Violence and the role of violence have emerged recently as topics important to understanding the prehistory of the northern Southwest. Recent excavations at Castle Rock and Sand Canyon pueblos, two thirteenth-century sites in the Mesa Verde region of southwestern Colorado, bring new data to bear on these subjects. Field contexts and the results of bone and myoglobin analyses indicate that nonlethal and lethal violence occurred in both of these villages and that additional modifications to bodies and bones occurred near the time of death. Around A.D. 1280, at least eight individuals at Sand Canyon Pueblo died violently, and at least 41 individuals died at Castle Rock. During or after the warfare event that ended the occupation of Castle Rock, some bodies were dismembered, bones were broken, crushed, and heat altered; a few bones were reamed, and the end of one bone was polished. Several incidents of violence and probable anthropophagy (the consumption of human flesh) have been documented in the Mesa Verde region for the mid-A.D. 1100s; however, this analysis of violent events in the late A.D. 1200s establishes a critical link between probable anthropophagy and warfare, and links both with the depopulation of the region.