Hostname: page-component-cd9895bd7-gbm5v Total loading time: 0 Render date: 2024-12-26T08:52:53.313Z Has data issue: false hasContentIssue false
  • English
  • Français

Respiration uncoupling and metabolism in the control of energy expenditure

Published online by Cambridge University Press:  07 March 2007

Daniel Ricquier
Daniel Ricquier
Affiliation:
Centre National de la Recherche Scientifique Unit 9078; Faculty of Medicine Necker-Enfants Malades, Paris, France
Rights & Permissions [Opens in a new window]

Abstract

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'

Keywords

Respiration uncouplingEnergy expenditureUncoupling protein 1Brown adipose tissue
Type
Symposium on ‘Biology of obesity’
Information
Proceedings of the Nutrition Society , Volume 64 , Issue 1 , February 2005 , pp. 47 - 52
Copyright
Copyright © The Nutrition Society 2005

References

Alves-Guerra, MC, Rousset, S, Pecqueur, C, Mallat, Z, Blanc, J, Tedgui, A, Bouillaud, F, Cassard-Doulcier, AM, Ricquier, D, Miroux, B (2003) Bone marrow transplantation reveals the in vivo expression of the mitochondrial uncoupling protein 2 in immune and non immune cells during inflammation Journal of Biological Chemistry 278 42307–42312 CrossRefGoogle ScholarPubMed
Bechmann, I, Diano, S, Warden, CH, Bartfai, T, Nitsch, R, Horvath, TL (2002) Brain mitochondrial uncoupling protein 2 (UCP2): a protective stress signal in neuronal injury Biochemical Pharmacology 64 363–367 CrossRefGoogle ScholarPubMed
Blanc, J, Alves-Guerra, MC, Esposito, B, Rousset, S, Gourdy, P, Ricquier, D, Tedgui, A, Miroux, B, Mallat, Z (2003) Protective role of uncoupling protein 2 in atherosclerosis Circulation 107 388–390 CrossRefGoogle ScholarPubMed
Bouchard, C, Perusse, L, Chagnon, YC, Warden, C, Ricquier, D (1997) Linkage between markers in the vicinity of the uncoupling protein 2 gene and resting metabolic rate in humans Human Molecular Genetics 11 1887–1889 Google Scholar
Boss, O, Hagen, T, Lowell, BB (2001) Uncoupling proteins 2 and 3: potential regulators of mitochondrial energy metabolism Diabetes 49 143–156 Google Scholar
Cadenas, S, Echtay, KS, Harper, JA, Jekabsons, MB, Buckingham, JA, Grau, E, Abuin, A, Chapman, H, Clapham, JC, Brand, MD (2002) The basal proton conductance of skeletal muscle mitochondria from transgenic mice overexpressing or lacking uncoupling protein-3 Journal of Biological Chemistry 277 2773–2778 Google Scholar
Cannon, B, Nedergaard, J (2004) Brown adipose tissue: function and physiological significance Physiological Reviews 84 277–359 CrossRefGoogle ScholarPubMed
Chan, CB, Saleh, MC, Koshkin, V, Wheeler, MB (2004) Uncoupling protein 2 and islet function Diabetes 53 S136–S142 CrossRefGoogle ScholarPubMed
Clapham, C, Arch, JR, Chapman, H, Haynes, A, Lister, C, Moore, GB, et, al (2000) Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean Nature 406 415–418 Google Scholar
Clavel, S, Paradis, E, Ricquier, D, Richard, D (2003) Kainic acid upregulated uncoupling protein-2 mRNA expression in the mouse brain Neuroreport 14 2015–2017 Google Scholar
Collins, P, Bing, C, McGulloch, P, Williams, G (2002) Muscle UCP-3 mRNA levels are elevated in weight loss associated with gastrointestinal adenocarcinoma in humans British Journal of Cancer 86 372–375 Google Scholar
Couplan, E, Gelly, C, Goubern, M, Fleury, C, Quesson, B, Silberberg, M, et, al (2002a) High level of uncoupling protein 1 expression in muscle of transgenic mice selectively affects muscles at rest and decreases their IIb fiber content Journal of Biological Chemistry 277 43079–43088 CrossRefGoogle ScholarPubMed
Couplan, E, Gonzalez-Barroso, MM, Alves-Guerra, MC, Ricquier, D, Goubern, M, Bouillaud, F (2002b) No evidence for a basal, retinoic or superoxide-induced uncoupling activity of the UCP2 present in spleen or lung mitochondria Journal of Biological Chemistry 277 26268–26275 CrossRefGoogle ScholarPubMed
de Bilbao, F, Arsenijevic, D, Vallet, P, Hjelle, OP, Ottersen, OP, Bouras, C et al. (2004) Resistance to cerebral ischemic injury in UCP2 knockout mice: evidence for a role of UCP2 as a regulator of mitochondrial glutathione levels Journal of Neurochemistry 89 1283–1293 Google Scholar
de Lange, P, Lanni, A, Beneduce, L, Moreno, M, Lombardi, A, Silvestri, E, Goglia, F (2001) Uncoupling protein-3 is a molecular determinant for the regulation of resting metabolic rate by thyroid hormone Endocrinology 142 3414–3420 CrossRefGoogle ScholarPubMed
Diehl, AM, Hoek, JB (1999) Mitochondrial uncoupling: Role of uncoupling protein anion carriers and relationship to thermogenesis and weight control ‘The benefits of losing control’ Journal of Bioenergetics and Biomembranes 31 493–505 Google Scholar
Dulloo, AG, Samec, S (2001) Uncoupling proteins: their roles in adaptive thermogenesis and substrate metabolism reconsidered British Journal of Nutrition 86 123–139 Google Scholar
Echtay, KS, Esteves, TC, Pakay, JL, Jekabsons, MB, Lambert, AJ, Portero-Otin, M, Pamplona, R, Vidal-Puig, AJ, Wang, S, Roebuck, SJ, Brand, MD (2003) A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling EMBO Journal 22 4103–4110 Google Scholar
Echtay, KS, Roussel, D, St-Pierre, J, Jekabsons, MB, Cadenas, S, Stuart, JA, Harper, JA, Roebuck, SJ, Morrison, A, Pickering, S, Clapham, JC, Brand, MD (2002) Superoxide activates mitochondrial uncoupling proteins Nature 415 96–99 Google Scholar
Garcia-Martinez, C, Sibille, B, Solanes, G, Darimont, C, Mace, K, Villaroya, F, Gomez-Foix, AM (2001) Overexpression of UCP3 in cultured human muscle lowers mitochondrial membrane potential, raises ATP/ADP ratio, and favors fatty acid vs. glucose oxidation FASEB Journal 11 2033–2035 Google Scholar
Garlid, KD, Jaburek, M (1998) The mechanism of proton transport mediated by mitochondrial uncoupling proteins FEBS Letters 438 10–14 Google Scholar
Goglia, F, Skulachev, VP (2003) A function for novel uncoupling proteins: antioxidant defense of mitochondrial matrix by translocating fatty acid peroxides from the inner to the outer membrane leaflet FASEB Journal 17 1585–1591 Google Scholar
Hesselink, MKC, Greenhaff, PL, Constantin-Teodosiu, D, Hultma, E, Saris, WHM, Nieuwlaat, R, Schaart, G, Kornips, E, Schrauwein, P (2003) Increased uncoupling protein 3 content does not affect mitochondrial function in human skeletal muscle in vivo Journal of Clinical Investigation 111 479–486 Google Scholar
Hu, X, Murphy, F, Karwautz, A, Li, T, Giotakis, O, Treasure, J, Collier, DA (2002) Analysis of microsatellite markers at the UCP2/UCP3 locus on chromosome 11q13 in anorexia nervosa Molecular Psychiatry 7 814 Google Scholar
Ibrahim, SM, Mix, E, Böttcher, T, Koczan, D, Gold, R, Rolfs, A, Thiesen, HJ (2000) Gene expression profiling of the nervous system in murine experimental autoimmune encephalomyelitis Brain 124 1927–1938 CrossRefGoogle Scholar
Kizaki, T, Suzuki, K, Hitomi, Y, Taniguchi, N, Saitoh, D, Watanabe, K, Onoe, K, Day, NK, Good, RA, Ohno, H (2002) Uncoupling protein 2 plays an important role in nitric oxide production of lipopolysaccharide-stimulated macrophages Proceedings of the National Academy of Sciences USA 99 9392–9397 Google Scholar
Klingenberg, M, Echtay, KS (2001) Uncoupling proteins: the issues from a biochemist point of view Biochimica et Biophysica Acta 1504 128–143 CrossRefGoogle ScholarPubMed
Kopecky, J, Clarke, G, Enerback, S, Spielgelman, B, Kozak, LP (1995) Expression of the mitochondrial uncoupling protein gene from the ap2 gene promoter prevents genetic obesity Journal of Clinical Investigation 96 2914–2923 Google Scholar
Kozak, LP, Harper, ME (2000) Mitochondrial uncoupling proteins in energy expenditure Annual Review of Nutrition 20 339–363 Google Scholar
Krauss, S, Zhang, CY, Lowell, BB (2002) A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2 Proceedings of the National Academy of Sciences USA 99 118–122 CrossRefGoogle ScholarPubMed
Lanouette, CM, Giacobino, JP, Perusse, L, Lacaille, M, Yvon, C, Chagnon, M, Kuhne, F, Bouchard, C, Muzzin, P, Chagnon, YC (2001) Association between uncoupling protein 3 gene and obesity-related phenotypes in the Quebec Family Study Molecular Medicine 7 433–441 Google Scholar
Ledesma, A, de Lacoba, MG, Rial, E (2002) The mitochondrial uncoupling proteins Genome Biology 3 3015.1 – 3015.9 Google Scholar
Li, B, Nolte, LA, Ju, JS, Han, DH, Coleman, T, Holloszy, JO, Semenkovich, CF (2000) Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice Nature Medicine 6 1115–1120 Google Scholar
Luft, R (1992) Luft's disease revisited. Severe hypermetabolism of nonthyroid origin with a defect in the maintenance of mitochondrial respiratory control Mount Sinai Journal of Medicine 59 140–145 Google Scholar
Mattiasson, G, Shamloo, M, Gido, G, Mathi, K, Tomasevic, G, Yi, S, Warden, CH, Castilho, RF, Melcher, T, Gonzalez-Zulueta, M, Nikolich, K, Wieloch, T (2003) Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma Nature Medicine 9 1062–1068 Google Scholar
Mills, EM, Banks, ML, Sprague, JE, Finkel, T (2003) Pharmacology: uncoupling the agony from ecstasy Nature 426 403–404 CrossRefGoogle ScholarPubMed
Mills, EM, Xu, D, Fergusson, MM, Combs, CA, Xu, Y, Finkel, T (2002) Regulation of cellular oncosis by uncoupling protein 2 Journal of Biochemical Chemistry 277 27385–27392 Google Scholar
Nègre-Salvayre, A, Hirtz, C, Carrera, G, Cazenave, R, Troly, M, Salvayre, R, Penicaud, L, Casteilla, L (1997) A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generation FASEB Journal 11 809–815 CrossRefGoogle ScholarPubMed
Nicholls, DG, Ferguson, SL (2002) Bioenergetics Amsterdam Academic PressGoogle Scholar
Nicholls, DG, Locke, R (1984) Brown fat thermogenesis Physiological Reviews 64 1–64 Google Scholar
Paradis, E, Clavel, S, Bouillaud, F, Ricquier, D, Richard, D (2003) Uncoupling protein-2: a novel player in neuroprotection Trends in Molecular Medicine 9 522–525 Google Scholar
Pecqueur, C, Alves-Guerra, MC, Gelly, C, Levi-Meyrueis, C, Couplan, E, Collins, S, Ricquier, D, Bouillaud, F, Miroux, B (2001) Uncoupling protein 2, in vivo distribution, induction upon oxidative stress, and evidence for translational regulation Journal of Biological Chemistry 276 8705–8712 CrossRefGoogle ScholarPubMed
Ricquier, D, Bouillaud, F (2000) The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP & AtUCP Biochemical Journal 345 161–179 Google Scholar
Ricquier, D, Kozak, LK (2003) Uncoupling proteins Handbook of Obesity 539 – 558 Bray GA Bouchard C New York Marcel Dekker IncGoogle Scholar
Ryu, JW, Hong, KH, Maeng, JH, Kim, JB, Ko, J, Park, JY, Lee, KU, Hong, MK, Park, SW, Kim, YH, Han, KH (2004) Overexpression of uncoupling protein 2 in THP1 monocytes inhibits beta2 integrin-mediated firm adhesion and transendothelial migration Arteriosclerosis, Thrombosis and Vascular Biology 24 864–870 Google Scholar
Sullivan, PG, Dube, C, Dorenbos, K, Steward, O, Baram, TZ (2003) Mitochondrial uncoupling protein-2 protects the immature brain from excitotoxic neuronal death Annals of Neurology 53 711–717 Google Scholar
Teshima, Y, Akao, M, Jones, SP, Marban, E (2003) Uncoupling protein-2 overexpression inhibits mitochondrial death pathway in cardiomyocytes Circulation Research 93 192–200 Google Scholar
Tiraby, C, Langin, D (2003) Conversion from white to brown adipocytes: a strategy for the control of fat mass Trends in Endocrinology and Metabolism 14 439–441 Google Scholar
Tiraby, C, Tavernier, G, Lefort, C, Larrouy, D, Bouillaud, F, Ricquier, D, Langin, D (2003) Acquirement of brown fat cell features by human white adipocytes Journal of Biological Chemistry 278 33370–33376 Google Scholar
Voehringer, DW, Hirschberg, DL, Xiao, J, Lu, Q, Roederer, M, Lock, CB, Herzenberg, LA, Steinman, L, Herzenberg, LA (2000) Gene microarray identification of redox and mitochondrial elements that control resistance or sensitivity to apoptosis Proceedings of the National Academy of Sciences USA 97 2680–2685 Google Scholar