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Of mice and men: genetic determinants of iron status

Published online by Cambridge University Press:  07 March 2007

Johanne McGregor ,
Andrew T. McKie  and
Robert J. Simpson
Johanne McGregor
Affiliation:
Division of Life Sciences, King's College London, London, SE1 9NN, UK
Andrew T. McKie
Affiliation:
Division of Life Sciences, King's College London, London, SE1 9NN, UK
Robert J. Simpson*
Affiliation:
Division of Life Sciences, King's College London, London, SE1 9NN, UK
*
Corresponding author: Dr Robert Simpson, fax 44 20 7848 4500, email robert.simpson@kcl.ac.uk
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Abstract

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Fe homeostasis is maintained by regulation of Fe absorption to balance largely unregulated body Fe losses. The majority of human subjects maintain relatively constant Fe stores; however, Fe deficiency and Fe overload are common conditions. Fe overload is frequently associated with mutations in genes of Fe metabolism. The present paper summarises present knowledge of these mutations as well as indicating other genes that animal studies have implicated as candidates for influencing body Fe stores.

Keywords

Iron overloadIron deficiencyIron absorption
Type
Meeting Report
Information
Proceedings of the Nutrition Society , Volume 63 , Issue 1 , February 2004 , pp. 11 - 20
Copyright
Copyright © The Nutrition Society 2004

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