The effect of Canada thistle on major yield components of spring wheat was characterized using path coefficient analysis, which provides insight concerning which yield components are most sensitive to Canada thistle competition. Increasing Canada thistle density decreased wheat stand in each of three years. Canada thistle also reduced spikes per plant and seed per spike to varying extents depending on year, but Canada thistle had comparatively little effect on wheat seed weight per 1000 seed. In the path coefficient model proposed, Canada thistle was assumed to reduce yield by directly reducing wheat yield components and through them, indirectly reducing yield. Path coefficient correlation analysis showed that Canada thistle reduced spring wheat yield chiefly by indirect effects of decreasing wheat density, the earliest formed yield component. Canada thistle reduced wheat density which, in turn, reduced wheat yield. These data suggest that Canada thistle must be controlled either before or shortly after wheat emergence if detrimental effects on wheat yield are to be minimized.