This introduction presents the two-part Special Issue of honoring the life and work of Amnon Rapoport (1936–2022), a pioneering scholar whose six decades of research shaped experimental studies of interactive decision making. Rapoport’s hallmark was the interplay between formal game-theoretic modeling and rigorous laboratory testing, advancing understanding in coalition formation, social dilemmas, market entry, traffic networks, decision timing, resource dilemmas, behavioral operations, and methodological innovation. The 27 articles collected across the volumes revisit and extend these themes, offering fresh insights into how rationality assumptions succeed and fail in predicting human behavior. Together, the contributions reflect both continuity with Rapoport’s intellectual credo—“model first, test second, refine third”—and renewal through new methods and applications. Beyond scholarship, the issue pays tribute to Rapoport’s extraordinary role as a mentor and his enduring influence on the evolution of behavioral and experimental economics