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Oral health and nutritional biochemical variables in adult patients with AIDS

Published online by Cambridge University Press:  12 May 2008

N. Slobodianik ,
P. Perris ,
A. Squassi ,
G. Sánchez ,
M. S. Feliu  and
N. Bordoni
N. Slobodianik
Affiliation:
Department of Nutrition, School of Pharmacy and Biochemistry
P. Perris
Affiliation:
Department of Nutrition, School of Pharmacy and Biochemistry
A. Squassi
Affiliation:
Oral Care Clinic for High Risk Patients (CLAPAR I), University of Buenos Aires, Argentina School of Dentistry, University of Buenos Aires, Argentina
G. Sánchez
Affiliation:
Oral Care Clinic for High Risk Patients (CLAPAR I), University of Buenos Aires, Argentina School of Dentistry, University of Buenos Aires, Argentina
M. S. Feliu
Affiliation:
Department of Nutrition, School of Pharmacy and Biochemistry
N. Bordoni
Affiliation:
School of Dentistry, University of Buenos Aires, Argentina
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Abstract

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Type
1st International Immunonutrition Workshop, Valencia, 3–5 October 2007, Valencia, Spain
Information
Proceedings of the Nutrition Society , Volume 67 , Issue OCE1: 1st International Immunonutrition Workshop, Valencia, 3–5 October 2007, Valencia, Spain , May 2008 , E19
Copyright
Copyright © The Authors 2008

High prevalence of oral disease has been observed in patients with AIDS(Reference MacPhail and Greenspan1–Reference Fidel3). The aim of this preliminary study was to analyse oral health and its relationship with nutritional biochemical variables in a group of adult patients with AIDS. Twenty-eight patients between 25 and 50 years old who were HIV+ were included. Dental status, gingival status and presence of mucosal alterations were determined. The DMFT index (decayed, missed and filled teeth) and its components (gingival index, bleeding sites and the presence of erosion on soft tissues) were calculated and evaluated(Reference Loe4). Samples of whole blood and non-stimulated saliva were collected from fasting patients and serum transthyretin (TTR), C3c fraction (C3c) and total saliva IgA levels were determined by quantitative radial immunodiffusion on layers (The Binding Site, Birmingham, UK and Diffuplate; Biocientifica, Buenos Aires, Argentina)(Reference Mancini, Carbonara and Heremans5–Reference Slobodianik and Feliu7). The results were (mg/l): IgA 82 (sd 41); TTR 271 (sd 177); C3c 828 (sd 380). When results were compared with reference values (227 (sd 74), 337 (sd 92) and 1350 (sd 270) respectively) a reduction in levels was observed. Moreover, also observed were: (a) a negative correlation between the D component of DMFT and the number of bleeding sites and TTR levels (r −0.68, P<0.001); (b) a positive correlation between the presence of lesions on soft tissues and the concentration of total IgA in saliva (r 0.84, P<0.001). No correlation between gingival index and biochemical variables was observed. The results suggest a compromised nutritional status concomitant with alterations in oral health in the study group.

This work was partially supported by the University of Buenos Aires (Grants B060 and O750).

References

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