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Psychological underpinnings of metabolic syndrome

Published online by Cambridge University Press:  07 March 2007

Barbara J. Stewart-Knox
Barbara J. Stewart-Knox
Affiliation:
Northern Ireland Centre for Food and Health (NICHE), University of Ulster, Coleraine BT52 1SA, UK
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Abstract

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Metabolic syndrome (MS) is more common among socio-economically disadvantaged individuals and is associated with certain risky lifestyle practices. MS also appears to be triggered by adverse social circumstances and chronic stress. The present paper reviews accumulating evidence to imply that individuals who have certain personality and behaviour traits are particularly predisposed to develop MS, and brings together theories that relate to possible psychological mechanisms underlying MS. It considers how such factors might interact causally to encourage the development of MS. As part of the EU-funded LIPGENE Integrated Project, multi-level modelling will be undertaken to explore potential pathways to MS, taking into consideration the interplay between a range of psycho-social, demographic, cultural and lifestyle factors thought to contribute to the development of MS. Data will be gathered for this purpose from a representative sample of >50-year-olds living in Britain (n 1000) and Portugal (n 500). It is anticipated that this information will assist in the development and targetting of future intervention to prevent and treat MS in the normal population.

Keywords

Metabolic syndromePsychologicalSocialDemographicCultural
Type
Meeting Report
Information
Proceedings of the Nutrition Society , Volume 64 , Issue 3 , August 2005 , pp. 363 - 369
Copyright
Copyright © The Nutrition Society 2005

References

Almeras, N, Despres, JP, Villeneuve, J, Demers, MF, Roy, MA, Cadrin, C, Mottard, JP & Bouchard, RH (2004) Development of an atherogenic metabolic risk factor profile associated with the use of atypical antipsychotics. Journal of Clinical Psychiatry 65, 557–564 CrossRefGoogle ScholarPubMed
Baptista, T (1999) Body weight gain induced by anti-psychotic drugs: mechanisms and management. Acta Psychiatrica Scandinavica 100, 3–16 Google Scholar
Barefoot, JC, Peterson, BL, Dahlstrom, WG, Siegler, IC, Anderson, NB & Williams, RB (1991) Hostility patterns and health implications: correlates of Cook-Medley Hostility Scale Scores in a national survey. Health Psychology 10, 18–24 CrossRefGoogle ScholarPubMed
Basu, R, Brar, JS, Chengappa, KNR, John, V, Parepally, H, Gershon, S, Schlicht, P & Kupfer, DJ (2004) The prevalence of metabolic syndrome in patients with schizoaffective disorder – bipolar subtype. Bipolar Disorders 6, 314–318 CrossRefGoogle ScholarPubMed
Benetou, V, Bamia, C, Trichopoulos, D, Mountokalalakis, T, Psaltopoulou, T & Trichopoulou, A (2004) The association of body mass index and waist circumference with blood pressure depends on age and gender: A study of 10 928 non-smoking adults in the Greek EPIC cohort. European Journal of Epidemiology 19, 803–809 CrossRefGoogle Scholar
Bjorntorp, P (1999) Neuroendocrine perturbations as a cause of insulin resistance. Diabetic Metabolism Research Reviews 15, 427–441 3.0.CO;2-C>CrossRefGoogle ScholarPubMed
Bjorntorp, P (2000) Do stress reactions cause abdominal obesity and comorbidities. Obesity Reviews 2, 73–86 Google Scholar
Bjorntorp, P & Rosmond, R (1999) Hypothalamic origin of the metabolic syndrome X. Annals of the New York Academy of Sciences 892, 297–307 Google Scholar
Bjorntorp, P & Rosmond, R (2000) Neuroendocrine abnormalities in visceral obesity. International Journal of Obesity 24, S80–S85 Google Scholar
Black, PH (2003) The inflammatory response is an integral part of the stress response: implications for atherosclerosis, insulin resistance, type II diabetes and metabolic syndrome X. Brain, Behaviour and Immunity 17, 350–364 CrossRefGoogle ScholarPubMed
Brindley, DN (1995) Role of glucocorticoids and fatty acids in the impairment of lipid-metabolism observed in the metabolic syndrome. International Journal of Obesity 19, S69–S75 Google Scholar
Brown, ES, Varghese, FP & McEwan, BS (2004) Association of depression with mental illness: does cortisol play a role. Biological Psychiatry 55, 1–9 Google Scholar
Brunner, EJ, Hemmingway, H, Walker, BR, Page, M, Clarke, P, Juneja, M et al. . (2002) Adrenocortical, autonomic and inflammatory causes of the metabolic syndrome. Circulation 106, 2659–2665 CrossRefGoogle ScholarPubMed
Brunner, EJ, Marmot, MG, Nanchahal, K, Shipley, MJ, Stansfeld, SA, Juneja, M & Alberti, KGMM (1997) Social inequality in coronary risk: central obesity and the metabolic syndrome. Evidence from the Whitehall II study. Diabetologia 40, 1341–1349 Google Scholar
Buttriss, J (2003) Metabolic syndrome: new research underway. Nutrition Bulletin 28, 381–385 CrossRefGoogle Scholar
Chen, W, Bao, W, Begum, S, Elkasabany, A & Srinivasan, SR (2000) Age-related patterns of the clustering of cardio-vascular risk variables of Syndrome X from childhood to young adulthood in a population made up of black and white subjects. The Bogalusa Heart Study. Diabetes 49, 1042–1048 Google Scholar
Cook, WW & Medley, DM (1954) Proposed hostility and parasisaic-virtue scales for the MMPI. Journal of Applied Psychology 38, 414–418 Google Scholar
Danesh, HB (1977) Anger and fear. American Journal of Psychiatry 134, 1109–1112 Google Scholar
Diamond, EL (1982) The role of anger and hostility in essential hypertension and coronary heart disease. Psychological Bulletin 92, 410–433 Google Scholar
Drapeau, V, Therrien, F, Richard, D & Tremblay, A (2003) Is visceral obesity a physiological adaptation to stress. Panminerva Medica 45, 189–195 Google ScholarPubMed
Eikelis, N, Lambert, G, Weisner, G, Kaye, D, Schlaich, M, Morris, M, Hastings, J, Socratous, F & Esler, M (2004) Extra-adipocyte leptin release in human obesity and its relation to symphathoadrenal function. American Journal of Physiology 286, E744–E752 Google Scholar
Esler, M, Rumantir, M, Wiesner, G, Kaye, D, Hastings, J & Lambert, G (2001) Sympathetic nervous system and insulin resistance: form obesity to diabetes. American Journal of Hypertension 14, S304–S309 Google Scholar
Feldman, PJ & Steptoe, A (2003) Psychosocial and socioeconomic factors associated with glycated hemoglobin in non-diabetic middle-aged men and women. Health Psychology 22, 398–405 Google Scholar
Friedman, M & Rosenman, RH (1959) Association of a specific overt behaviour pattern with increases in blood cholesterol, blood clotting time, incidence of arcus senilis and clinical coronary artery disease. Journal of the American Medical Association 169, 1286–1296 CrossRefGoogle Scholar
Frost, A, Eachus, J, Sparrow, J, Peters, TJ, Hopper, C, Davey-Smith, G & Frankel, S (2001) Vision-related quality of life impairment in an elderly population: associations with age, sex, social class and material deprivation. Eye 15, 739–744 CrossRefGoogle Scholar
Gigolini, M, Seidell, JC, Targher, G, Deslypere, JP, Ellsinger, BM, Charzewska, J, Cruz, A & Bjorntorp, P (1995) Fasting serum-insulin in relation to components of the metabolic syndrome in European healthy men – the European fat distribution study. Metabolism: Clinical and Experimental 44, 35–40 Google Scholar
Halford, JCG (2001) Pharmacology of appetite suppression: implication for the treatment of obesity. Current Drug Targets 2, 353–370 Google Scholar
Haynes, SG, Levine, S, Scotch, N, Feinleib, M & Kannel, WB (1980) The relationship of psychological factors to coronary heart disease in the Frammington Study: I. Methods and risk factors. American Journal of Epidemiology 107, 362–383 Google Scholar
Hidvegi, T, Hetyesi, K, Biro, L & Jermendy, G (2001) Education level and clustering of clinical characteristics of metabolic syndrome. Diabetes Care 24, 2013–2016 Google Scholar
Ho, SC, Chen, YM, Woo, JLF, Leung, SSF, Lam, TH & Janus, ED (2001) Association between simple anthropometric indices and cardiovascular risk factors. International Journal of Obesity 25, 1689–1697 Google Scholar
Horsten, M, Mittleman, MA, Wamala, SP, Schenck-Gustafsson, K, Orth-Gomer, K (1999) Social relations and the metabolic syndrome in middle-aged Swedish women. Journal of Cardio-Vascular Risk 6, 391–397 Google Scholar
Katzmarzyk, PT, Perusse, L, Bergeron, J, Despres, JP & Bouchard, C (2001) Stability of indicators of the metabolic syndrome from childhood and adolescence into young adulthood: the Quebec Family Study. Journal of Clinical Epidemiology 54, 190–195 CrossRefGoogle ScholarPubMed
Kiecolt-Glaser, JK, McGuire, L, Robles, TF & Glaser, R (2002) Emotions, morbidity and mortality: New perspectives. Psychoneuroimmunology 53, 83–92 Google Scholar
Kerenyi, Z, Tabac, AG, Stella, P, Bosyak, Z, Simon, K, Karadi, I & Tamas, G (2000) Association between socioeconomic factors and the metabolic syndrome in women with prior gestational diabetes mellitus. Diabetes Care 23, 1444–1446 Google Scholar
Kinder, LS, Carnethon, MR, Palaniappan, LP, King, AC & Fortmann, SP (2004) Depression and the metabolic syndrome in young adults: findings from the third national health and nutrition examination survey. Psychosomatic Medicine 66, 316–322 Google Scholar
Laaksonen, DE, Lakka, HM, Lynch, J, Lakka, TA, Niskanen, L, Rauramaa, R, Salonen, JT & Kauhanen, J (2003) Cardiorespiratory fitness and vigorous leisure-time physical activity modify the association of small size at birth with the metabolic syndrome. Diabetes Care 26, 2156–2164 Google Scholar
Laaksonen, DE, Lakka, HM, Salonen, JT, Niskanen, LK, Rauramaa, R & Lakka, TA (2002) Low levels of leisure-time physical activity and cardio-respiratory fitness predict development of the metabolic syndrome. Diabetes Care 25, 1612–1619 CrossRefGoogle Scholar
Landen, M, Baghaei, F, Rosmond, R, Holm, G, Bjorntorp, P & Eriksson, E (2004) Dystipiclemia and high waist-hip ratio in women with self reported social anxiety. Psychoneuroendocrinology 29, 1037–1046 CrossRefGoogle ScholarPubMed
Lawlor, DA, Ebrahim, S, Davey-Smith, G (2004) The metabolic syndrome and coronary heart disease in older women: findings from the British Women's Heart and Health Study. Diabetic Medicine 21, 906–913 Google Scholar
Lidfeldt, J, Nyberg, P, Nerbrand, C, Samsioe, G, Schersten, B & Agardh, CD (2003) Socio-demographic and psychosocial factors are associated with features of the metabolic syndrome. The women's health in the Lund Area (WHILA) study. Diabetes, Obesity and Metabolism 5, 106 Google Scholar
McCaffery, JM, Niaura, R, Todaro, JF, Swan, GE & Carmelli, D (2003) Depressive symptoms and metabolic risk in adult male twins enrolled in the national heart, lung and blood institute twin study. Psychosomatic Medicine 65, 409–497 Google Scholar
McElroy, SL, Kotwal, R, Malhotra, S, Nelson, EB, Keck, PE & Nemeroff, CB (2004) Are mood disorders and obesity related? A review for the mental health professional. Journal of Clinical Psychiatry 65, 634–651 Google Scholar
Martins, IS & Marinho, SP (2003) The potential of central obesity anthropometric indicators as diagnostic tools. Revista de Saude Publica 37, 760–767 Google Scholar
Meigs, JB, D'Agostino, RB, Wilson, PW & Cupples, LA (1997) Risk variable clustering in the insulin resistance syndrome. Diabetes 46, 1594–1601 Google Scholar
Muldoon, MF, Mackey, RH, Williams, KV, Korytkowski, MT, Flory, JD & Manuck, SB (2004) Low central nervous system serotonergic responsivity is associated with the metabolic syndrome and physical inactivity. Journal of Clinical Endocrinology and Metabolism 89, 266–271 Google Scholar
Niaura, R (2002) Heart disease; high hostility may be more predictive than other factors. Heart Disease Weekly 29 December issue 7Google Scholar
Niaura, R, Banks, SM, Ward, KD, Stonay, CM, Spiro, A, Aldwin, CM, Landsberg, L & Weiss, ST (2000) Psychosomatic Medicine 62, 7–16 CrossRefGoogle Scholar
Nonogaki, K (2000) New insights into sympathetic regulation of glucose and fat metabolism. Diabetologia 43, 533–549 Google Scholar
Okosun, S, Cooper, RS, Rotimi, CN, Osotimehin, B & Forrester, T (1998) Association of waist circumference with risk of hypertension and type 2 diabetes in Nigerians, Jamaicans and African Americans. Diabetes Care 21, 1836–1839 CrossRefGoogle ScholarPubMed
Okosun, S, Liao, YL, Rotimi, CN, Prewitt, TE & Cooper, S (2000) Abdominal adiposity and clustering of multiple metabolic syndrome in white, black and Hispanic Americans. Annals of Epidemiology 10, 263–270 Google Scholar
Onat, A, Avci, GS, Barlan, MM, Uyarel, H, Uzunlar, B & Sansoy, V (2004) Measures of abdominal obesity assessed for visceral adiposity and relation to coronary risk. International Journal of Obesity and Related Metabolic Diseases 28, 1018–1025 Google Scholar
Oppert, JM, Lahlou, N, Laferrere, B, Roger, M, Basdevant, A & GuyGrand, B (1997) Plasma leptin and acute serotonergic stimulation of the corticotropic axis in women who are normal weight or obese. Obesity Research 5, 410–416 CrossRefGoogle ScholarPubMed
Paffenbarger, RS, Wing, AL & Hyde, RT (1978) Physical activity as an index of heart attack risk in college alumni. American Journal of Epidemiology 108, 161–175 Google Scholar
Plutchik, R (1980) Emotion: A Psychoevolutionary Synthesis New York Harper & RowGoogle Scholar
Puttonen, S, Keltikangas-Jarvinen, L, Ravaja, N & Viikari, J (2003) Affects and autonomic cardiac reactivity during experimentally-induced stress as related to precursors of insulin resistance syndrome. International Journal of Behavioural Medicine 10, 106–124 Google Scholar
Raikkonen, K, Keltikangas-Jarvinen, L, Ladlercreutz, H & Hautanen, A (1996) Psychosocial stress and the insulin resistance syndrome. Metabolism 45, 1533–1538 Google Scholar
Raikkonen, K, Matthews, KA & Kuller, LH (1999a) Anthropometric and psychosocial determinants of visceral obesity in healthy postmenopausal women. International Journal of Obesity 23, 775–782 Google Scholar
Raikkonen, K, Matthews, KA & Kuller, LH (2002) The relationship between psychological risk attributes and the metabolic syndrome in healthy women: antecedent or consequence. Metabolism 51, 1573–1577 Google ScholarPubMed
Raikkonen, K, Matthews, KA, Kuller, LH, Reiber, C & Bunker, CH (1999b) Anger, hostility and visceral adipose tissue in healthy post-menopausal women. Metabolism 48, 1146–1151 Google Scholar
Raikkonen, K, Matthews, KA & Salomon, K (2003) Hostility predicts metabolic syndrome risk factors in children and adolescents. Health Psychology 22, 279–286 CrossRefGoogle ScholarPubMed
Ravaja, N, Keltikangas-Jarvinen, L & Viikari, J (1996) Life changes, locus of control and metabolic syndrome precursors in adolescents and young adults: a three-year follow-up. Social Science and Medicine 43, 51–61 CrossRefGoogle Scholar
Rennie, KL, McCarthy, N, Yazdgerdi, S, Marmot, M & Brunner, E (2003) Association of metabolic syndrome with both vigorous and moderate physical activity. International Journal of Epidemiology 32, 600 Google Scholar
Riserus, U, Arnlov, J, Brismar, K, Zethelius, B, Berglund, L & Vessby, B (2004) Sagittal abdominal diameter is a strong anthropometric marker of insulin resistance and hyperproinsulinemia in obese men. Diabetes Care 27, 2041–2046 Google Scholar
Rosmond, R, Holm, G & Bjorntorp, P (2000) Food-induced cortisol secretion in relation to anthropometric, metabolic and haemodynamic variables in men. International Journal of Obesity 24, 416–422 CrossRefGoogle ScholarPubMed
Roth, JL, Mobarhan, S & Clohisy, M (2002) The metabolic syndrome: where are we where do we go. Nutrition Reviews 60, 335–337 Google Scholar
Roy, S, Rink, C, Khanna, S, Phillips, C, Bagchi, D, Bagchi, M & Sen, CK (2004) Bodyweight and abdominal fat gene expression profile in response to a novel hydroxycitric acid-based dietary supplement. Gene Expression 11, 251–262 CrossRefGoogle Scholar
Sargent, PA, Sharpley, AL, Williams, C, Goodall, EM & Cowen, PJ (1997) 5-HT2C receptor activation decreases appetite and body weight in obese subjects. Psychopharmacology 133, 309–312 Google Scholar
Seematter, G, Binnert, C, Martin, JL & Tappy, L (2004) Relationship between stress, inflammation and metabolism. Current Opinion in Clinical Nutrition and Metabolic Care 7, 169–173 Google Scholar
Siani, A, Cappuccio, FP, Barba, G, Trevisan, M, Farinaro, E, Iacone, R, Russo, O, Russo, P, Mancini, M & Strazzullo, P (2002) The relationship of waist circumference to blood pressure: the Olivetti Heart Study. American Journal of Hypertension 15, 780–786 Google Scholar
Snijder, MB, Zimmet, PZ, Visser, M, Dekker, JM, Seidell, JC & Shaw, JE (2004) Independent and opposite associations of waist and hip circumferences with diabetes, hypertension and dyslipidemia: the AusDiab Study. International Journal of Obesity 28, 402–409 Google Scholar
Spielberger, CD (1983) Manual for the State-Trait Anger Scale (STAS) Palo Alto, CA Consulting Psychologist's PressGoogle Scholar
Steptoe, A & Marmot, M (2003) Burden of psychological adversity and vulnerability in middle age: associations with biobehavioural risk factors and quality of life. Psychosomatic Medicine 65, 1029–1037 Google Scholar
Vanhala, MJ, Vanhala, PT, Keinanen-Kiukaanniemi, SM, Kumpusalo, EA & Takala, JK (1999) Relative weight gain and obesity as a child predict metabolic syndrome as an adult. International Journal of Obesity 23, 656–659 Google Scholar
Vieta, E (2004) Olanzapine in bipolar disorder. Expert Opinion on Pharmacotherapy 5, 1613–1619 Google Scholar
Vitaliano, PP, Scanlan, JM, Zhang, JP, Savage, MV, Hirsch, IB & Siegler, IC (2002) Heart disease; role of chronic stress clarified Heart Disease Weekly 16 June issue 16 Google Scholar
Waldstein, SR, Burns, HO, Toth, MJ & Poehlman, ET (1999) Cardiovascular reactivity and central adiposy in older African Americans. Health Psychology 18, 221–228 Google Scholar
Wallerius, S, Rosmond, R, Ljung, T, Holm, G & Bjorntorp, P (2003) Rise in morning saliva cortisol is associated with abdominal obesity in men: a preliminary report. Journal of Endocrinological Investigation 26, 616–619 Google Scholar
Wamala, SP, Lynch, J, Horsten, M, Mittleman, MA, Schenck-Gustafsson, K, Orth-Gomer, K (1999) Education and the metabolic syndrome in women. Diabetes Care 22, 1999–2003 Google Scholar
Ward, AMV, Syddall, HE, Wood, PJ, Dennison, EM & Phillips, DIW (2004) Central hypothalamic-pituitary-adrenal activity and the metabolic syndrome: studies using the corticotrophin-releasing hormone test. Metabolism: Clinical and Experimental 53, 720–726 Google Scholar
Weber-Hamann, B, Hentschel, F, Kniest, A, Deuschle, M, Colla, M, Lederbogen, F & Heuser, I (2002) Hypercolesterolemic depression is associated with increased intra-abdominal fat. Psychosomatic Medicine 54, 274–277 Google Scholar
Wellman, PJ, Jones, SL & Miller, DK (2003) Effects of preexposure to dexfenfluramine, phentermine, dexfenfluramine-phentennine or fluoxetine on sibutramine-induced hypophagia in the adult rat. Pharmacology Biochemistry and Behavior 75, 103–114 Google Scholar
Woodall, KL & Matthews, KA (1993) Change in and stability of hostile characteristics: results form a 4-year longitudinal study of children. Journal of Personality and Social Psychology 64, 491–499 Google Scholar
Zimmermann, U, Kraus, T, Himmerich, H, Schuld, A & Pollmacher, T (2003) Epidemiology, implications and mechanisms underlying drug-induced weight gain in psychiatric patients. Journal of Psychiatric Research 37, 193–220 CrossRefGoogle ScholarPubMed
Yarbrough, DE, Barrett-Connor, E, Kritz-Silverstein, D & Wingard, DL (1998) Birth weight, adult weight and girth as predictors of the metabolic syndrome in postmenopausal women. Diabetes Care 21, 1652–1659 Google Scholar