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We present a model-independent way to characterise properties of the magnetic-field turbulence in the emitting regions of Gamma-Ray Burst afterglows. Our only assumption is that afterglows’ synchrotron radiation is efficient. It turns out that the gyroradius of plasma particles must be smaller (with a good margin) than the correlation length of the magnetic-field fluctuations. Such turbulence is essentially non-linear and therefore must be produced by some kind of magnetohydrodynamical instability, likely acting on top of kinetic Weibel instability. We also find that the emitting particles are loosely confined to local magnetic-field structures and diffusion allows them to sample the entire distribution of local magnetisation values. This means that one-zone approach to modelling the afterglow spectra is still valid despite the non-linear nature of the magnetic turbulence. However, the non-linear turbulence may (and likely will) change the synchrotron spectrum of individual electrons.
The nature of the first galaxies that reionised the universe during the Epoch of Reionisation (EoR) remains unclear. Attempts to directly determine spectral properties of these early galaxies are affected by both limited photometric constraints across the spectrum and by the opacity of the intergalactic medium to the Lyman Continuum (LyC) at high redshift. We approach this by analysing properties of analogous extreme emission line galaxies (EELGs, [OIII]+Hbeta EW $\gt 400$) at $2.5\lt z\lt 4$ from the ZFOURGE survey using the Multi-wavelength Analysis of Galaxy Physical Properties (MAGPHYS) SED fitting code. We compare these to galaxies at $z \gt 5.5$ observed with the James Webb Space Telesope with self-consistent spectral energy distribution fitting methodology. This work focuses on the comparison of their UV slopes (${\unicode{x03B2}}_P$), ionising photon production efficiencies $\xi_{ion}$, star formation rates and dust properties to determine the effectiveness of this analogue selection technique. We report the median ionising photon production efficiencies as log$_{10}(\xi_{ion}/(Hz\ {\rm erg}^{-1}))=$$25.14^{+0.06}_{-0.04}$, $25.16^{+0.06}_{-0.05}$, $25.16^{+0.04}_{-0.05}$, $25.18^{+0.06}_{-0.07}$ for our ZFOURGE control, ZFOURGE EELG, JADES, and CEERS samples, respectively. ZFOURGE EELGs are 0.57 dex lower in stellar mass and have half the dust extinction, compared to their ZFOURGE control counterparts. They also have a similar specific star formation rates and ${\unicode{x03B2}}_P$ to the $z\gt 5.5$ samples. We find that EELGs at low redshift ($2.5\lt z\lt 4$) are analogous to EoR galaxies in their dust attenuation and specific star formation rates. Their extensive photometric coverage and the accessibility of their LyC region opens pathways to infer stellar population properties in the EoR.
We present and evaluate the prospects for detecting coherent radio counterparts to gravitational wave (GW) events using Murchison Widefield Array (MWA) triggered observations. The MWA rapid-response system, combined with its buffering mode ($\sim$4 min negative latency), enables us to catch any radio signals produced from seconds prior to hours after a binary neutron star (BNS) merger. The large field of view of the MWA ($\sim$$1\,000\,\textrm{deg}^2$ at 120 MHz) and its location under the high sensitivity sky region of the LIGO-Virgo-KAGRA (LVK) detector network, forecast a high chance of being on-target for a GW event. We consider three observing configurations for the MWA to follow up GW BNS merger events, including a single dipole per tile, the full array, and four sub-arrays. We then perform a population synthesis of BNS systems to predict the radio detectable fraction of GW events using these configurations. We find that the configuration with four sub-arrays is the best compromise between sky coverage and sensitivity as it is capable of placing meaningful constraints on the radio emission from 12.6% of GW BNS detections. Based on the timescales of four BNS merger coherent radio emission models, we propose an observing strategy that involves triggering the buffering mode to target coherent signals emitted prior to, during or shortly following the merger, which is then followed by continued recording for up to three hours to target later time post-merger emission. We expect MWA to trigger on $\sim$$5-22$ BNS merger events during the LVK O4 observing run, which could potentially result in two detections of predicted coherent emission.
The Australian SKA Pathfinder (ASKAP) is being used to undertake a campaign to rapidly survey the sky in three frequency bands across its operational spectral range. The first pass of the Rapid ASKAP Continuum Survey (RACS) at 887.5 MHz in the low band has already been completed, with images, visibility datasets, and catalogues made available to the wider astronomical community through the CSIRO ASKAP Science Data Archive (CASDA). This work presents details of the second observing pass in the mid band at 1367.5 MHz, RACS-mid, and associated data release comprising images and visibility datasets covering the whole sky south of $\delta_{\text{J2000}}=+49^\circ$. This data release incorporates selective peeling to reduce artefacts around bright sources, as well as accurately modelled primary beam responses. The Stokes I images reach a median noise of 198 $\mu$Jy PSF$^{-1}$ with a declination-dependent angular resolution of 8.1–47.5 arcsec that fills a niche in the existing ecosystem of large-area astronomical surveys. We also supply Stokes V images after application of a widefield leakage correction, with a median noise of 165 $\mu$Jy PSF$^{-1}$. We find the residual leakage of Stokes I into V to be $\lesssim 0.9$–$2.4$% over the survey. This initial RACS-mid data release will be complemented by a future release comprising catalogues of the survey region. As with other RACS data releases, data products from this release will be made available through CASDA.
The space domain has undergone several changes in the last decade (aka “new space era”), and will continue to do so in coming years. This led to several challenges which should be recognized and tackled by all actors of this domain, including scientists.
The sixth chapter examines the relationship between coutumiers as texts that describe custom, and custom in practice. The difficulty with discussing this is that the coutumiers only begin to be cited in court records at the very end of the thirteenth century and very rarely even then. This was not unusual for the lay courts of northern France in this period, which cited ‘custom’ and not lawbooks or specific precedents. I discuss the relationship between the coutumiers and representations of practice – as filtered through its documentary record-keeping – in two ways. On one level, this chapter shows how at least some people were thinking about court cases that they presided over, took part in, witnessed or heard about. On another, this chapter demonstrates how the coutumier represents practice differently from other remaining records and how coutumier authors used what they saw in practice to extract principles and articulate general rules. Through the coutumiers, we can see how individual actors reshaped specific cases and transactions into general principles, and those general principles into a body of customary law.
A court is said to be the last branch of government because it is the first defence of the individual – individuals rely on the judiciary to protect their rights and freedoms from intrusion by the exercise of public power. Does this apply to the CJEU? Does it protect individuals and Union citizens? To what extent does it act as the ‘third branch’ of government, ensuring that public powers are exercised in the interests of the ‘peoples’ of Europe, or even those people beyond affected by EU law such as the Inuits of Canada? These questions highlight the main themes in this chapter. They can only be partly answered by examining the organisation of the CJEU – its tasks and composition. A fuller answer requires further exploration of the extent to which individuals can access the Court to challenge Union legal acts. This chapter will therefore focus on the two main procedures to bring actions before the CJEU: direct actions via Article 263 TFEU and indirect actions under Article 267 TFEU.
The debate on the compatibility of neutrality with collective security appears to have occupied scholars in the interwar period but not after the end of World War II. However, it remains relevant. Neutrality defers to collective security only if the Charter mechanism works effectively. Even then, however, neutrality is admissible if it does not subvert collective action authorized by the Security Council or the General Assembly under the Uniting-for-Peace resolution.
The aim of this study was to characterize the burden of illness of migraine in Canada. The primary objective was to estimate the annual direct medical resource use and associated costs in migraine patients who failed at least two prophylactic therapies for migraine.
Methods:
Adults with at least four migraine days per month and who had failed at least two prophylactic migraine therapies were included. Participation in a clinical trial within 12 months of enrollment was the sole exclusionary criterion. Patient demographic and clinical characteristics, migraine-related treatment and medical history, and direct medical resource utilization were collected through a retrospective medical chart review. Data on patient characteristics, lifestyle factors, treatments, medical resource utilization, out-of-pocket expenses, and indirect costs were collected through a cross-sectional patient survey. The patient survey also included validated patient-reported outcome instruments to assess migraine impact on quality of life and work productivity loss.
Results:
In total, 287 migraine patients were included. The mean time since migraine diagnosis was 14.3 years and patients experienced a mean of 14.1 migraine days per month. The total estimated annual cost of chronic migraine (CM) was $25,669 per patient, while the annual total costs for high-frequency episodic and low-frequency episodic migraine (EM) were estimated to be $24,885 and $15,651, respectively.
Conclusion:
Migraine is associated with moderate to severe disability. This results in substantial economic burden, directly from healthcare costs such as prescription medications and indirectly through lost work productivity. We also observed that patients with high-frequency EM experience significant burden, similar to that observed for patients with CM.
Xenophon’s interest in the role of elite Athenians in the democratic city is evident not only in his manifestly Athenian works where this is an explicit concern but also elsewhere in his corpus, most notably in his Anabasis, the focus of this chapter. Although this work tells the story of how a band of Greek mercenaries marched with Cyrus into the heart of the Persian Empire in 401 BC, Xenophon’s account is profoundly affected by his Athenian experience and interest in elite political behavior within the Athenian democracy. The Anabasis broadly evokes the political situation in Athens and the complex interactions of mass and elite as Xenophon depicts the importance of and challenges for elite leadership in the quasi-democratic setting of the Cyrean army. In setting forth how a versatile elite Athenian – Xenophon himself – succeeds as a leader of the Cyreans, it confirms in action the principles that Xenophon lays down elsewhere for effective elite leadership within the Athenian democracy. It portrays Xenophon not just as a talented general but as a capable democratic orator who wins over the Cyrean masses in deliberative and forensic contexts that recall their Athenian analogs.
Taking up the definition of a model posited in Chapter 1, models can follow different purposes. This chapter introduces nine general purposes: theory development, generalisation, theory testing, understanding (of systems and their dynamics), explanation (of observed phenomena), prediction (of the system dynamics), decision support (for the derivation of ‘good’ policies and strategies), communication (of knowledge and information) and education (of students and young researchers); and two more technical purposes: integration of knowledge and mediation between scales. These eleven purposes are demonstrated using modelling studies from the literature in the disciplines of physics, ecology and economics. Further, a model may be general or specific, and it may be used for positive analysis (‘what is’) or normative analysis (‘what should be’), or a mixture of both.
The detection of a neutron star merger by the Advanced Laser Interferometer Gravitational-Wave Observatory and Advanced Virgo gravitational wave detectors, and the subsequent detection of an electromagnetic counterpart have opened a new era of transient astronomy. With upgrades to the Advanced Laser Interferometer Gravitational-Wave Observatory and Advanced Virgo detectors and new detectors coming online in Japan and India, neutron star mergers will be detected at a higher rate in the future, starting with the O3 observing run which will begin in early 2019. The detection of electromagnetic emission from these mergers provides vital information about merger parameters and allows independent measurement of the Hubble constant. The Australian Square Kilometre Array Pathfinder is expected to become fully operational in early 2019, and its 30 deg2 field of view will enable us to rapidly survey large areas of sky. In this work we explore prospects for detecting both prompt and long-term radio emission from neutron star mergers with Australian Square Kilometre Array Pathfinder and determine an observing strategy that optimises the use of telescope time. We investigate different strategies to tile the sky with telescope pointings in order to detect radio counterparts with limited observing time, using 475 simulated gravitational wave events. Our results show a significant improvement in observing efficiency when compared with a naïve strategy of covering the entire localisation above some confidence threshold, even when achieving the same total probability covered.
The soluble fms-like tyrosine kinase factor 1 (sFlt-1) is a major contributor to antiangiogenesis during preeclampsia. However, little is known about the effects of sFlt-1 on fetal health. In this study we aim to evaluate the effects of the sFlt-1 concentration during pregnancy on fetal liver physiology. We used adenoviral gene delivery in Sprague-Dawley dams (seven females, 10 weeks old) during mid-gestation (gestational day 8) with adenovirus overexpressing sFlt-1, and age-matched controls (six females, 10 weeks old) with empty adenoviral virus in order to quantify the sFlt-1 concentrations in pregnant dams. Dams exposed to adenoviral sFlt-1 delivery were subdivided into a low (n=4) and high sFlt-1 (n=3) group based on host response to the virus. One-way analysis of variance showed that fetuses (five per dam) exposed to high sFlt-1 concentrations in utero show fetal growth restriction (1.84±0.043 g high sFlt-1 v. 2.32±0.036 g control; mean (M)±s.e.m.; P<0.001), without hypertension or proteinuria in the dams. In continuation, the microarray analysis of the fetal liver of the high sFlt-1 group showed significant enrichment of key genes for fatty acid metabolism and Ppara targets. In addition, using pyrosequencing, we found that the Ppara enrichment in the high sFlt-1 group is accompanied by decreased methylation of its promoter (1.89±0.097 mean % methylation in high sFlt-1 v. 2.26±0.095 mean % methylation in control, M±s.e.m., P<0.02). Our data show that high sFlt-1 concentrations during pregnancy have detrimental effects on the fatty acid metabolism genes and the Ppara targets in the fetal liver.
Williams syndrome is a rare genetic disease that affects elastin production, leading to medium and large vessel stenoses and other abnormalities. Cardiac manifestations of Williams syndrome are the most life-threatening, occurring in 80% of children. Children with Williams syndrome are known to be at risk for sudden cardiac death. These tragic events are often precipitated by diagnostic or therapeutic procedures requiring anaesthesia or sedation, such as cardiac catheterisation. We present the case of a 3-month-old infant with Williams syndrome who suffered sudden cardiac arrest during cardiac catheterisation and subsequent arrest approximately 48 hours after the procedure. We also review the current literature focused on children with Williams syndrome who have suffered sudden cardiac arrest during or after cardiac catheterisation procedures.
According to the Kardashev scale, likely extraterrestrial civilizations above Type-I might use natural energy sources of the Universe, which is also true for transmitting their signals out to distances. A variety of studies have shown that radio pulsars are most likely candidates for this. First, the current study examined how the radio beams of pulsars scan across their environment. Later when the radio beams of pulsars have been modulated, a network model has been proposed on how many habitable planets possible to be home for other assumed advanced civilizations could be reached. It has been found that size of each pulsar's broadcast network depends on the inclination angle. If a civilization controls multiple pulsars, it could comb a considerable fraction of their own celestial sphere and pulsars share their signals in a decentralized fashion as in the mail servers. Moreover, it is briefly cited how beam-modulating mechanisms can be built and searched around pulsars.
Highlights
• It has been shown how pulsars would behave like beacons only when they have been used by modulating their radio signals.
• It has also been indicated how each pulsar could constitute an increasingly growing broadcast network by sweeping geometries and in what way it would emerge as number of controlled pulsars increases.
• It has been interpreted how a modulation mechanism could be established and searched under basic physical principles.
The paper reviews the history of the concepts used to depict poverty in Africa. “Pauperism” is a legal concept, deriving from early modern law in Britain, which frames individual situations, places the paupers under specific rights and duties, and was applied in early colonial situations. Percentile is a economic-demographic concept, implying class difference, indexed to measurable or imputed monetary income, which became an instrument of government in the colonial world mainly after 1945, moving into the international comparative world after the era of independence. In the neoliberal era after 1989, the concept of precarity, and a focus on realizable assets rather than income, has taken higher profile than an emergent replacement for the comparative-percentile approach, sometimes now depicted as “living on $2 a day”. The paper indicates the conceptual and political implications and challenges of each of these depictions.