The paper describes the methodology and computational design strategies used to develop a series of fixed wing micro air vehicles (MAVs) at the Ghent University. The emphasis of the research is to find an optimal MAV-platform that is bound to geometrical constraints but superior in its performance. This requires a multidisciplinary design optimisation but the challenges are mainly of aerodynamic nature. Key areas are endurance, stability, controllability, manoeuvrability and component integration. The highly three-dimensional low Reynolds number flow, the lack of experimental databases and analytical or empirical models of MAV-aerodynamics required fundamental research of the phenomena. This includes the use of a vortex lattice method, three-dimensional CFD-computations and a numerical propeller optimisation method to derive the forces and their derivatives of the MAV and propeller for performance and stability-related optimisation studies. The design method leads to a simple, stable and robust flying wing MAV-platform that has the agility of a fighter airplane. A prototype, the UGMAV25, was constructed and flight tests were performed. The capabilities of the MAV were tested in a series of successful flight manoeuvres. The UGMAV15, a MAV with a span of 15cm, is also developed to test flight-qualities and endurance at this small scale. With the current battery technology, a flight-time of at least one hour is expected.