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Nouveaux phosphorothioates dérivésde la naphthylméthylimidazoline et de la naphthyléthylimidazoline : applicationen radioprotection chimique

Published online by Cambridge University Press:  16 March 2005

B. Célariès ,
C. Amourette ,
C. Lion  and
G. Rima
B. Célariès
Affiliation:
Laboratoire d’hétérochimie fondamentale et appliquée, université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex 4, France
C. Amourette
Affiliation:
Centre de recherches du Service de santé des Armées, 24 avenue des Maquis du Grésivaudan, 38702 La Tronche Cedex, France
C. Lion
Affiliation:
ITODYS, Université Paris-VII, 1 rue Guy de la Brosse, 75005 Paris, France
G. Rima
Affiliation:
Laboratoire d’hétérochimie fondamentale et appliquée, université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex 4, France
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Abstract

Dans ce travail, nous avons synthétisé des phosphorothioates dérivés de la 2‑(1‑naphthylméthyl)-2-imidazoline et de la 2-[1-(1-naphthyl)éthyl]-2-imidazoline afin d’évaluer, in vivo chez la souris, leur degré de protection contre les effets des rayonnements γ. Tous ces composés ont montré une activité radioprotectrice remarquable (facteur de réduction de dose compris entre 1,5 et 1,9) ce qui les classent parmi les plus actifs actuellement connus dans le domaine de la radioprotection chimique. Ces composés peuvent également présenter un intérêt dans le domaine des traitements de chimio- et de radio-thérapie.

Keywords

Radiation therapyRadioprotectorsPhosphorus compounds
Type
Research Article
Information
Radioprotection , Volume 40 , Issue 1 , January 2005 , pp. 57 - 71
Copyright
© EDP Sciences, 2005

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