possible autocrine/paracrine role of leptin. Biochemical and Biophysical Research Communications 240, 590594.CrossRefGoogle ScholarPubMed
Ghilardi, N, Ziegler, S, Wiestner, A, Stoffel, R & Heim, MH (1996) Defective STAT signaling by the leptin receptor in diabetic mice. Proceedings of the Nutional Academy of Sciences, USA 93, 62316235.Google Scholar
Hebel, R & Stromberg, MW (1986) Circulatory system. In Anatomy and Embryology of the Laboratory Rat, p. 113 [Hebel, R and Stromberg, MW, editors]. Wörthsee, Germany: BioMed Verlag.Google Scholar
Hoggard, N, Mercer, JG, Rayner, DV, Moar, K, Trayhum, P & Williams, LM (1997) Localisation of leptin receptor mRNA splice variants in murine peripheral tissues by RT-PCR and in situ hybridisation. Biochemical and Biophysical Research Communications 232, 383387.Google Scholar
Karlsson, C, Lindell, K, Svensson, E, Bergh, C, Lind, P, Billing, H, Carlsson, LM & Carlsson, B (1997) Expression of functional leptin receptors in the human ovary. Journal of Clinical Endocrinology and Metabolism 82, 41444148.Google Scholar
Kellerer, M, Koch, M, Metzinger, E, Mushack, J, Capp, E & Haring, HU (1997) Leptin activates PI-3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways. Diabetologia 40, 13581362.Google Scholar
Kieffer, TJ, Heller, RS & Habener, JF (1996) Leptin receptors expressed on pancreatic β-cells. Biochemical and Biophysical Research Communications 224, 522527.CrossRefGoogle ScholarPubMed
Kutoh, E, Boss, O, Levasseur, F & Giacobino, JP (1998) Quantification of the full length leptin receptor (OB-R) in human brown and white adipose tissue. Life Science 62, 445451.Google Scholar
Leclercq-meyer, V, Considine, RV, Sener, A & Malaisse, WJ (1996) Do leptin receptors play a functional role in the endocrine pancreas? Biochemical and Biophysical Research Communications 229, 794798.Google Scholar
Lee, GH, Proenca, R, Montez, JM, Carroll, KM, Darvishzadeh, JG, Lee, JI & Friedman, JM (1996) Abnormal splicing of the leptin receptor in diabetic mice. Nature 379, 632635.CrossRefGoogle ScholarPubMed
Levin, N, Nelson, C, Gurney, A, Vandlen, R & Sauvage, F (1996) Decreased food intake does not completely account for adiposity reduction after ob protein infusion. Proceedings of the National Academy of science, USA 93, 17261730.Google Scholar
Liu, YL, Emilsson, V & Cawthorne, MA (1997) Leptin inhibits glycogen synthesis in the isolated soleus muscle of obese (ob/ob) mice. FEBS Letters 411, 351355.Google Scholar
Lollmann, B, Griininger, S, Stricker-Krongrad, A & Chiesi, M (1997) Detection and quantification of the leptin receptor splice variants Ob-Ra, b, and e in different mouse tissues. Biochemical and Biophysical Research Communications 238, 648652.Google Scholar
Ludatscher, RM (1968) Fine structure of the muscular wall of rat pulmonary veins. Journal of Anatomy 103, 345357.Google ScholarPubMed
Mounzih, K, Lu, R & Chehab, FF (1997) Leptin treatment rescues the sterility of genetically obese ob/ob males. Endocrinology 138, 11901193.CrossRefGoogle ScholarPubMed
Muoio, DM, Lynis Dohn, G, Fiedorek, FT, Tapscott, EB & Coleman, RA (1997) Leptin directly alters lipid partitioning in skeletal muscle. Diabetes 46, 13601363.Google Scholar
Siegrist-Kaiser, CA, Pauli, V, Juge-Aubry, CE, Boss, O, Pernin, A, Chin, WW, Cusin, I, Rohner-Jeanrenaud, F, Burger, AG, Zapt, J & Meier, CA (1997) Direct effects of leptin on brown and white adipose tissue. Journal of Clinical lnvestigation 100, 28582864.Google Scholar
Tanizawa, Y, Okuya, S, Ishihara, H, Asano, T, Yada, T & Oka, Y (1997) Direct stimulation of basal insulin secretion by physiological concentration of leptin in pancreatic β cells. Endocrinology 138, 45134516.CrossRefGoogle ScholarPubMed
Tartaglia, LA, Dembski, M, Weng, X, Deng, N, Culpepper, J, Devos, R, Richards, GJ, Campfield, LA, Clark, FT, Deeds, J, Muir, C, Sanker, S, Moriarty, A, Moor, KJ, Smutko, JS, Mays, GG, Woolf, EA, Monroe, CA & Tepper, RI (1995) Identification and expression cloning of a leptin receptor, OB-R. Cell 83, 12631271.Google Scholar
Towbin, H, Staehelin, T & Gordon, J (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proceedings of the National Academy of Sciences, USA 76, 43504354.Google Scholar
Wang, MY, Zhou, YT, Newgard, CB & Unger, RH (1996) A novel leptin isoform in rat. FEBS Letters 392, 8790.Google Scholar
Zachow, RJ & Magoffin, DA (1997) Direct intraovarian effects of leptin: Impairment of the synergistic action of insulin-like growth factor-I on follicle-stimulating hormone-dependent estradiol-17 β production by rat ovarian granulosa cells. Endocrinology 138, 847850.Google Scholar