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Practical guidelines for gut microbiome analysis in microbiota-gut-brain axis research

Published online by Cambridge University Press:  15 July 2019

Mireia Valles-Colomer Open the ORCID record for Mireia Valles-Colomer [Opens in a new window] ,
Gwen Falony Open the ORCID record for Gwen Falony [Opens in a new window] ,
Sara Vieira-Silva Open the ORCID record for Sara Vieira-Silva [Opens in a new window]  and
Jeroen Raes Open the ORCID record for Jeroen Raes [Opens in a new window]
Mireia Valles-Colomer
Affiliation:
Department of Microbiology, Immunology and Transplantation, KU Leuven, and Center for Microbiology, VIB–KU Leuven, 3000 Leuven, Belgium. mireia.vallescolomer@kuleuven.vib.begwen.falony@kuleuven.vib.besara.vieirasilva@kuleuven.vib.bejeroen.raes@kuleuven.vib.be
Gwen Falony
Affiliation:
Department of Microbiology, Immunology and Transplantation, KU Leuven, and Center for Microbiology, VIB–KU Leuven, 3000 Leuven, Belgium. mireia.vallescolomer@kuleuven.vib.begwen.falony@kuleuven.vib.besara.vieirasilva@kuleuven.vib.bejeroen.raes@kuleuven.vib.be
Sara Vieira-Silva
Affiliation:
Department of Microbiology, Immunology and Transplantation, KU Leuven, and Center for Microbiology, VIB–KU Leuven, 3000 Leuven, Belgium. mireia.vallescolomer@kuleuven.vib.begwen.falony@kuleuven.vib.besara.vieirasilva@kuleuven.vib.bejeroen.raes@kuleuven.vib.be
Jeroen Raes
Affiliation:
Department of Microbiology, Immunology and Transplantation, KU Leuven, and Center for Microbiology, VIB–KU Leuven, 3000 Leuven, Belgium. mireia.vallescolomer@kuleuven.vib.begwen.falony@kuleuven.vib.besara.vieirasilva@kuleuven.vib.bejeroen.raes@kuleuven.vib.be
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Abstract

The microbiota-gut-brain (MGB) axis field is at an exciting stage, but the most recent developments in microbiota research still have to find their way into MGB studies. Here we outline the standards for microbiome data generation, the appropriate statistical techniques, and the covariates that should be included in MGB studies to optimize discovery and translation to clinical applications.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 42 , 2019 , e78
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Copyright
Copyright © Cambridge University Press 2019 

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