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Influnce of the beta-adrenergic agonist clenbuterol on plasma catecholamines and lymphocyte beta-receptors

Published online by Cambridge University Press:  28 April 2020

B. Bondy ,
M. Ackenheil ,
G. Laakmann  and
H.T. Munz
B. Bondy
Affiliation:
Psychiatric Hospital of University of Munich, Nuβbaumstraβe 7, 8000 München 2, FRG
M. Ackenheil
Affiliation:
Psychiatric Hospital of University of Munich, Nuβbaumstraβe 7, 8000 München 2, FRG
G. Laakmann
Affiliation:
Psychiatric Hospital of University of Munich, Nuβbaumstraβe 7, 8000 München 2, FRG
H.T. Munz
Affiliation:
Psychiatric Hospital of University of Munich, Nuβbaumstraβe 7, 8000 München 2, FRG
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Summary

The influence of subchronic application of the β-adrenergic agonist clenbuterol on plasma norepinephrine (NE), epinephrine (E) and β-receptors on lymphocytes was investigated in 8 male, healthy volunteers. Treatment with clenbuterol (0.04 mg/day) for 6 days induced significant reduction of β-receptor specific binding in 7 of the 8 subjects with a mean decrease of 40% (p < 0.01) with no changes in affinity. Concomitantly an increase in the plasma NE concentration was observed (mean 50%, p < 0.01), but no significant overall alteration of E concentration. Our results suggest that β-adrenergic agonists exercise a similar effect on the peripheral adrenergic system and on the adrenergic system in the brain.

Résumé

Résumé

L’influence d’administrations subchroniques d’un agoniste bêta-adrénergique, le clenbutérol, sur les taux de noradrénaline (NE), d’adrénaline (E) plasmatiques et sur les bêta-récepteurs des lymphocytes a été etudiée chez 8 volontaires sains (hommes). Les catécholamines plasmatiques étaient déterminées par chromatographie liquide à haute pression couplée à un détecteur électro-chimique. Le ligand des bêta-récepteurs lymphocytaires était le bêta-bloquant 125-iodo-cyanopindolol (concentrations étagées de 3.4 à 150 pM). La liaison non spécifique était déterminée par 0.1 μM de propanolol. Le traitement par le clenbutérol(0.04 mg/jour) pendant 6 jours a induit une réduction significative de la liaison spécifique des bêta-récepteurs chez 7 des 8 sujets avec une diminution moyenne de 40 % (p < 0.01) sans changement d’affinité. Parallèlement, une augmentation de la concentration de noradrénaline (NE) plasmatique a été observée (moyenne 50 %, p < 0.01), mais pas de modification des concentrations d’adrénaline (E). Nos résultats suggèrent que les modifications du système noradrénergique et adrénergique induits par les agonistes bêta pourraient être similaires au niveau central et périphérique.

Keywords

Catecholaminesβ-receptorsLymphocytesClenbuterolCatécholaminesβ-récepteursLymphocytesClenbutérol
Type
Articels Courts/Brief Communications
Information
Psychiatry and Psychobiology , Volume 1 , Issue 3 , 1986 , pp. 234 - 236
Copyright
Copyright © European Psychiatric Association 1986

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