Obsessive-compulsive disorder (OCD) has been associated with
frontostriatal abnormality. This has led to the hypothesis that the
disorder is characterized by abnormality of procedural memory. However,
evidence for either procedural or declarative memory disturbance has
been mixed, and few studies have directly assessed both of these forms
of memory in the same patient group. In the present study, we assessed
encoding and retrieval in declarative memory using the Rey Auditory
Verbal Learning Test (RAVLT), and procedural memory using the Pursuit
Rotor Task, in 27 adults with OCD and 29 matched healthy controls.
Groups did not differ with respect to salient demographic
characteristics or memory on the RAVLT. In contrast, patients with OCD
performed significantly better than controls during the early, but not
later trial blocks of the Pursuit Rotor Task. This pattern of results
indicates intact encoding and retrieval in declarative memory, but
abnormally enhanced procedural memory during the early course of
learning in OCD. These findings may be consistent with striatal
overactivation observed in neuroimaging studies of OCD, as well as the
prominent role of the striatum during early stages of procedural
memory. (JINS, 2004, 10, 647–654.)