In this paper, the use of regularization methods to solve the location problem in multilateration systems, using Mode-S signals, is studied, evaluated, and developed. The Tikhonov method has been implemented as a first application to solve the classical system of hyperbolic equations in multilateration systems. Some simulations are obtained and the results are compared with those obtained by the well-established Taylor linearization and with the Cramér–Rao lower bound analysis. Significant improvements, for the accuracy, convergence, and the probability of location, are found for the application of the Tikhonov method.