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Epigenetic regulation of brain-derived neurotrophic factor: Implications in neurodevelopment and behavior

Published online by Cambridge University Press:  24 October 2012

Benjamin D. Schanker
Benjamin D. Schanker*
Affiliation:
Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02115. bdschanker@gmail.comhttp://www.massgeneral.org/psychiatry/research/pngu_home.aspx
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Abstract

Several recent research findings have implicated brain-derived neurotrophic factor (BDNF) as a mediator of neuronal plasticity. The BDNF gene is under extensive epigenetic regulation, which modulates how much or how little environmental experiences become encoded within neurons and neural circuits. Future scientific progress within the postgenomic paradigm requires elucidation of the functional trajectory in neogenetic and environment interactions.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 35 , Issue 5 , October 2012 , pp. 377 - 378
Copyright
Copyright © Cambridge University Press 2012 

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References

Boulle, F., van den Hove, D. L., Jakob, S. B., Rutten, B. P., Hamon, M., van Os, J., Lesch, K. P., Lanfumey, L., Steinbusch, H. W. & Kenis, G. (2012) Epigenetic regulation of the BDNF gene: Implications for psychiatric disorders. Molecular Psychiatry 17(6):584–96.CrossRefGoogle ScholarPubMed
Branchi, I. (2009) The mouse communal nest: Investigating the epigenetic influences of the early social environment on brain and behavior development. Neuroscience & Biobehavioral Reviews 33(4):551–59.CrossRefGoogle ScholarPubMed
Erickson, K. I., Prakash, R. S., Voss, M. W., Chaddock, L., Heo, S., McLaren, M., Pence, B. D., Martin, S. A., Vieira, V. J., Woods, J. A., McAuley, E. & Kramer, A.F. (2010) Brain-derived neurotrophic factor is associated with age-related decline in hippocampal volume. The Journal of Neuroscience 30(15):5368–75.CrossRefGoogle ScholarPubMed
Fuchikami, M., Morinobu, S., Segawa, M., Okamoto, Y., Yamawaki, S., Ozaki, N., Inoue, T., Kusumi, I., Koyama, T., Tsuchiyama, K. & Terao, T. (2011) DNA methylation profiles of the brain-derived neurotrophic factor (BDNF) gene as a potent diagnostic biomarker in major depression. PLoS One 6(8):e23881.CrossRefGoogle ScholarPubMed
Gomez-Pinilla, F., Zhuang, Y., Feng, J., Ying, Z. & Fan, G. (2011) Exercise impacts brain-derived neurotrophic factor plasticity by engaging mechanisms of epigenetic regulation. The European Journal of Neuroscience 33(3):383–90.CrossRefGoogle ScholarPubMed
Grabe, H. J., Schwahn, C., Mahler, J., Appel, K., Schulz, A., Spitzer, C., Fenske, K., Barnow, S., Freyberger, H. J., Teumer, A., Petersmann, A., Biffar, R., Rosskopf, D., John, U. & Volzke, H. (2012) Genetic epistasis between the brain-derived neurotrophic factor Val66Met polymorphism and the 5-HTT promoter polymorphism moderates the susceptibility to depressive disorders after childhood abuse. Progress in Neuropsychopharmacology and Biological Psychiatry 36(2):264–70.CrossRefGoogle ScholarPubMed
Heldt, S. A., Stanek, L., Chhatwal, J. P. & Ressler, K. J. (2007) Hippocampus-specific deletion of BDNF in adult mice impairs spatial memory and extinction of aversive memories. Molecular Psychiatry 12(7):656–70.CrossRefGoogle ScholarPubMed
Jeanneteau, F. D., Lambert, W. M., Ismaili, N., Bath, K. G., Lee, F. S., Garabedian, M. J. & Chao, M. V. (2012) BDNF and glucocorticoids regulate corticotrophin-releasing hormone (CRH) homeostasis in the hypothalamus. Proceedings of the National Academy of Sciences USA 109(4):1305–10.CrossRefGoogle ScholarPubMed
Keller, S., Sarchiapone, M., Zarrilli, F., Videtic, A., Ferraro, A., Carli, V., Sacchetti, S., Lembo, F., Angiolillo, A., Jovanovic, N., Pisanti, F., Tomaiuolo, R., Monticelli, A., Balazic, J., Roy, A., Marusic, A., Cocozza, S., Fusco, A., Bruni, C. B., Castaldo, G. & Chiariotti, L. (2010) Increased BDNF promoter methylation in the Wernicke area of suicide subjects. Archives of General Psychiatry 67(3):258–67.CrossRefGoogle ScholarPubMed
Montag, C., Markett, S., Basten, U., Stelzel, C., Fiebach, C., Canli, T. & Reuter, M. (2010) Epistasis of the DRD2/ANKK1 Taq Ia and the BDNF Val66Met polymorphism impacts novelty seeking and harm avoidance. Neuropsychopharmacology 35(9):1860–67.CrossRefGoogle ScholarPubMed
Mowla, S. J., Pareek, S., Farhadi, H.F., Petrecca, K., Fawcett, J.P., Seidah, N.G., Morris, S.J., Sossin, W.S. & Murphy, R.A. (1999) Differential sorting of nerve growth factor and brain-derived neurotrophic factor in hippocampal neurons. The Journal of Neuroscience 19(6):2069–80.CrossRefGoogle ScholarPubMed
Rattiner, L. M., Davis, M. & Ressler, K. J. (2004) Differential regulation of brain-derived neurotrophic factor transcripts during the consolidation of fear learning. Learning & Memory 11(6):72731.CrossRefGoogle ScholarPubMed
Roth, T. L. & Sweatt, J. D. (2011) Epigenetic marking of the BDNF gene by early-life adverse experiences. Hormones and Behavior 59(3):315–20.CrossRefGoogle ScholarPubMed
Sen, S., Duman, R. & Sanacora, G. (2008) Serum brain-derived neurotrophic factor, depression, and antidepressant medications: Meta-analyses and implications. Biological Psychiatry 64(6):527–32.CrossRefGoogle ScholarPubMed
Toledo-Rodriguez, M., Lotfipour, S., Leonard, G., Perron, M., Richer, L., Veillette, S., Pausova, Z. & Paus, T. (2010) Maternal smoking during pregnancy is associated with epigenetic modifications of the brain-derived neurotrophic factor-6 exon in adolescent offspring. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics 153B(7):1350–54.CrossRefGoogle ScholarPubMed
Yasuda, S., Liang, M.H., Marinova, Z., Yahyavi, A. & Chuang, D. M. (2009) The mood stabilizers lithium and valproate selectively activate the promoter IV of brain-derived neurotrophic factor in neurons. Molecular Psychiatry 14(1):51–59.CrossRefGoogle ScholarPubMed