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Methodological approaches to assess body-weight regulation and aetiology of obesity

Published online by Cambridge University Press:  28 February 2007

Amelia Marti ,
Carlos De Miguel ,
Susan A Jebb ,
Max Lafontan ,
Martine Laville ,
Andreu Palou ,
Xavier Remesar ,
Paul Trayhurn  and
J. Alfredo Martinez
Amelia Marti*
Affiliation:
Department of Physiology and Nutrition, University of Navarra, 31008 Pamplona, Spain
Carlos De Miguel
Affiliation:
Department of Biochemistry and Molecular Biology, University of Navarra, 31008 Pamplona, Spain
Susan A Jebb
Affiliation:
MRC Human Nutrition Research, Downhams Lane, Cambridge CB4 1XJ, UK
Max Lafontan
Affiliation:
Unité INSERM 317, Institut Louis Bugnard, Université Paul Sabatier, CHU Rangueil, 31403 Toulouse cedex 4, France
Martine Laville
Affiliation:
Human Nutrition Research Centre of Lyon, INSERM U 449, Lyon, France
Andreu Palou
Affiliation:
Bioquímica i Biologia Molecular, Department de Biologia Molecular, Departament de Biologia Fonamental i Ciències de la Salut, Universitat de les IllesBalears, 07071-Palma de Mallorca, Spain
Xavier Remesar
Affiliation:
Department of Biochemistry and Molecular Biology, Faculty of Biology, >University of Barcelona, Barcelona, Spain
Paul Trayhurn
Affiliation:
Molecular Physiology Group, Rowett Research Institute, Bucksburn, Aberdeen AB21 9SB, UK
J. Alfredo Martinez
Affiliation:
Department of Physiology and Nutrition, University of Navarra, 31008 Pamplona, Spain
*
*Corresponding author: Dr Amelia Marti, fax +34 948 425649, email amarti@unav.es
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Abstract

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Obesity, which is becoming one of the major health hazards in developed and developing societies, results from a long-term positive energy balance. Body-weight regulation and stability depend on an axis with three interrelated components: food intake, energy expenditure and adipogenesis, although there are still many unknown features concerning fuel homeostasis and energy balance. Biochemical processes are interconnected, and a separate consideration of each component is often useful for methodological purposes and to achieve a better understanding of the whole system. Thus, many different experimental approaches can be applied by using laboratory animals, cell culture or human subjects to unravel the molecular mechanisms which participate in body-weight regulation. Thus, both in vitro (cellular and subcellular models) and in vivo methods have dramatically increased our knowledge of weight control. Several strategies in obesity research are reported here, exploiting the opportunities of the molecular era as well as novel whole-body approaches, which will impact on the development of new targets for obesity management and prevention.

Keywords

Obesity genesAdipose tissueEnergy expenditureBody composition
Type
4th Plenary Session (Debate) on ‘Methodological approaches in body-weight regulation’
Information
Proceedings of the Nutrition Society , Volume 59 , Issue 3 , August 2000 , pp. 405 - 411
Copyright
Copyright © The Nutrition Society 2000

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