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The Sir David Cuthbertson Medal Lecture 1992

The immunological and metabolic effects of L-arginine in human cancer

Published online by Cambridge University Press:  28 February 2007

Kenneth G. M. Park
Kenneth G. M. Park
Affiliation:
The Department of Surgery, Aberdeen University, Foresterhill, Aberdeen AB9 2ZD and The Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
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Abstract

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Type
Meeting Report
Information
Proceedings of the Nutrition Society , Volume 52 , Issue 3 , October 1993 , pp. 387 - 401
Copyright
Copyright © The Nutrition Society 1993

References

REFERENCES

Baccino, F. M., Tessitore, L. & Bonelli, G. (1984). Control of protein degradation and growth in normal and neoplastic cells. Toxicology and Pathology 12, 281–287.CrossRefGoogle ScholarPubMed
Barbul, A. (1986). Arginine biochemistry, physiology and therapeutic implications. Journal of Parenteral and Enteral Nutrition 10, 227–238.CrossRefGoogle ScholarPubMed
Barbul, A., Rettura, G. & Levenson, S. M. (1977). Arginine: thymotropic and wound promoting agent. Surgical Forum 28, 101–103.Google ScholarPubMed
Barbul, A., Sisto, D. A., Wasserkrug, H. L. & Efron, G. (1981). Arginine stimulates lymphocyte immune response in healthy human beings. Surgery 90, 244–251.Google ScholarPubMed
Barbul, A., Wasserkrug, H. L. & Seifter, E. (1980). Immunostimulatory effects of arginine in normal and injured rats. Journal of Surgical Research 29, 228–235.CrossRefGoogle ScholarPubMed
Brittenden, J., Park, K. G. M., Hayes, P. D., Ashby, J. A., Heys, S. D. & Eremin, O. (1992). The effect of arginine in cancer patients and healthy volunteers. British Journal of Surgery 79, 442.Google Scholar
Brittenden, J., Park, K. G. M., Heys, S. D., Ross, C., Ashby, J. A., Ah-See, A. K. & Eremin, O. (1993). L-Arginine stimulates host defences in patients with breast cancer. Surgery (In the Press).Google Scholar
Conti, S., West, J. P. & Fitzpatrick, H. F. (1977). Mortality and morbidity after esophago gastrectomy for cancer of the esophagus and cardia. American Surgery 43, 92–96.Google Scholar
Daly, J. M., Reynolds, J. V., Sigal, R. K., Shou, J. & Liberman, M. D. (1990). Effect of dietary protein and amino acids on immune function. Critical Care Medicine 18, S86–S93.CrossRefGoogle ScholarPubMed
Detsky, A. S., Baker, J. P., O'Rourke, K., Johnston, N., Whitwell, J., Mendelson, R. A. & Jeejeebhoy, K. N. (1987). Predicting nutrition associated complications for patients undergoing gastrointestinal surgery. Journal of Parenteral and Enteral Nutrition 11, 440–446.CrossRefGoogle ScholarPubMed
Douglas, R. G. & Shaw, J. H. (1990). Metabolic effects of cancer. British Journal of Surgery 77, 246–254.CrossRefGoogle ScholarPubMed
Gerdes, J., Lemke, H., Baisch, H., Wacker, H. H., Schwab, U. & Stein, H. (1984). Cell cycle analysis of a cell proliferation associated human nuclear antigen defined by the monoclonal antibody Ki-67. Journal of Immunology 133, 1710–1716.CrossRefGoogle ScholarPubMed
Hall, P. A. & Levison, D. A. (1990). Review: assessment of cell proliferation in histological material. Journal of Clinical Pathology 43, 184–192.CrossRefGoogle ScholarPubMed
Heatly, R. V., Williams, R. H. P. & Lewis, M. H. (1979). Preoperative intravenous feeding: a controlled trial. Postgraduate Medical Journal 55, 541–545.CrossRefGoogle Scholar
Heys, S. D., Park, K. G. M., McNurlan, M. A., Milne, E., Eremin, O., Wernerman, J., Keenan, R. A. & Garlick, P. J. (1991). Stimulation of protein synthesis in human tumours by parenteral nutrition: evidence for modulation of tumour growth. British Journal of Surgery 78, 483–487.CrossRefGoogle ScholarPubMed
Holter, A. R. & Fisher, J. E. (1977). The effects of perioperative hyperalimentation on complications in patients with carcinoma and weight loss. Journal of Surgical Research 23, 31–34.CrossRefGoogle ScholarPubMed
Jensen, S. (1985). Clinical effects of enteral and parenteral nutrition preceding surgery. Medical Oncology and Tumour Pharmacotherapy 2, 225–229.CrossRefGoogle Scholar
Kamel, O. W., Franklin, W. A., Ringus, J. C. & Meyer, J. S. (1989). Thymidine labelling and Ki-67 growth fraction in lesions of the breast. American Journal of Pathology 143, 107–113.Google Scholar
King, W. W. K., Boelhouwer, R. U. & Kingsnorth, A. N. (1985). Total parenteral nutrition with and without fat as substrate for growth of rats and transplanted hepatocarcinoma. Journal of Parenteral and Enteral Nutrition 9, 422–427.CrossRefGoogle ScholarPubMed
Kuppner, M., Wilkinson, S., Casson, E. & Eremin, O. (1987). In vitro generation of tumour-specific lymphocyte reactivity to colonic carcinoma cells comparison with normal colonic mucosa cells. Cancer Immunology and lmmunotherapy 25, 209–214.CrossRefGoogle ScholarPubMed
Lockwood, T. D., Minassian, I. A. & Roux, L. (1982). Protein turnover and proliferation turnover kinetics associated with elevation of 3T3-cell acid protease activity and cessation of net protein gain. Biochemical Journal 206, 239–249.CrossRefGoogle ScholarPubMed
McNurlan, M. A. & Clemens, M. J. (1986). Inhibition of cell proliferation by interferons. Biochemical Journal 237, 871–876.CrossRefGoogle ScholarPubMed
McNurlan, M. A., Tomkins, A. M. & Garlick, P. J. (1979). The effect of starvation on the rate of protein synthesis in rat liver and small intestine. Biochemical Journal 178, 373–379.CrossRefGoogle ScholarPubMed
Moghissi, K., Hornshaw, J., Teasdale, P. R. & Dawes, E. A. (1977). Parenteral nutrition in carcinoma of the oesophagus treated by sugar: nitrogen balance and clinical studies. British Journal of Surgery 64, 125–128.CrossRefGoogle Scholar
Muller, J. M., Brenner, U., Dienst, C. & Pichlmaier, H. (1982). Preoperative parenteral feeding in patients with gastrointestinal carcinoma. Lancet i, 68–71.CrossRefGoogle Scholar
Muller, J. M., Keller, H. W., Brenner, U., Walter, M. & Holzmuller, W. (1986). Indications and effects of preoperative parenteral nutrition. World Journal of Surgery 10, 53–63.CrossRefGoogle ScholarPubMed
Nixon, D. W., Lawson, D. H., Kutner, M., Ansley, J., Scharz, M., Heymsfield, S., Chawla, R., Cartwright, T. H. & Rudman, D. (1981). Hyperalimentation of the cancer patient with protein calorie undernutrition. Cancer Research 41, 2038–2045.Google ScholarPubMed
Park, K. G. M., Heys, S. D., Blessing, K., Kelly, P., McNurlan, M. A., Eremin, O. & Garlick, P. J. (1992). Stimulation of human breast cancers by dietary L-arginine. Clinical Science 82, 413–417.CrossRefGoogle ScholarPubMed
Popp, M. B., Wagner, S. C. & Brito, O. J. (1983). Host and tumour responses to increasing levels of nutritional support. Surgery 94, 300–308.Google ScholarPubMed
Pryme, I. F. (1977). The failure of growth of a mouse myeloma during the course of administration of L-arginine hydrochloride. Cancer Letters 1, 177–182.CrossRefGoogle Scholar
Reynolds, J. V., Daly, J. M., Zhang, S., Evantash, E., Shou, J., Sigal, R. & Ziegler, M. M. (1988 a). Immunomodulatory mechanisms of arginine. Surgery 104, 142–151.Google ScholarPubMed
Reynolds, J. V., Thom, A. K., Zhang, S. M., Ziegler, M. M., Naji, A. & Daly, J. M. (1988 b). Arginine protein malnutrition and cancer. Journal of Surgical Research 45, 513–522.CrossRefGoogle ScholarPubMed
Sako, K., Lore, J. M., Kaufman, S., Razack, M. S., Bakamijiam, V. & Reese, P. (1981). Parenteral hyperalimentation in surgical patients with head and neck cancer: a randomized study. Journal of Surgical Oncology 16, 391–402.CrossRefGoogle ScholarPubMed
Siato, H., Trocki, O., Wang, S., Gonce, S. J., Joffe, S. N. & Alexander, J. W. (1987). Metabolic and immune effects of dietary arginine supplementation after burn. Archives of Surgery 122, 784–789.CrossRefGoogle Scholar
Silverberg, S. G. (1976). Reproducibility of the mitosis count in the histologic diagnosis of smooth muscle tumours of the uterus. Human Pathology 7, 451–454.CrossRefGoogle ScholarPubMed
Silvestrini, R., Costa, A., Vereroni, S., Del Bino, G. & Perici, P. (1988). Comparative analysis of different approaches to investigate cell kinetics. Cell Tissue Research 21, 123–131.Google ScholarPubMed
Studley, H. O. (1936). Percentage of weight loss a basic indicator of surgical risk. Journal of the American Medical Association 106, 458–460.CrossRefGoogle Scholar
Tachibana, K., Mukai, K., Hiraoka, I., Moriguchi, S., Takama, S. & Kishino, Y. (1985). Evaluation of the effect of arginine enriched amino acid solution on tumour growth. Journal of Parenteral and Enteral Nutrition 9, 428–434.CrossRefGoogle Scholar
Thompson, B. R., Julian, T. B. & Stremple, J. F. (1981). Preoperative total parenteral nutrition in patients with gastrointestinal cancer. Journal of Surgical Research 30, 497–500.CrossRefGoogle ScholarPubMed
Torosian, M. H., Tsou, K. C. & Daly, J. M. (1984). Alteration of tumour cell kinetics by pulse total parenteral nutrition: potential therapeutic implications. Cancer 53, 1409–1415.3.0.CO;2-8>CrossRefGoogle ScholarPubMed
Trinchieri, G. (1989). Biology of natural killer cells. Advances in Immunology 47, 187–376.CrossRefGoogle ScholarPubMed
Veterans Affairs Total Parenteral Nutrition Cooperative Study Group (1991). Perioperative total parenteral nutrition in surgical patients. New England Journal of Medicine 325, 525–532.CrossRefGoogle Scholar
Von Meyenfeldt, M. F., Fredrix, E. W. H. M., Van der Aalst, A. C. M. J. & Soeters, P. B. (1988). The aetiology and management of weight loss in cancer patients. Bailliere's Clinical Gastroenterology 2, 869–885.CrossRefGoogle ScholarPubMed
Wan, J. M. F., Haw, M. P. & Blackburn, G. L. (1989). Nutrition, immune function and inflammation: an overview. Proceedings of the Nutrition Society 48, 315–335.CrossRefGoogle ScholarPubMed
Windsor, J. A. & Hill, G. L. (1988). Weight loss with physiological impairment. An indicator of surgical risk. Annals of Surgery 207, 290–296.CrossRefGoogle ScholarPubMed