We investigate the link between death rates and smoking prevalence in ten developed countries with the aim of using smoking prevalence data to explain differences in country-specific death rates. A particular problem in building a stochastic mortality model based on smoking prevalence is that there are in general no separate mortality data for smokers and non-smokers available. We show how we can estimate mortality rates for smokers and non-smokers using information about the smoking prevalence in a number of developed countries, and making an additional assumption about the death rates of smokers. We consider this empirical investigation to be the first step towards a consistent mortality model for multiple populations, which will require modelling of country specific differences in mortality, as well as non-smokers’ and smokers’ mortality rates.