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Marine oils: metabolic effects and role in human nutrition

Published online by Cambridge University Press:  28 February 2007

T. A. B. Sanders
T. A. B. Sanders
Affiliation:
Department of Nutrition and Dietetics, King's College London, University of London, Campden Hill Road, London W8 7AH
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Abstract

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Type
Symposium on ‘Fish and Nutrition’
Information
Proceedings of the Nutrition Society , Volume 52 , Issue 3 , October 1993 , pp. 457 - 472
Copyright
Copyright © The Nutrition Society 1993

References

REFERENCES

Abbey, M., Clifton, P., Belling, B. & Nestel, P. J. (1990). Effect of fish oil on lipoproteins, lecithin: cholesterol acyltransferase, and lipid transfer protein activity in humans. Arteriosclerosis 10, 85–94.CrossRefGoogle ScholarPubMed
Anti, M., Marra, G., Armelao, F., Bartoli, G. M., Ficarelli, R., Percesepe, A., de Vitis, I., Maria, G., Sofo, L., Rapaccini, G. L., Gentiloni, N., Piccioni, E. & Miggiano, G. (1992). Effect of omega-3 fatty acids on rectal mucosal cell proliferation in subjects at risk for colon cancer. Gastroenterology 103, 883–891.CrossRefGoogle ScholarPubMed
Bates, D., Cartlidge, N. E. F., French, J. M., Jackson, M. J., Nightingale, S., Shaw, D. A., Smith, S., Woo, E., Hawkins, S. A., Millar, J. H. D., Belin, J., Conroy, D. M., Gill, S. K., Sidey, M., Smith, A. D., Thompson, R. H. S., Zilkha, K., Gale, M. & Sinclair, H. M. (1989). A double-blind controlled trial of long chain n−3 polyunsaturated fatty acids in the treatment of multiple sclerosis. Journal of Neurology, Neurosurgery & Psychiatry 52, 18–22.CrossRefGoogle ScholarPubMed
Belch, J. J. F., Ansell, D., Madhok, R., O'Dowd, A. & Sturrock, R. D. (1988). Effects of altering dietary fatty acids on requirements for non-steroidal anti-inflammatory drugs in patients with rheumatoid arthritis: a double-blind placebo controlled study. Annals of Rheumatic Diseases 47, 96–104.CrossRefGoogle ScholarPubMed
Bittiner, S. B., Tucker, W. F. G., Cartwright, I. & Bleehen, S. S. (1988). A double-blind, randomised, placebo-controlled trial of fish oil in psoriasis. Lancer i, 378–380.CrossRefGoogle Scholar
Bjister, G. M. & Vles, R. O. (1984). Physiological effect of various mixtures of oleic, linoleic and linolenic acids on growing pigs. 6. Histomorphic investigation of heart, liver, kidney and adipose tissue. Fette, Seifen, Anstrichmittel 86, 93–98.Google Scholar
Bjorneboe, A., Smith, A. K., Bjorneboe, G. A., Thune, P. O. & Drevon, C. A. (1988). Effect of dietary supplementation with n−3 fatty acids on the clinical manifestations of psoriasis. British Journal of Dermatology 118, 77–83.CrossRefGoogle ScholarPubMed
Bønaa, K. H., Bjerve, K. S., Straume, B., Gram, I. T. & Thelle, D. (1990). Effect of eicosapentaenoic and docosahexaenoic acids on blood pressure in hypertension. A population-based intervention trial from the Tromsø study. New England Journal of Medicine 322, 795–801.CrossRefGoogle ScholarPubMed
Borgeson, C. E., Pardini, L. & Reitz, R. C. (1989). Effects of dietary fish oil on human mammary carcinoma and on lipid-metabolizing enzymes. Lipids 24, 290–295.CrossRefGoogle ScholarPubMed
British Nutrition Foundation (1992). British Nutrition Foundation Task Force on Unsaturated Fatty Acids Nutritional and Physiological SigniFcance. London: Chapman & Hall.Google Scholar
Brown, A. J. & Roberts, D. C. K. (1991). Moderate fish oil intake improves lipemic response to a standard meal. A study in 25 healthy men. Arteriosclerosis and Thrombosis 11, 457–466.CrossRefGoogle Scholar
Bruckner, G., Webb, P., Greenwell, L., Chow, C. & Richardson, D. (1987). Fish oil increases peripheral capillary blood cell velocity in humans. Atherosclerosis 66, 237–245.CrossRefGoogle ScholarPubMed
Cathcart, E. S. & Gonnerman, W. A. (1991). Fish oil fatty acids and experimental arthritis. Rheumatic Disease Clinics of North America 17, 235–242.CrossRefGoogle ScholarPubMed
Cave, W. T. (1991). ω3 Fatty acid diet on tumorigenesis in experimental animals. World Review of Nutrition and Dietetics 66, 462–476.CrossRefGoogle Scholar
Clark, K. J., Makrides, M., Neumann, M. A. & Gibson, R. A. (1992). Determination of the optimal ratio of linoleic acid to α-linolenic acid formulas. Journal of Pediatrics 20, S151–S158.CrossRefGoogle Scholar
Clark, W. F., Parbtani, A., Huff, M. W., Reid, B., Holub, B. J. & Falardeau, P. (1989). Omega-3 fatty acid dietary supplementation in systemic lupus erythematosus. Kidney International 36, 653–660.CrossRefGoogle ScholarPubMed
Cleland, L. G., French, J. K., Betts, W. H., Murphy, G. A. & Elliott, M. J. (1988). Clinical and biochemical effects of dietary fish oil supplements in rheumatoid arthritis. Journal of Rheurnatology 15, 1471–1475.Google ScholarPubMed
Cobiac, L., Nestel, P., Wing, L. M. H. & Howe, P. R. C. (1991). The effects of dietary sodium restriction and fish oil supplementation on blood pressure in the elderly. Clinical and Experimental Pharmacology & Physiology 18, 265–268.CrossRefGoogle ScholarPubMed
Cooper, A. L., Weddell, K., Sanders, T. A. B. & Rothwell, N. J. (1992). Metabolic responses to interleukin 1 (IL-1) are attenuated by n−3 fatty acids in the rat. Proceedings of the Nutrition Sociery 51, 98A.Google Scholar
Dallongeville, J., Boulet, L., Davignon, J. & Lussier-Cacan, S. (1991). Fish oil supplementation reduces p-very low density lipoprotein in Type III dysbetalipoproteinemia. Arteriosclerosis and Thrombosis 11, 864–871.CrossRefGoogle ScholarPubMed
Danse, L. H. & Verschuren, P. M. (1978). Fish oil-induced yellow fat disease in rats. Veterinary Pathology 15, 544–548.CrossRefGoogle ScholarPubMed
Davidson, M. H., Burns, J. H., Subbaiah, P. V., Conn, M. E. & Drennan, K. B. (1991). Marine oil capsule therapy for the treatment of hyperlipidemia. Annals of Internal Medicine 151, 1732–1740.CrossRefGoogle ScholarPubMed
DeCaterina, R., Giannessi, D., Mazzone, A., Bernini, W., Lazzerini, G., Maffei, S., Cerri, M., Salvatore, L. & Weksler, B. (1990). Vascular prostacyclin is increased in patients ingesting ω-3 polyunsaturated fatty acids before coronary artery bypass graft surgery. Circulation 82, 428–438.CrossRefGoogle ScholarPubMed
de Knijff, P., Johansen, L. G., Rosseneu, M., Frants, R. R., Jespersen, J. & Havekes, L. M. (1992). Lipoprotein profile of a Greenland Inuit population. Arteriosclerosis and Thrombosis 12, 1371–1379.CrossRefGoogle ScholarPubMed
Edwards, I. J., Gebre, A. K., Wagner, W. D. & Parks, J. S. (1991). Reduced proteoglycan binding of low density lipoproteins from monkeys (Macaca fascicularis) fed a fish oil versus lard diet. Arteriosclerosis and Thrombosis 11, 1778–1785.CrossRefGoogle ScholarPubMed
Endres, S., Ghorbani, R.. Kelley, V. E., Georgilis, K., Lonnemann, G., van der Meer, J. W., Cannon, J. G., Rogers, T. S., Klempner, M. S., Weber, P. C., Schaefer, E. J., Wolff, S. M. & Dinarello, C. A. (1989). The effect of dietary supplementation with n−3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. New England Journal of Medicine 320, 265–271.CrossRefGoogle ScholarPubMed
Farquarson, J., Cockburn, F., Patrick, W. A., Jamieson, E. C. & Logan, R. W. (1992). Infant cerebral cortex phospholipid fatty-acid composition and diet. Lancet 340, 810–813.CrossRefGoogle Scholar
Fincham, J. E., Gouws, E., Woodroof, M. J., van Wyk, M. J., Kruger, N., Snuts, C. M., van Jaarsveld, P. J., Taljaraard, J. J. F., Schall, R., Straus, J. A. D. W. & Benade, A. J. S. (1991). Atherosclerosis chronic effects of fish oil and a therapeutic diet in non-human primates. Arteriosclerosis 11, 719–732.CrossRefGoogle Scholar
Fox, P. L. & DiCorletto, P. E. (1988). Fish oils inhibit endothelial cell production of platelet-derived growth factor-like protein. Science 241, 453–456.CrossRefGoogle ScholarPubMed
Friday, K. E., Failor, R. A., Childs, M. T. & Bierman, E. L. (1991). Effects of n−3 and n−6 fatty acid enriched diets on plasma lipoproteins and apolipoproteins in heterozygous familial hypercholesterolemia. Arteriosclerosis and Thrombosis 11, 47–54.CrossRefGoogle ScholarPubMed
Fumeron, F., Brigant, L., Ollivier, V., Prost, D. D., Driss, F., Darcet, P., Bard, J., Parra, H., Fruchart, J. & Apfelbaum, N. (1991). n−3 Polyunsaturated fatty acids raise low-density lipoproteins, high density lipoprotein 2, and plasminogen-activator inhibitor in healthy young men. American Journal of Clinical Nutrition 54, 118–122.CrossRefGoogle ScholarPubMed
Gries, A., Malle, H. & Kostner, G. M. (1990). Influence of dietary fish oils on plasma Lp(a) levels. Thrombosis Research 58, 667–668.CrossRefGoogle ScholarPubMed
Harris, W. S. (1989). Fish oils and plasma lipid and lipoprotein metabolism in humans: a critical review. Journal of Lipid Research 30, 785–807.CrossRefGoogle ScholarPubMed
Harris, W. S., Connor, W. E., Illingworth, D. R., Rothrock, D. W. & Foster, D. M. (1990). Effects of fish oil on VLDL triglyceride kinetics in humans. Journal of Lipid Research 31, 1549–1558.CrossRefGoogle ScholarPubMed
Harris, W. S., Connor, W. E. & Lindsey, S. (1984). Will dietary omega-3 fatty acids change the composition of human milk? American Journal of Clinical Nutrition 40, 780–785.CrossRefGoogle ScholarPubMed
Harris, W. S., Silveira, S. & Dujovne, C. A. (1990). The combined effects of n−3 fatty acids and aspirin on hemostatic parameters in man. Thrombosis Research 57, 517–526.CrossRefGoogle ScholarPubMed
Harris, W. S., Zucker, M. L. & Dujovne, C. A. (1988). ω-3 fatty acids in hypertriglyceridemic patients: triglycerides vs methyl esters. American Journal of Clinical Nutrition 48, 992–997.CrossRefGoogle ScholarPubMed
Hansen Hart, J. P., Hancke, S. & Petersen Moller, J. (1990). Atherosclerosis in native Greenlanders: an ultrasonic investigation. Archives of Medical Research 49, 151–156.Google Scholar
Hawthorne, A. B., Daneshmend, T. K., Hawkey, C. J., Belluzzi, A., Everitt, S. J., Holmes, G. K., Malkinson, C., Shaheen, M. Z. & Willars, J. E. (1992). Treatment of ulcerative colitis with fish oil supplementation: a prospective 12 month randomised controlled trial. Gut 33, 922–928.CrossRefGoogle ScholarPubMed
Hinds, A. & Sanders, T. A. B. (1993). The effect of increasing levels of dietary fish oil rich in eicosapentaenoic and docosahexaenoic acids on lymphocyte phospholipid fatty acid composition and cell-mediated immunity in the mouse. British Journal of Nutrition 69, 423–429.CrossRefGoogle Scholar
Holroyde, C. P., Skutches, C. L. & Reichard, G. A. (1988). Effect of dietary enrichment with n−3 polyunsaturated fatty acid (PUFA) in metastatic breast cancer. Proceedings of the Society of Experimental Oncology 7, 42.Google Scholar
Huff, M. W. & Telford, D. E. (1989). Dietary fish oil increases conversion of very low density lipoprotein apoprotein B to low density lipoprotein. Arteriosclerosis 9, 58–66.CrossRefGoogle ScholarPubMed
Iacoviello, L., Amore, C., Curtis, A. D., Tacconi, M. T., Gaetano, G. T., Cerletti, C. & Donati, M. B. (1992). Modulation of fibrinolytic response to venous occlusion in humans by a combination of low-dose aspirin and n−3 polyunsaturated fatty acids. Arteriosclerosis and Thrombosis 12, 1191–1197.CrossRefGoogle Scholar
Innis, S. M. & Kuhnlein, H. V. (1984). Long-chain n−3 fatty acids in breast milk of Inuit women consuming traditional foods. Early Human Development 18, 185–189.CrossRefGoogle Scholar
Juan, H. & Sametz, W. (1989). Fish oil diet rich in eicosapentaenoic acid increases bleeding time in the rat by interaction with sympathetic transmitters. Agents Actions 28, 130–136.CrossRefGoogle Scholar
Kestin, P., Clifton, P., Belling, G. B. & Nestle, P. J. (1990). n−3 Fatty acids of marine origin lower systolic blood pressure and triglycerides but raise LDL cholesterol compared with n−3 and n−6 fatty acids from plants. American Journal of Clinical Nutrition 51, 1028–1034.CrossRefGoogle ScholarPubMed
Knapp, H. R. (1990). Prostaglandins in human semen during fish oil ingestion: evidence for in vivo cyclooxygenase inhibition and appearance of novel trienoic compounds. Prostaglandins 39, 407–423.CrossRefGoogle ScholarPubMed
Knapp, H. R. & Fitzgerald, G. A. (1989). The antihypertensive effects of fish oil. A controlled study of polyunsaturated fatty acid supplements in essential hypertension. New England Journal of Medicine 320, 1037–1043.CrossRefGoogle ScholarPubMed
Kremer, J. M., Jubiz, W., Michalek, A., Rynes, R. I., Bartholmew, L. E., Bigaoutte, J., Timchalk, J. M., Beeler, D. & Lininger, L. (1987). Fish oil fatty acid supplementation in active rheumatoid arthritis: a double-blinded, controlled crossover study. Annals of Internal Medicine 106, 497–503.CrossRefGoogle ScholarPubMed
Kremer, J. M., Lawrence, D. A, Jubiz, W., DiGiacomo, R., Rynes, R., Bartholomew, L. E. & Sherman, M. (1990). Dietary fish oil and olive oil supplementation in patients with rheumatoid arthritis. Clinical and immunologic effects. Arthritis and Rheumatism 33, 810–820.CrossRefGoogle ScholarPubMed
Kremer, J. M., Michalek, A. V., Lininger, L., Huyck, C., Bigauoutte, J., Timchalk, M. A., Rynes, R. I., Zieminski, J. & Bartholomew, L. E. (1985). Effects of manipulation of dietary fatty acids on clinical manifestations of rheumatoid arthritis. Lancet i, 184–197.CrossRefGoogle Scholar
Lam, J. Y., Badimon, J. J., Ellefson, R. D., Fuster, V. & Chesebro, J. H. (1992). Cod liver oil alters platelet-arterial wall response to injury in pigs. Circulation Research 71, 769–775.CrossRefGoogle ScholarPubMed
Lassus, A., Dahlgren, A. L., Halpern, M. J., Santalahti, J. & Happonen, H. P. (1990). Effects of dietary supplementation with polyunsaturated ethyl ester lipids (Angiosan) in patients with psoriasis and psoriatic arthritis. Journal of Internal Medical Research 18, 68–73.Google ScholarPubMed
Leaf, A. & Weber, P. C. (1988). Cardiovascular effects of n−3 fatty acids. New England Journal of Medicine 318, 549–557.CrossRefGoogle Scholar
Lehr, H. A., Hubner, C., Finckh, B., Nolte, D., Beisiegel, U., Kohlschutter, A. & Messmer, K. (1991). Dietary fish oil reduces leukocyte/endothelium interaction following system administration of oxidatively modified low density lipoprotein. Circulation 84, 1725–1731.CrossRefGoogle Scholar
Lei, X. L. & Steiner, M. (1991). Dose response of dietary fish oil supplementations on platelet adhesion. Arteriosclerosis and Thrombosis 11, 39–46.CrossRefGoogle Scholar
Lindsey, S., Pronczuk, A. & Hayes, K. C. (1992). Low density lipoprotein from humans supplemented with n−3 fatty acids depresses both LDL receptor activity and LDLr mRNA abundance in HepG2 cells. Journal of Lipid Research 33, 647–658.CrossRefGoogle ScholarPubMed
Liu, C. C., Carlson, S. E., Rhodes, P. G., Rao, V. S. & Meydrech, E. F. (1987). Increase in plasma phospholipid docosahexaenoic and eicosapentaenoic acids as a reflection of their intake and mode of administration. Pediatric Research 22, 292–296.Google ScholarPubMed
Lucas, A., Morley, R., Cole, T. J., Lister, G. & Leeson-Payne, C. (1992). Breast milk and subsequent intelligence quotient in children born pre-term. Lancet 339, 261–264.CrossRefGoogle Scholar
McLennan, P. L., Bridle, T. M., Abeywardena, M. Y. & Charnock, J. S. (1992). Dietary lipid modulation of ventricular fibrillation threshold in the marmoset monkey. American Heart Journal 123, 1555–1561.CrossRefGoogle ScholarPubMed
Maurice, P. D. L., Allen, B. R., Barkley, A. S. J., Cockbill, S. R., Stammers, J. & Bather, P. C. (1987). The effects of dietary supplementation with fish oil in patients with psoriasis. British Journal of Dermatolology 117, 599–606.CrossRefGoogle ScholarPubMed
Molgaard, J., von Schenck, H. V., Lassvik, C. L., Kuusi, T. & Olsson, A. G. (1990). Effect of fish oil treatment on plasma lipoproteins in type III hyperlipoproteinaemia. Atherosclerosis 81, 1–9.CrossRefGoogle ScholarPubMed
Nenseter, M. S., Rustan, A. C., Lund-Katz, S., Soyland, E., Maelandsmo, G., Phillipis, M. C. & Drevon, C. A. (1992). Effect of dietary supplementation with n−3 polyunsaturated fatty acids on the physical properties and metabolism of low density lipoproteins in humans. Arteriosclerosis and Thrombosis 12, 369–379.CrossRefGoogle ScholarPubMed
Neuringer, M., Anderson, G. J. & Connor, W. E. (1988). The essentiality of ω3 fatty acids for the development and function of the retina and brain. Annual Reviews in Nutrition 8, 517–541.CrossRefGoogle Scholar
O'Connor, G. T., Olmstead, E. M., Johnson, P. S. & Hennekens, C. H. (1992). A meta-analysis of randomized trials of fish oil in prevention of restenosis following coronary angioplasty. American Journal of Preventative Medicine 8, 186–192.CrossRefGoogle ScholarPubMed
Olsen, S. F., Sørensen, J. D., Secher, N. J., Hedegaard, M., Henriksen, T. B., Hansen, H. S. & Grant, A. (1992). Randomised controlled trial of effect of fish-oil supplementation on pregnancy duration. Lancet 339, 1003–1007.CrossRefGoogle ScholarPubMed
Parks, J.S., Kaduck-Sawyer, J., Bullock, B. C. & Rudel, L. L. (1990). Effect of dietary fish oil on coronary artery and aortic atherosclerosis in African green monkeys. Arteriosclerosis 10, 1102–1112.CrossRefGoogle ScholarPubMed
Pollard, L. & Sanders, T. A. B. (1993). Estimates of the vitamin E requirement in rats fed long-chain n−3 fatty acids. Proceedings of the Nutrition Society 52, 319A.Google Scholar
Rapp, J. H., Connor, W. E., Lin, D. S. & Porter, J. M. (1991). Dietary eicosapentaenoic acid and docosahexaenoic acid from fish oil. Their incorporation into advanced human atherosclerotic plaques. Arteriosclerosis and Thrombosis 11, 903–911.CrossRefGoogle ScholarPubMed
Reddy, S., Sanders, T. A. B. & Obeid, O. (1993). The influence of maternal diet on essential fatty acid status of the newborn. European Journal of Clinical Nutrition (In the Press.)Google Scholar
Reisbeck, S., Neuringer, M. & Connor, W. E. (1992). Postnatal deficiency of omega-3 fatty acids in monkeys: fluid intake and urine concentration. Physiology and Behaviour 51, 473–479.CrossRefGoogle Scholar
Robinson, D. R. (1991). Alleviation of autoimmune disease by dietary lipids containing omega-3 fatty acids. Rheumatic Disease Clinics of North America 17, 213–222.CrossRefGoogle ScholarPubMed
Sanders, T. A. B. (1988). Essential and trans fatty acids in nutrition. Nutrition Research Reviews 1, 57–78.CrossRefGoogle ScholarPubMed
Sanders, T. A. B. (1991). Influence of ω3 fatty acids on blood lipids. World Review of Nutrition and Dietetics 66, 358–366.CrossRefGoogle Scholar
Sanders, T. A. B. & Hinds, A. (1992). The influence of a fish oil high in docosahexaenoic acid on plasma lipoprotein and vitamin E concentrations and haemostatic function in healthy male volunteers. British Journal of Nutrition 68, 163–173.CrossRefGoogle ScholarPubMed
Sanders, T. A. B., Hinds, A. & Perreira, C. C. (1989). Influence of n−3 fatty acids on blood lipids in normal subjects. Journal of Internal Medicine 225, Suppl. 1, 99–104.CrossRefGoogle Scholar
Sanders, T. A. B. & Reddy, S. (1992). The influence of a vegetarian diet on the fatty acid composition of human milk and the essential fatty acid status of the infant. Journal of Pediatrics 120, S71–S77.CrossRefGoogle ScholarPubMed
Sarris, G. E., Fann, J. I., Sokoloff, M. H., Smith, D. L., Loveday, M., Kosek, J. C., Stephens, R. J., Cooper, A. D., May, K. & Willis, A. L. (1989). Mechanisms responsible for inhibition of vein-graft arteriosclerosis by fish oil. Circulation 80, I-109–I-123.Google ScholarPubMed
Shimokawa, H. & van Houte, P. M. (1988). Dietary cod-liver oil improves endothelium-dependent responses in hypercholesterolemia and atherosclerotic porcine coronary arteries. Circulation 78, 1421–1430.CrossRefGoogle ScholarPubMed
Singer, P., Jaeger, W., Berger, I., Barleben, H., Wirth, M., Richter-Heinrich, E., Voigt, S. & Godicke, W. (1990). Effects of dietary oleic, linoleic and α-linolenic acids on blood pressure, serum lipids, lipoproteins and the formation of eicosanoid precursors in patients with mild essential hypertension. Journal of Human Hypertension 4, 227–233.Google ScholarPubMed
Skoldstam, L., Borjesson, O., Kjallman, A, Seiving, B. & Akesson, B. (1992). Effect of six months of fish oil supplementation in stable rheumatoid arthritis. A double-blind, controlled study. Scandinavian Journal of Rheumatology 21, 178–185.CrossRefGoogle ScholarPubMed
Sorci-Thomas, M., Hendricks, C. L. & Kearns, M. W. (1992). HepG2 cell LDL receptor activity and the accumulation of apolipoprotein B and E in response to docosahexaenoic acid and cholesterol. Journal of Lipid Research 33, 1147–1156.CrossRefGoogle Scholar
Stammers, T., Sibbald, B. & Freeling, P. (1992). Efficacy of cod liver oil as an adjunct to non-steroidal anti-inflammatory drug treatment in the management of osteoarthritis in general practice. Annals of Rheumatic Diseases 51, 128–129.CrossRefGoogle ScholarPubMed
Terano, T., Salmon, J. A, Higg, G. A. & Moncada, S. (1986). Eicosapentaenoic acid as a modulator of inflammation. Effect on prostaglandin and leukotriene synthesis. Biochemical Pharmacology 35, 779–785.CrossRefGoogle Scholar
Tisdale, M. J. & Beck, S. (1991). Inhibition of tumour-induced lipolysis in vitro and cachexia and tumour growth in vivo by eicosapentaenoic acid. Biochemical Pharmacology 41, 103–107.CrossRefGoogle ScholarPubMed
Tisdale, M. J. & Dhesi, J. M. (1990). Inhibition of weight loss by n−3 fatty acids in an experimental cachexia model. Cancer Research 50, 5022–5026.Google Scholar
Trocki, O., Heyd, T. J., Waymack, J. P. & Alexander, J. W. (1987). Effects of fish oil on postburn metabolism and immunity. Journal of Parenteral and Enteral Nutrition 11, 521–528.CrossRefGoogle ScholarPubMed
Uauy, R. D., Birch, D. G., Birch, E. E., Tyson, J. E. & Hoffman, D. R. (1990). Effect of dietary omega-3 fatty acids on retinal function of very low birth weight neonates. Pediatric Research 28, 485–492.CrossRefGoogle ScholarPubMed
van Houte, P. M., Shimokawa, H. & Boulanger, C. (1991). Fish oil and the platelet-blood vessel wall interaction. World Review of Nutrition and Dietetics 66, 233–244.CrossRefGoogle Scholar
Van Houwelingen, R., Nordoy, A., Van der Beek, E., Houtsmuller, U., de Metz, M. & Hornstra, G. (1987). Effect of a moderate fish intake on blood pressure, bleeding times, hematology, and clinical chemistry in healthy males. American Journal of Clinical Nutrition 46, 424–436.CrossRefGoogle Scholar
Vessby, B. & Boberg, M. (1990). Supplementation with n−3 fatty acids may impair glucose homeostasis in patients with non-insulin-dependent diabetes mellitus. Journal of Internal Medicine 228, 165–171.CrossRefGoogle ScholarPubMed
Walton, A. J., Snaith, M. L., Locniskar, M., Cumberland, A. G., Morrow, W. J. & Isenberg, D. A. (1991). Dietary fish oil and the severity of symptoms in patients with systemic lupus erythematosus. Annals of Rheumatic Diseases 50, 463–466.CrossRefGoogle ScholarPubMed
Westberg, G. & Tarkowski, A. (1990). Effect of MaxEPA in patients with SLE. Scandinavian Journal of Rheumatology 19, 137–143.CrossRefGoogle ScholarPubMed
Yamamoto, N., Saitoh, M., Moriuchi, A., Nomura, M. & Okuyama, H. (1987). Effect of dietary α-linolenate/linoleate balance on brain lipid compositions and learning ability of rats. Journal of Lipid Research 28, 144–151.CrossRefGoogle ScholarPubMed
Ziboh, V.A, Cohen, K. A, Ellis, C. N., Miller, C., Hamilton, T. A., Kragballe, K., Hydrick, C. R. & Voorhess, J. J. (1986). Effects of dietary supplementation of fish oils on neutrophil and epidermal fatty acids: modulation of clinical course of psoriatic subjects. Archives of Dermatology 122, 1277–1282.CrossRefGoogle ScholarPubMed