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Putting microbiota-gut-brain research in a systemic developmental context: Focus on breast milk

Published online by Cambridge University Press:  15 July 2019

Brittany Howell Open the ORCID record for Brittany Howell [Opens in a new window]  and
Antonella Tramacere
Brittany Howell
Affiliation:
Institute of Child Development, University of Minnesota, Minneapolis, MN 55455. brhowell@umn.edu
Antonella Tramacere
Affiliation:
Department of Cultural and Linguistic Evolution, Max Planck for the Science of Human History, 07745 Jena, Germany. tramacere@shh.mpg.de
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Abstract

The microbiota-gut-brain (MGB) field holds huge potential for understanding behavioral development and informing effective early interventions for psychological health. To realize this potential, factors that shape the MGB axis in infancy (i.e., breast milk) must be integrated into a systemic framework that considers salient behavioral outcomes. This is best accomplished applying network analyses in large prospective, longitudinal investigations in humans.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 42 , 2019 , e72
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Copyright
Copyright © Cambridge University Press 2019 

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References

Arentsen, T., Qian, Y., Gkotzis, S., Femenia, T., Wang, T., Udekwu, K., Forssberg, H. & Diaz Heijtz, R. (2017) The bacterial peptidoglycan-sensing molecule Pglyrp2 modulates brain development and behavior. Molecular Psychiatry 22(2):257–66. Available at: https://doi.org/10.1038/mp.2016.182.Google Scholar
Bäckhed, F., Roswall, J., Peng, Y., Feng, Q., Jia, H., Kovatcheva-Datchary, P., Li, Y., Xia, Y., Xie, H., Zhong, H., Khan, M. T., Zhang, J., Li, J., Xiao, L., Al-Aama, J., Zhang, D., Lee, Y. S., Kotowska, D., Colding, C., Tremaroli, V., Yin, Y., Bergman, S., Xu, X., Madsen, L., Kristiansen, K., Dahlgren, J. & Wang, J. (2015) Erratum: Dynamics and stabilization of the human gut microbiome during the first year of life (Cell Host & Microbe 17, 690–703; May 13, 2015). Cell Host and Microbe 17(6):P852. Available at: https://doi.org/10.1016/j.chom.2015.05.012.Google Scholar
Carlson, A. L., Xia, K., Azcarate-Peril, M. A., Goldman, B. D., Ahn, M., Styner, M. A., Thompson, A. L., Geng, X., Gilmore, J. H. & Knickmeyer, R. C. (2018) Infant gut microbiome associated with cognitive development. Biological Psychiatry 83(2):148–59. Available at: https://doi.org/10.1016/j.biopsych.2017.06.021.Google Scholar
Christian, L. M., Galley, J. D., Hade, E. M., Schoppe-Sullivan, S., Kamp Dush, C. & Bailey, M. T. (2015) Gut microbiome composition is associated with temperament during early childhood. Brain, Behavior, and Immunity 45:118–27. Availability at: https://doi.org/10.1016/j.bbi.2014.10.018.Google Scholar
De Palma, G., Lynch, M. D. J., Lu, J., Dang, V. T., Deng, Y., Jury, J., Umeh, G., Miranda, P. M., Pigrau-Pastor, M., Sidani, S., Pinto-Sanchez, M.., Philip, V., McLean, P. G., Hagelsieb, M. G., Surette, M. G., Bergonzelli, G. E., Verdu, E. F., Britz-Mckibbin, P., Neufeld, J. D., Collins, S. M. & Bercik, P. (2017) Transplantation of fecal microbiota from patients with irritable bowel syndrome alters gut function and behavior in recipient mice. Science Translational Medicine 9(379):1–15. Available at: https://doi.org/10.1126/scitranslmed.aaf6397.Google Scholar
Diaz Heijtz, R. (2016) Fetal, neonatal, and infant microbiome: Perturbations and subsequent effects on brain development and behavior. Seminars in Fetal and Neonatal Medicine 21(6):410–17. Available at: https://doi.org/10.1016/j.siny.2016.04.012.Google Scholar
Grey, K. R., Davis, E. P., Sandman, C. A. & Glynn, L. M. (2013) Human milk cortisol is associated with infant temperament. Psychoneuroendocrinology 38(7):1178–85. Available at: https://doi.org/10.1016/j.psyneuen.2012.11.002.Google Scholar
Isaacs, E. B., Fischl, B. R., Quinn, B. T., Chong, W. K., Gadian, D. G. & Lucas, A. (2010) Impact of breast milk on intelligence quotient, brain size, and white matter development. Pediatric Research 67:357–62. Available at: https://doi.org/10.1203/PDR.0b013e3181d026da.Google Scholar
Jost, T., Lacroix, C., Braegger, C. & Chassard, C. (2015) Impact of human milk bacteria and oligosaccharides on neonatal gut microbiota establishment and gut health. Nutrition Reviews 73(7):426–37. Available at: https://doi.org/10.1093/nutrit/nuu016.Google Scholar
Kelly, J. R., Borre, Y., O’ Brien, C., Patterson, E., El Aidy, S., Deane, J., Kennedy, P. J., Beers, S., Scott, K., Moloney, G., Hoban, A. E., Scott, L., Fitzgerald, P., Ross, P., Stanton, C., Clarke, G., Cryan, J. F. & Dinan, T. G. (2016) Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat. Journal of Psychiatric Research 82:109–18. Available at: https://doi.org/10.1016/j.jpsychires.2016.07.019.Google Scholar
Kelsey, C., Dreisbach, C., Alhusen, J. & Grossmann, T. (2019) A primer on investigating the role of the microbiome in brain and cognitive development. Developmental Psychobiology. First published online October 12, 2018. Available at: https://doi.org/10.1002/dev.21778.Google Scholar
Luczynski, P., Neufeld, K. A. M. V., Oriach, C. S., Clarke, G., Dinan, T. G. & Cryan, J. F. (2016) Growing up in a bubble: Using germ-free animals to assess the influence of the gut microbiota on brain and behavior. International Journal of Neuropsychopharmacology 19(8):1–17. Available at: https://doi.org/10.1093/ijnp/pyw020.Google Scholar
Nolvi, S., Uusitupa, H. M., Bridgett, D. J., Pesonen, H., Aatsinki, A. K., Kataja, E. L., Karlsson, H. & Karlsson, L. (2018) Human milk cortisol concentration predicts experimentally induced infant fear reactivity: Moderation by infant sex. Developmental Science 21(4):e12625. Available at: https://doi.org/10.1111/desc.12625.Google Scholar
Pannaraj, P. S., Li, F., Cerini, C., Bender, J. M., Yang, S., Rollie, A., Adisetivo, H., Zabih, S., Lincez, P. J., Bittinger, K., Bailey, A, Bushman, F. D., Sleasman, J. W. & Aldrovandi, G. M. (2017) Association between breast milk bacterial communities and establishment and development of the infant gut microbiome. JAMA Pediatrics 171(7):647–54. Available at: https://doi.org/10.1001/jamapediatrics.2017.0378.Google Scholar
Planer, J. D., Peng, Y., Kau, A. L., Blanton, L. V., Ndao, I. M., Tarr, P. I., Warner, B. B. & Gordon, J. I. (2016) Development of the gut microbiota and mucosal IgA responses in twins and gnotobiotic mice. Nature 534(7606):263–66. Available at: https://doi.org/10.1038/nature17940.Google Scholar
Xia, Y. & Sun, J. (2017) Hypothesis testing and statistical analysis of microbiome. Genes and Diseases 4(3):138–48. Available at: https://doi.org/10.1016/j.gendis.2017.06.001.Google Scholar