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Micronutrient fortification of plants through plant breeding: can it improve nutrition in man at low cost?

Published online by Cambridge University Press:  05 March 2007

Howarth E. Bouis
Howarth E. Bouis*
Affiliation:
International Food Policy Research Institute, 2033 K St NW, Washington DC 20006, USA
*
Corresponding author: Dr Howarth E. Bouis, fax +1 202 467 4439, h.bouis@cgiar.org
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Abstract

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Can commonly-eaten food staple crops be developed that fortify their seeds with essential minerals and vitamins? Can farmers be induced to grow such varieties? If so, would this result in a marked improvement in human nutrition at a lower cost than existing nutrition interventions? An interdisciplinary international effort is underway to breed for mineral- and vitamin-dense varieties of rice, wheat, maize, beans and cassava for release to farmers in developing countries. The biofortification strategy seeks to take advantage of the consistent daily consumption of large amounts of food staples by all family members, including women and children as they are most at risk for micronutrient malnutrition. As a consequence of the predominance of food staples in the diets of the poor, this strategy implicitly targets low-income households. After the one-time investment is made to develop seeds that fortify themselves, recurrent costs are low and germplasm may be shared internationally. It is this multiplier aspect of plant breeding across time and distance that makes it so cost-effective. Once in place, the biofortified crop system is highly sustainable. Nutritionally-improved varieties will continue to be grown and consumed year after year, even if government attention and international funding for micronutrient issues fades. Biofortification provides a truly feasible means of reaching malnourished populations in relatively remote rural areas, delivering naturally-fortified foods to population groups with limited access to commercially-marketed fortified foods that are more readily available in urban areas. Biofortification and commercial fortification are, therefore, highly complementary. Breeding for higher trace mineral density in seeds will not incur a yield penalty. Mineral-packed seeds sell themselves to farmers because, as recent research has shown, these trace minerals are essential in helping plants resist disease and other environmental stresses. More seedlings survive and initial growth is more rapid. Ultimately, yields are higher, particularly in trace mineral-‘deficient’ soils in arid regions.

Keywords

BiofortificationPlant breeding strategyHuman micronutrient statusBiofortification v. commercial fortification
Type
Micronutrient Group Symposium on ‘Micronutrient supplementation: when and why?’
Information
Proceedings of the Nutrition Society , Volume 62 , Issue 2 , May 2003 , pp. 403 - 411
Copyright
Copyright © The Nutrition Society 2003

References

ACC/SCN (2000) Fourth Report on the World Nutrition Situation Geneva ACC/SCN/International Food Policy Research InstituteGoogle Scholar
Beaton, GH, Martorell, R, Aronson, KJ, Edmonston, B, McCabe, G, Ross, AC & Harvey, B (1993) Effectiveness of Vitamin A Supplementation in the Control of Young Child Morbidity and Mortality in Developing Countries. ACC/SCN State-of-the-Art Series, Nutrition Policy Discussion Paper no. 13 Geneva ACC/SCNGoogle Scholar
Beyer, P, Al-Babili, S, Ye, X, Lucca, P, Schaub, P, Welsch, R & Potrykus, I (2002) Golden rice: Introducing the β-carotene biosynthesis pathway into rice endosperm by genetic engineering to defeat vitamin A deficiency. Journal of Nutrition 132, 506–510Google Scholar
Bhargava, A, Bouis, H & Schrimshaw, N (2001) Dietary intakes and socioeconomic factors are associated with the hemoglobin concentration of Bangladeshi women. Journal of Nutrition 131, 758–764CrossRefGoogle ScholarPubMed
Bhutta, ZA, Bird, SM, Black, RE, Brown, KH, Gardner, JM, Hidayat, A, Khatun, F, Martorell, R, Ninh, NX, Penny, ME, Rosado, JL, Roy, SK, Ruel, M, Sazawal, S & Shankar, A (2000) Therapeutic effects of oral zinc in acute and persistent diarrhoea in children in developing countries: Pooled analysis of randomized controlled trial. Zinc Investigators' Collaborative Group. American Journal of Clinical Nutrition 72, 1516–1522CrossRefGoogle Scholar
Bhutta, ZA, Black, RE, Brown, KH, Gardner, JM, Gore, S, Hidayat, A, Khatun, F, Martorell, R, Ninh, NX, Penny, ME, Rosado, JL, Roy, SK, Ruel, M, Sazawal, S & Shankar, A (1999) Prevention of diarrhea and pneumonia by zinc supplementation in children in developing countries: Pooled analysis of randomized controlled trials. Zinc Investigators' Collaborative Group. Journal of Pediatrics 135, 689–697CrossRefGoogle ScholarPubMed
Black, RE (1998) Therapeutic and preventive effects of zinc on serious childhood infectious diseases in developing countries. American Journal of Clinical Nutrition 68 S476 – S479Google Scholar
Bouis, HE (2000) The role of biotechnology for food consumers in developing countries Agricultural Biotechnology in Developing Countries: Towards Optimizing Benefits for the Poor 189–213 Qaim M Krattiger M von Braun J Boston, MA Kluwer Academic PublishersGoogle Scholar
Bouis, H, de, la, Brière, B, Guitierrez, L, Hallman, K, Hassan, N, Hels, O, Quabili, W, Quisumbing, A, Thilsted, S, Zihad, Z & Zohir, S (1998) Commercial Vegetable and Polyculture Fish Production in Bangladesh: Impacts on Income, Household Resource Allocation, and Nutrition Washington, DC International Food Policy Research InstituteGoogle Scholar
Bouis, HE & Haddad, LJ (1990) Agricultural Commercialization, Nutrition, and the Rural Poor: A Study of Philippine Farm Households Boulder, CO Lynne Rienner PublishersCrossRefGoogle Scholar
Bouis, HE, Novenario-Reese, MJ (1997) The Determinants of Demand for Micronutrients: An Analysis of Rural Households in Bangladesh. Food Consumption and Nutrition Division Discussion Paper no. 32 Washington, DC International Food Policy Research InstituteGoogle Scholar
Brown, KH & Wuehler, SE (2000) Zinc and Human Health: Results of Recent Trials and Implications for Programme Interventions and Research Ottawa, Canada The Micronutrient Initiative/International Development Research CentreGoogle Scholar
Food, and & Agriculture, Organization (1999) FAOSTAT Agriculture Data. http://apps.fao.org/page/collections?subset=agriculture.Google Scholar
Glahn, RP, Cheng, Z, Welch, RM & Gregorio, GB (2002) Comparison of iron bioavailability from 15 rice genotypes: Studies using an in vitro digestion/Caco-2 culture model. Journal of Agricultural and Food Chemistry 50, 3586–3591CrossRefGoogle Scholar
Graham, RD (1978) Nutrient efficiency objectives in cereal breeding Proceedings of the 8th International Colloquium on Plant Analysis and Fertilizer Problems. New Zealand Division of Scientific and Industrial Research Information Series no. 134 165–170 Fergusen AR Bieleski RL Ferguson IB Wellington, New Zealand Government PrinterGoogle Scholar
Graham, RD (1991) Breeding wheats for tolerance to micronutrient deficient soil: Present status and priorities Wheat for the Nontraditional Warm Areas Saunders DA Mexico City, Mexico Centro Internacional de Mejoramiento de Maiz y TrigoGoogle Scholar
Graham, RD & Rovira, AD (1984) A role for manganese in the resistance of what to take-all. Plant and Soil 78, 441–444Google Scholar
Graham, RD, Senadhira, D, Beebe, SE, Iglesias, C, Ortiz-Monasterio, I (1999) Breeding for micronutrient density in edible portions of staple food crops: Conventional approaches. Field Crops Research 60, 57–80Google Scholar
Graham, RD & Welch, RM (1996) Breeding for Staple Food Crops with High Micronutrient Density. Agricultural Strategies for Micronutrients Working Paper 3 Washington, DC International Food Policy Research InstituteCrossRefGoogle Scholar
Graham, R, Welch, R & Bouis, H (2001) Addressing micronutrient malnutrition through the nutritional quality of staple foods: Principles, perspectives, and knowledge gaps. Advances in Agronomy 70, 77–142CrossRefGoogle Scholar
Hallberg, L (1981) Bioavailability of dietary iron in man. Annual Review of Nutrition 1, 123–127CrossRefGoogle ScholarPubMed
Holm, P, Kristiansen, KN & Pedersen, HB (2002) Transgenic approaches in commonly consumed cereals to improve iron and zinc content and bioavailability. Journal of Nutrition 132, 514–516CrossRefGoogle ScholarPubMed
Horton, S & Ross, J (1999) Economic Consequences of Iron Deficiency. Forthcoming Technical Paper Ottawa, Canada The Micronutrient InitiativeGoogle Scholar
Marschner, H (1995) Mineral Nutrition of Higher Plants 2nd ed. London Academic PressGoogle Scholar
Perry, GS, Yip, R & Zyrkowski, C (1995) Nutritional risk factors among low-income pregnant US women: The Centers for Disease Control and Prevention (CDC) Pregnant Nutrition Surveillance System, 1979–1993. Seminars in Perinatology 19, 211–221CrossRefGoogle Scholar
Raboy, V (2002) Progress in breeding low phytate crops. Journal of Nutrition 132, 503–505CrossRefGoogle ScholarPubMed
Rengel, Z & Graham, RD (1995a) Importance of seed Zn content for wheat growth on Zn-deficient soil: I. Vegetative growth. Plant and Soil 173, 259–266CrossRefGoogle Scholar
Rengel, Z & Graham, RD (1995b) Importance of seed Zn content for wheat growth on Zn-deficient soil: II. Grain yield. Plant and Soil 173, 267–274Google Scholar
Roy, SK, Tomkins, AM, Haider, R, Behren, RH, Akramuzzaman, SM, Mahalanabis, D & Fuchs, CJ (1999) Impact of zinc supplementation on subsequent growth and morbidity in Bangladeshi children with acute diarrhoea. European Journal of Clinical Nutrition 53, 529–534CrossRefGoogle ScholarPubMed
Shankar, AH, Genton, B, Baisor, M, Paino, J, Tamja, S, Adiguma, T, Wu, L, Rare, L, Bannon, D, Tielsch, JM, West, KP, Jr, Alpers MP (2000) The influence of zinc supplementation on morbidity due to Plasmodium malaria: A randomised trial in preschool children in Papua New Guinea. American Journal of Tropical Medicine and Hygiene 62, 663–669Google Scholar
Shankar, AH, Genton, B, Semba, RD, Baisor, M, Paino, J, Tamja, S, Adiguma, T, Wu, L, Rare, L, Tielsch, JM, Alpers, MP, West, KP Jr (1999) Effect of vitamin A supplementation on morbidity due to Plasmodium falciparum in young children in Papua New Guinea: A randomised trial. Lancet 354, 203–209Google Scholar
Sillanpä, M (1990) Micronutrient assessment at the country level: an international study. FAO Soils Bulletin 48 Rome FAOGoogle Scholar
Sommer, A & West, KP (1996) Vitamin A Deficiency: Health, Survival, and Vision New York Oxford University PressGoogle Scholar
Sparrow, DH & Graham, RD (1988) Susceptibility of zinc-deficient wheat plants to colonization by Fusarium graminearum Schw. Group 1. Plant and Soil 112, 261–266Google Scholar
Stoltzfus, RJ (2001) Defining iron-deficiency anemia in public health terms: A time for reflection. Journal of Nutrition 131 565S – 567SCrossRefGoogle ScholarPubMed
Thongbai, P, Hannam, RJ, Graham, RD & Webb, MJ (1993) Zinc nutrition and rhizoctoria root rot of cereals. Plant and Soil 153, 207–214Google Scholar
Umeta, M, West, CE, Haidar, J, Deurenberg, P & Hautvast, JG (2000) Zinc supplementation and stunted infants in Ethiopia: A randomised controlled trial. Lancet 355, 2021–2026Google Scholar
Villamor, E & Fawzi, WW (2000) Vitamin A supplementation: Implications for morbidity and mortality in children. Journal of Infectious Diseases 182 S122 – S133 Suppl. 1Google Scholar
Welch, RM (1986) Effects of nutrient deficiencies on seed production and quality. Advances in Plant Nutrition 2, 205–247Google Scholar
Welch, RM (1993) Zinc concentrations and forms in plants for humans and animals Zinc in Soils and Plants 183–195 Robson AD Boston, MA Kluwer Academic PublishersGoogle Scholar
Welch, RM (1995) Micronutrient nutrition of plants. Critical Reviews in Plant Sciences 14, 49–82CrossRefGoogle Scholar
Welch, RM (1999) Importance of seed mineral nutrient reserves in crop growth and development. In Mineral Nutrition of Crops: Micronutrient supplementation: when and why? Fundamental Mechanisms and Implications 205–226 Rengel Z New York Food Products PressGoogle Scholar
Welch, RM, House, WA, Beebe, S & Cheng, Z (2000) Genetic selection for enhanced bioavailable levels of iron in bean ( Phaseolus vulgaris L.) seeds. Journal of Agricultural and Food Chemistry 48, 3576–3580Google Scholar
West, CE (2000) Vitamin A and measles. Nutrition Reviews 58 S46 – S54Google Scholar
Wise, A (1995) Phytate and zinc bioavailability. International Journal of Food Sciences and Nutrition 46, 53–63Google Scholar
World, Bank (1994) Enriching Lives: Overcoming Vitamin and Mineral Malnutrition in Developing Countries. Development in Practice Series Washington, DC World BankGoogle Scholar
Yang, X, Römheld, V (1999) Physiological and genetic aspects of micronutrient uptake by higher plants Plant Nutrition – Molecular Biology and Genetics. Proceedings of the Sixth International Symposium on Genetics and Molecular Biology of Plant Nutrition 151–186 Gissel-Nielsen G Jensen A Dordrecht, The Netherlands Kluwer Academic PublishersGoogle Scholar