The cryogenic system for maintaining a target at a constant temperature in the range 5–25 K after shutting off the pulse tube (PT) cryogenic refrigerator is developed and tested. The temperature stability at the sample is ±2 mK for at least 20 hours. The cryogenic setup consists of cryostat, PT cryocooler, liquid helium vessel, helium gas supply, thermo-radiation shield, thermal resistance. The system provides 0.25 W of cooling power at the target. The appropriate thermal resistance should be used for different temperatures. The designed operation mode is 3 minutes off and 15 minutes on. The deactivation of PT cryocooler allows to achieve the target position stability of 1 micrometer or less during the X-ray characterization. The effect of neutron-shield was estimated using Monte-Carlo simulation.