The University of California (UC) Davis Clinical and Translational Science Center has established the “Join the Team” model, a Clinical Research Coordinator workforce pipeline utilizing a community-based approach. The model has been extensively tested at UC Davis and demonstrated to generate a viable pathway for qualified candidates for employment in clinical research. The model combines the following elements: community outreach; professional training materials created by the Association for Clinical Research Professionals and adapted to the local environment; financial support to trainees to encourage ethnic and socioeconomic diversity; and internship/shadowing opportunities. The program is tailored for academic medical centers (AMCs) in recognition of administrative barriers specific to AMCs. UC Davis’s model can be replicated at other locations using information in this article, such as key program features and barriers faced and surmounted. We also discuss innovative theories for future program iterations.

Following the introduction of the one-child policy in China, the capital-labor ratio of China increased relative to that of India, while FDI/GDP inflows to China versus India simultaneously declined. These observations are explained in the context of a simple neoclassical overlapping generations paradigm. The adjustment mechanism works as follows: the reduction in the growth rate of the (urban) labor force due to the one-child policy increases the capital per worker inherited from the previous generation. The resulting increase in China’s domestic capital-labor ratio thus "crowds out" the need for foreign direct investment (FDI) in China relative to India. Our paper is a contribution to the nascent literature exploring demographic transitions and their effects on FDI flows.

Elastin function is to endow vertebrate tissues with elasticity so that they can adapt to local mechanical constraints. The hydrophobicity and insolubility of the mature elastin polymer have hampered studies of its molecular organisation and structure-elasticity relationships. Nevertheless, a growing number of studies from a broad range of disciplines have provided invaluable insights, and several structural models of elastin have been proposed. However, many questions remain regarding how the primary sequence of elastin (and the soluble precursor tropoelastin) governs the molecular structure, its organisation into a polymeric network, and the mechanical properties of the resulting material. The elasticity of elastin is known to be largely entropic in origin, a property that is understood to arise from both its disordered molecular structure and its hydrophobic character. Despite a high degree of hydrophobicity, elastin does not form compact, water-excluding domains and remains highly disordered. However, elastin contains both stable and labile secondary structure elements. Current models of elastin structure and function are drawn from data collected on tropoelastin and on elastin-like peptides (ELPs) but at the tissue level, elasticity is only achieved after polymerisation of the mature elastin. In tissues, the reticulation of tropoelastin chains in water defines the polymer elastin that bears elasticity. Similarly, ELPs require polymerisation to become elastic. There is considerable interest in elastin especially in the biomaterials and cosmetic fields where ELPs are widely used. This review aims to provide an up-to-date survey of/perspective on current knowledge about the interplay between elastin structure, solvation, and entropic elasticity.

Soil amelioration via strategic deep tillage is occasionally utilized within conservation tillage systems to alleviate soil constraints, but its impact on weed seed burial and subsequent growth within the agronomic system is poorly understood. This study assessed the effects of different strategic deep-tillage practices, including soil loosening (deep ripping), soil mixing (rotary spading), or soil inversion (moldboard plow), on weed seed burial and subsequent weed growth, compared with a no-till control. The tillage practices were applied in 2019 at Yerecoin and Darkan, WA, and data on weed seed burial and growth were collected during the following 3-yr winter crop rotation (2019 to 2021). Soil inversion buried 89% of rigid ryegrass (Lolium rigidum Gaudin) and ripgut brome (Bromus diandrus Roth) seeds to a depth of 10 to 20 cm at both sites, while soil loosening and mixing left between 31% and 91% of the seeds in the top 0 to 10 cm of soil, with broad variation between sites. Few seeds were buried beyond 20 cm despite tillage working depths exceeding 30 cm at both sites. Soil inversion reduced the density of L. rigidum to <1 plant m−2 for 3 yr after strategic tillage. Bromus diandrus density was initially reduced to 0 to 1 plant m−2 by soil inversion, but increased to 4 plants m−2 at Yerecoin in 2020 and 147 plants at Darkan in 2021. Soil loosening or mixing did not consistently decrease weed density. The field data were used to parameterize a model that predicted weed density following strategic tillage with greater accuracy for soil inversion than for loosening or mixing. The findings provide important insights into the effects of strategic deep tillage on weed management in conservational agricultural systems and demonstrate the potential of models for optimizing weed management strategies.

South Africa is a net importer of fertilizer products, importing all of its potassium, as well as 60–70% of its nitrogen requirements. Thus, domestic prices are impacted significantly by international prices, shipping costs, and exchange rates. Producing these fertilizers locally would be far more economical. Phlogopite, a rich source of potassium, is discarded in large quantities during mining operations; the objective of the present study, therefore, was to determine the acid-leaching characteristics and behavior of phlogopite as a means of releasing potassium. Phlogopite samples were leached with nitric acid (source of nitrogen for fertilizers) at various concentrations, temperatures, and reaction times. The feed phlogopite and leached residue samples corresponding to conversions of 14% (LP1), 44% (LP2), and 100% (LP3) were collected and analyzed using X-ray fluorescence spectroscopy (XRF), X-ray diffractometry (XRD), attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), Brunauer–Emmett–Teller surface area and porosity analysis (BET), thermogravimetric analysis (TGA), and field emission gun-scanning electron microscopy (FEG-SEM). The feed phlogopite was highly crystalline. The absence of defects in the lattice meant that the motion of H+ atoms penetrating into the lattice was restricted, suggesting internal diffusion-controlled leaching. Furthermore, results obtained from the various analytical techniques corroborated each other in terms of the release of cations during leaching. All leaching experiments were conducted batchwise, in a closed system. The gravimetric data from the experiments were used to identify a suitable model which predicts accurately the leaching behavior. The reaction was found to be internal diffusion-controlled, and the D1 model, which represents one-dimensional diffusion through a flat plate, predicts the leaching behavior most accurately. The observed activation energies (Ea) and pre-exponential constants (k0) varied with initial nitric acid concentration ([H+]0).

Fe(II)–Fe(III) green rust identified in soil as a natural mineral is responsible for the blue-green color of gley horizons, and exerts the main control on Fe dynamics. A previous EXAFS study of the structure of the mineral confirmed that the mineral belongs to the group of green rusts (GR), but showed that there is a partial substitution of Fe(II) by Mg(II), which leads to the general formula of the mineral: ${[{\text{Fe}}_{1-x}^{2+}{\text{Fe}}_x^{3+}{\text{Mg}}_y{(\text{OH})}_{2+2y}]}^{x+}{[x{\text{OH}}^{-}\cdot m{\text{H}}_2\text{O}]}^{x-}$${[{\rm{Fe}}_{1 - x}^{2 + }{\rm{Fe}}_x^{3 + }{\rm{M}}{{\rm{g}}_y}{({\rm{OH}})_{2 + 2y}}]^{x + }}{[x{\rm{O}}{{\rm{H}}^ - } \cdot m{{\rm{H}}_2}{\rm{O}}]^{x - }}$. The regular binary solid-solution model proposed previously must be extended to ternary, with provision for incorporation of Mg in the mineral. Assuming ideal substitution between Mg(II) and Fe(II), the chemical potential of any Fe(II)-Fe(III)-Mg(II) hydroxy-hydroxide is obtained as: $\text{μ}=X_1{\text{μ}}_{\text{1}}^{\text{o}}+X_2{\text{μ}}_{\text{2}}^{\text{o}}+X_3{\text{μ}}_{\text{3}}^{\text{o}}+\text{R}T[X_1\text{ln}{X}_1+X_2\text{ln}{X}_2+X_3\text{ln}{X}_3]+A_{12}{X}_2(1-X_2)$${\rm{\mu }} = {X_1}{\rm{\mu }}_{\rm{1}}^{\rm{o}} + {X_2}{\rm{\mu }}_{\rm{2}}^{\rm{o}} + {X_3}{\rm{\mu }}_{\rm{3}}^{\rm{o}} + {\rm{R}}T[{X_1}{\rm{ln}}{X_1} + {X_2}{\rm{ln}}{X_2} + {X_3}{\rm{ln}}{X_3}] + {A_{12}}{X_2}(1 - {X_2})$. All experimental data show that the mole ratio X2 = Fe(III)/[Fetotal + Mg] is constrained (1) structurally and (2) geochemically. Structurally, Fe(III) ions cannot neighbor each other, which leads to the inequality $X_2\alpha \raisebox{1ex}{$1$}\!\left/ \!\raisebox{-1ex}{$3$}\right..$${X_2}\leqslant {\raise0.5ex\hbox{$\scriptstyle 1$}\kern-0.1em/\kern-0.15em\lower0.25ex\hbox{$\scriptstyle 3$}}.$ Geochemically, Fe(III) cannot be too remote from each other for GR to form as Fe(OH)2 and Mg(OH)2 are very soluble, so $X_2\alpha \raisebox{1ex}{$1$}\!\left/ \!\raisebox{-1ex}{$4$}\right.$${X_2}\geqslant {\raise0.5ex\hbox{$\scriptstyle 1$}\kern-0.1em/\kern-0.15em\lower0.25ex\hbox{$\scriptstyle 4$}}$. A linear relationship is obtained between the Gibbs free energy of formation of GR, normalized to one Fe atom, and the electronegativity ϰ of the interlayer anion, as: μo/n = −76.887ϰ — 491.5206 (r2 = 0.9985, N = 4), from which the chemical potential of the mineral fougerite μ is obtained in the limiting case X3 = 0, and knowing ${\text{μ}}_{\text{1}}^{\text{o}}=-489.8$${\rm{\mu }}_{\rm{1}}^{\rm{o}} = - 489.8$ kJmol−1 for Fe(OH)2, and ${\text{μ}}_{\text{3}}^{\text{o}}=-832.16$${\rm{\mu }}_{\rm{3}}^{\rm{o}} = - 832.16$ kJmol−1 for Mg(OH)2, the two unknown thermodynamic parameters of the solid-solution model are determined as

${\text{μ}}_{\text{2}}^{\text{o}}=+119.18{\text{kJmol}}^{-1}$${\rm{\mu }}_{\rm{2}}^{\rm{o}} = + 119.18\;{\rm{kJmo}}{{\rm{l}}^{ - 1}}$ for Fe(OH)3 (virtual), and A12 = −1456.28 kJmol−1 (non-ideality parameter). From Mössbauer in situ measurements and our model, the chemical composition of the GR mineral is constrained into a narrow range and the soil solutions-mineral equilibria computed. Soil solutions appear to be largely overstaurated with respect to the two forms observed.

Echinococcus shiquicus is peculiar to the Qinghai–Tibet plateau of China. Research on this parasite has mainly focused on epidemiological surveys and life cycle studies. So far, limited laboratory studies have been reported. Here, experimental infection of E. shiquicus metacestode in BALB/c mice and Mongolian jirds (Meriones unguiculatus) was carried out to establish alternative laboratory animal models. Intraperitoneal inoculation of metacestode material containing protoscoleces (PSCs) obtained from infected plateau pikas were conducted on BALB/c mice. Furthermore, metacestode material without PSCs deriving from infected BALB/c mice was intraperitoneally inoculated to Mongolian jirds. Experimental animals were dissected for macroscopic and histopathological examination. The growth of cysts in BALB/c mice was infiltrative, and they invaded the murine entire body. Most of the metacestode cysts were multicystic, but a few were unilocular. The cysts contained sterile vesicles, which had no PSCs. The metacestode materials were able to successfully infect new mice. In the jirds model, E. shiquicus cysts were typically formed freely in the peritoneal cavity; the majority of these cysts were free while a small portion adhered loosely to nearby organs. The proportion of fertile cysts was high, and contained many PSCs. The PSCs produced in Mongolian jirds also successfully infected new ones, which confirms that jirds can serve as an alternative experimental intermediate host. In conclusion, a laboratory animal infection was successfully established for E. shiquicus using BALB/c mice and Mongolian jirds. These results provide new models for the in-depth study of Echinococcus metacestode survival strategy, host interactions and immune escape mechanism.

Werner’s set-theoretical model is one of the simplest models of CIC. It combines a functional view of predicative universes with a collapsed view of the impredicative sort “ ${\tt Prop}$ ”. However, this model of ${\tt Prop}$ is so coarse that the principle of excluded middle $P \lor \neg P$ holds. Following our previous work, we interpret ${\tt Prop}$ into a topological space (a special case of Heyting algebra) to make the model more intuitionistic without sacrificing simplicity. We improve on that work by providing a full interpretation of dependent product types, using Alexandroff spaces. We also extend our approach to inductive types by adding support for ${\mathsf{list}}$ s.

The surface of the Greenland Ice Sheet is darkening, which accelerates its surface melt. The role of glacier ice algae in reducing surface albedo is widely recognised but not well quantified and the feedbacks between the algae and the weathering crust remain poorly understood. In this letter, we summarise recent advances in the study of the biological darkening of the Greenland Ice Sheet and highlight three key research priorities that are required to better understand and forecast algal-driven melt: (i) identifying the controls on glacier ice algal growth and mortality, (ii) quantifying the spatio-temporal variability in glacier ice algal biomass and processes involved in cell redistribution and (iii) determining the albedo feedbacks between algal biomass and weathering crust characteristics. Addressing these key research priorities will allow us to better understand the supraglacial ice-algal system and to develop an integrated model incorporating the algal and physical controls on ice surface albedo.

Tail biting is a most serious welfare problem in pigs raised for slaughter. In instances of an outbreak of tail biting, scientists have recommended that farmers take measures such as removal of affected animals, provision of enrichment materials and application of repellents to the pigs’ tails. However, no scientific study has ever confirmed the efficacy of any of these suggestions in counteracting an ongoing outbreak. Here, the efficacy of two repellent ointments, Dippel's oil and Stockholm tar, were examined in a tail-chew test. For this, a novel piece of nylon rope was used as a tail model to measure biting behaviour semi-automatically in 24 single-sex groups of growing pigs (total 264 pigs). Repeated measures analysis showed no effect of time, gender or unit (12 pens per unit), but a highly significant effect of treatment, in that both Stockholm tar and Dippel's oil significantly reduced rope manipulation compared to controls. These results suggest that Stockholm tar and Dippel's oil may be effective in reducing tail biting. The approach taken may be valuable in further testing of strategies to reduce tail biting and improving pig welfare.