Separate studies of rural and urban Head Start systems tested the hypothesis that an emotion-based prevention program (EBP) would accelerate the development of emotion and social competence and decrease agonistic behavior and potential precursors of psychopathology. In both studies, Head Start centers were randomly assigned to treatment and control/comparison group conditions. In Study 1 (rural community), results of hierarchical linear modeling analyses showed that compared to the control condition (Head Start as usual), EBP produced greater increases in emotion knowledge and emotion regulation and greater decreases in children's negative emotion expressions, aggression, anxious/depressed behavior, and negative peer and adult interactions. In Study 2 (inner city), compared to the established prevention program I Can Problem Solve, EBP led to greater increases in emotion knowledge, emotion regulation, positive emotion expression, and social competence. In Study 2, emotion knowledge mediated the effects of EBP on emotion regulation, and emotion competence (an aggregate of emotion knowledge and emotion regulation) mediated the effects of EBP on social competence.

The etiology of early age onset substance use disorder (SUD), an Axis I psychiatric illness, is examined from the perspective of the multifactorial model of complex disorders. Beginning at conception, genetic and environment interactions produce a sequence of biobehavioral phenotypes during development which bias the ontogenetic pathway toward SUD. One pathway to SUD is theorized to emanate from a deviation in somatic and neurological maturation, which, in the context of adverse environments, predisposes to affective and behavioral dysregulation as the cardinal SUD liability-contributing phenotype. Dysregulation progresses via epigenesis from difficult temperament in infancy to conduct problems in childhood to substance use by early adolescence and to severe SUD by young adulthood.

Developmental psychopathology theory speaks to the existence of early-manifesting internalizing problems with a heterogeneous longitudinal course. However, the course of internalizing problems has been investigated largely from late childhood onward, with methods that assume children's problem trajectories vary more so in rate than in qualitative functional form. This can obscure heterogeneity in symptom process and course, obscure onset of early gender differences in internalizing problems, and obscure the relevance of early sociocontextual risks for long-term internalizing outcomes. The present study addressed these issues by using person-oriented (latent growth mixture) methods to model heterogeneity in maternal-reported internalizing symptoms from age 2 to 11 years (N = 1,364). Three latent trajectory classes were supported for each gender: two-thirds of children followed a low-stable trajectory; smaller proportions followed decreasing/increasing or elevated-stable trajectories. Although the number, shape, and predictive validity of internalizing trajectory classes were similar across gender, trajectory classes' initial values and rates of change varied significantly across gender, as did the impact of maternal postpartum depression and anxiety on latent growth factors. Extracted latent trajectories were differentially predicted by postpartum maternal psychopathology, and themselves, in several respects, differentially predicted self-reported depressive symptoms in preadolescence. However, discussion focuses on the need for further external validation of extracted latent classes.The authors thank Daniel J. Bauer for his insightful comments on earlier versions of this manuscript.

Maternal depression has been consistently linked to the development of child problem behavior, particularly in early childhood, but few studies have examined whether reductions in maternal depression serve as a mediator in relation to changes associated with a family-based intervention. The current study addressed this issue with a sample of 731 families receiving services from a national food supplement and nutrition program. Families with toddlers between ages 2 and 3 were screened and then randomized to a brief family intervention, the Family Check-Up, which included linked interventions that were tailored and adapted to the families needs. Follow-up intervention services were provided at age 3 and follow-up of child outcomes occurred at ages 3 and 4. Latent growth models revealed intervention effects for early externalizing and internalizing problems from 2 to 4, and reductions in maternal depression from ages 2 to 3. In addition, reductions in maternal depression mediated improvements in both child externalizing and internalizing problem behavior after accounting for the potential mediating effects of improvements in positive parenting. The results are discussed with respect to targeting maternal depression in future intervention studies aimed at improving early child problem behavior.

Research suggests that exposure to extreme stress in childhood, such as domestic violence, affects children's neurocognitive development, leading to lower intelligence. But studies have been unable to account for genetic influences that might confound the association between domestic violence and lower intelligence. This twin study tested whether domestic violence had environmentally mediated effects on young children's intelligence. Children's IQs were assessed for a population sample of 1116 monozygotic and dizygotic 5-year-old twin pairs in England. Mothers reported their experience of domestic violence in the previous 5 years. Ordinary least squares regression showed that domestic violence was uniquely associated with IQ suppression in a dose–response relationship. Children exposed to high levels of domestic violence had IQs that were, on average, 8 points lower than unexposed children. Structural equation models showed that adult domestic violence accounted for 4% of the variation, on average, in child IQ, independent of latent genetic influences. The findings are consistent with animal experiments and human correlational studies documenting the harmful effects of extreme stress on brain development. Programs that successfully reduce domestic violence should also have beneficial effects on children's cognitive development.

This paper uses a latent class modeling approach to examine gender related variations in offending trajectories from adolescence to young adulthood. This approach is applied to data gathered over the course of a longitudinal study of 896 New Zealand children studied from birth to age 21 years. The analysis identified five trajectory groups: a group of low-risk offenders, three groups of adolescent-limited offenders who varied in the timing of the onset of offending (early, intermediate, and late onset), and a group of chronic offenders. Identical offending trajectories applied for males and females. However, probabilities of trajectory group membership varied with gender, with females being more likely to exhibit low-risk or early onset adolescent-limited offending and males later onset and chronic offending. Examination of social, family, and individual factors associated with these trajectories suggested the presence of a series of common etiological factors relating to family functioning and early adjustment that discriminated between trajectory groups. These risk factors appeared to operate in a similar fashion for both males and females. Implications of these findings for trajectory theories of offending are discussed.

We examined the influence of a common allelic variation in the dopamine receptor D4 (DRD4) gene and caregiver quality on temperament in early childhood. Children 18–21 months of age were genotyped for the DRD4 48 base pair tandem repeat polymorphism, which has been implicated in the development of attention, sensation seeking, and attention-deficit/hyperactivity disorder. The children also interacted with their caregiver for 10 min in a laboratory setting, and these videotaped interactions were coded for parenting quality using an observational rating procedure. The presence of the DRD4 7-repeat allele was associated with differences in the influence of parenting on a measure of temperamental sensation seeking constructed from caregiver reports on children's activity level, impulsivity, and high-intensity pleasure. Children with the 7-repeat allele were influenced by parenting quality, with lower quality parenting associated with higher levels of sensation seeking; children without the 7-repeat allele were uninfluenced by parenting quality. Differences between alleles were not related to the child's self-regulation as assessed by the effortful control measure. Previous studies have indicated that the 7-repeat allele is under positive selective pressure, and our results are consistent with the hypothesis that the DRD4 7-repeat allele increased children's sensitivity to environmental factors such as parenting. This study shows that genes influence the relation between parenting and temperament in ways that are important to normal development and psychopathology.

In a recent meta-analysis, only 53% of disorganized infants were predicted by parental Unresolved states of mind on the Adult Attachment Interview (AAI). The goal of this study was to identify additional predictors of infant disorganization on the AAI by developing and validating an interview-wide coding system for Hostile/Helpless (H/H) parental states of mind with respect to attachment. Maternal AAIs were collected from 45 low-income mothers with high rates of childhood trauma when their children were age 7; Strange Situation assessments had been collected at 18 months of age. AAIs were independently coded using both the Main and Goldwyn coding system and newly developed codes for H/H states of mind. Results indicated that the H/H coding system displayed discriminant validity in that it did not overlap substantially with the Unresolved, Cannot Classify, or Fearfully Preoccupied by Traumatic Events categories in the Main and Goldwyn coding system. Second, H/H states of mind accounted for variance in disorganized infant behavior not associated with the Unresolved classification. Third, H/H states of mind were significantly related to maternal disrupted affective communication as coded by the Atypical Maternal Behavior Instrument for Assessment and Classification coding system, and maternal disrupted communication mediated the relations between H/H states of mind and infant disorganization.

The role of assortative pairing for conduct problems in the continuity of such problems with pervasive social maladaptation in early adulthood was examined in a general population inner-city sample and a high-risk group (young people raised in children's homes). Previous findings showing a switch out of conduct disorder for those in the high-risk group who had supportive cohabiting relationships in early adulthood were replicated in the general population sample, using a latent class analysis. Conduct-disordered individuals, however, were much less likely to attain supportive relationships. The reasons for this lay in a chain of environmental linkages through which conduct-disordered individuals paired assortatively with those who provided less support. This process involved unsatisfactory parenting environments, a lack of planful competence, and the membership of a deviant peer group. Protection afforded by a stable family life, a nondeviant peer group, and planful behavior reduced the risks of assortative pairing. The linking processes appeared to be the same for the general population and the high-risk samples, although having been in the children's homes related to an increased risk of a lack of support, even when the linking processes were taken into account.

The maintenance of high social competence despite stress was examined in a 6-month prospective study of 138 inner-city ninth-grade students. The purpose was to provide a replication and extension of findings derived from previous cross-sectional research involving a comparable sample of children. Specifically, goals were to examine the extent to which high-stress children with superior functioning on one or more aspects of school-based social competence could evade significant difficulties in (a) other spheres of competence at school and (b) emotional adjustment. Measurements of stress were based on uncontrollable negative life events. Competence was assessed via behavioral indices including school grades, teacher ratings, and peer ratings, and emotional distress was measured via self-reports. Results indicated that high-stress children who showed impressive behavioral competence were highly vulnerable to emotional distress over time. Furthermore, almost 85% of the high-stress children who seemed resilient based on at least one domain of social competence at Time 1 had significant difficulties in one or more domains examined when assessed at both Time 1 and Time 2. Findings are discussed in terms of conceptual and empirical issues in resilience research.

Resilience refers to the ability to successfully adapt to stressors, maintaining psychological well-being in the face of adversity. Recent years have seen a great deal of research into the neurobiological and psychological factors and mechanisms that characterize resilient individuals. This article draws from that research to outline some of the most important contributors to resilience. The authors hope that by contributing to a growing understanding of the genetic, developmental, neurobiological, and psychological underpinnings of resilience, researchers and clinicians in the field will move closer toward the goal of identifying and treating individuals at risk for developing posttraumatic psychopathology.

A longitudinal, prospective design was used to examine the roles of peer rejection in middle childhood and antisocial peer involvement in early adolescence in the development of adolescent externalizing behavior problems. Both early starter and late starter pathways were considered. Classroom sociometric interviews from ages 6 through 9 years, adolescent reports of peers' behavior at age 13 years, and parent, teacher, and adolescent self-reports of externalizing behavior problems from age 5 through 14 years were available for 400 adolescents. Results indicate that experiencing peer rejection in elementary school and greater involvement with antisocial peers in early adolescence are correlated but that these peer relationship experiences may represent two different pathways to adolescent externalizing behavior problems. Peer rejection experiences, but not involvement with antisocial peers, predict later externalizing behavior problems when controlling for stability in externalizing behavior. Externalizing problems were most common when rejection was experienced repeatedly. Early externalizing problems did not appear to moderate the relation between peer rejection and later problem behavior. Discussion highlights multiple pathways connecting externalizing behavior problems from early childhood through adolescence with peer relationship experiences in middle childhood and early adolescence.

Chronic, severe irritability is common in childhood and is very impairing. Furthermore, childhood irritability predicts suicidality, social impairment, and depressive and anxiety disorders in adulthood. Focusing on both normative and pathologic development, we review the construct of irritability from its origins in aggression and disruptive behavior research to its contemporary relevance for affective psychopathology. We then describe two broad neurocognitive systems that show promise in differentiating irritable from nonirritable youths: aberrant processing of emotional stimuli and impaired context-sensitive regulation. We suggest behavioral, neurocognitive, and physiologic measures that may aid in studying severe irritability and assessing its therapeutics. Finally, we argue for therapeutic trials targeting severe irritability that address emotional aspects of irritability in addition to the associated disruptive behavior.

Attachment theory has been generating creative and impactful research for almost half a century. In this article we focus on the documented antecedents and consequences of individual differences in infant attachment patterns, suggesting topics for further theoretical clarification, research, clinical interventions, and policy applications. We pay particular attention to the concept of cognitive “working models” and to neural and physiological mechanisms through which early attachment experiences contribute to later functioning. We consider adult caregiving behavior that predicts infant attachment patterns, and the still-mysterious “transmission gap” between parental Adult Attachment Interview classifications and infant Strange Situation classifications. We also review connections between attachment and (a) child psychopathology; (b) neurobiology; (c) health and immune function; (d) empathy, compassion, and altruism; (e) school readiness; and (f) culture. We conclude with clinical–translational and public policy applications of attachment research that could reduce the occurrence and maintenance of insecure attachment during infancy and beyond. Our goal is to inspire researchers to continue advancing the field by finding new ways to tackle long-standing questions and by generating and testing novel hypotheses.

Childhood maltreatment represents a complex stressor, with the developmental timing, duration, frequency, and type of maltreatment varying with each child (Barnett, Manly, & Cicchetti, 1993; Cicchetti & Manly, 2001). Multiple brain regions and neural circuits are disrupted by the experience of child maltreatment (Cicchetti & Toth, in press; DeBellis et al., 2002; McCrory & Viding, 2010; Teicher, Anderson, & Polcari, 2012). These neurobiological compromises indicate the impairment of a number of important cognitive functions, including working memory and inhibitory control. The present study extends prior research by examining the effect of childhood maltreatment on neurocognitive functioning based on developmental timing of maltreatment, including onset, chronicity, and recency, in a sample of 3- to 9-year-old nonmaltreated (n = 136) and maltreated children (n = 223). Maltreated children performed more poorly on inhibitory control and working-memory tasks than did nonmaltreated children. Group differences between maltreated children based on the timing of maltreatment and the chronicity of maltreatment also were evident. Specifically, children who were maltreated during infancy, and children with a chronic history of maltreatment, exhibited significantly poorer inhibitory control and working-memory performance than did children without a history of maltreatment. The results suggest that maltreatment occurring during infancy, a period of major brain organization, disrupts normative structure and function, and these deficits are further instantiated by the prolonged stress of chronic maltreatment during the early years of life.

The capacity to manage emotion is based on the growth of self-regulatory capacities in the early years, but is also affected by situational demands, influences from other people, and the child's goals for regulating emotion in a particular setting. For most children growing up in supportive contexts, the growth of emotional regulation is associated with enhanced psychosocial well-being and socioemotional competence. But for children who are at risk for the development of psychopathology owing to environmental stresses or intrinsic vulnerability (or their interaction), emotional regulation often entails inherent trade-offs that make nonoptimal strategics of managing emotion expectable, perhaps inevitable, in a context of difficult environmental demands and conflicting emotional goals. This analysis discusses how emotional regulation in children at risk may simultaneously foster both resiliency and vulnerability by considering how emotion is managed when children (a) are living with a parent who is depressed, (b) witness or experience domestic violence, or (c) are temperamentally inhibited when encountering novel challenges. In each case, the child's efforts to manage emotion may simultaneously buffer against certain stresses while also enhancing the child's vulnerability to other risks and demands. This double-edged sword of emotional regulation in conditions of risk for children cautions against using “optimal” emotional regulation as an evaluative standard for such children or assuming that emotional regulation necessarily improves psychosocial well-being. It also suggests how the study of emotional regulation must consider the goals for regulating emotion and the contexts in which those goals are sought.

The antecedents and developmental course of borderline personality disorder symptoms were examined prospectively from infancy to adulthood using longitudinal data from a risk sample (N = 162). Borderline personality disorder symptom counts were derived from the Structured Clinical Interview for DSM Disorders diagnostic interview at age 28 years. Correlational analyses confirmed expected relations between borderline symptoms and contemporary adult disturbance (e.g., self-injurious behavior, dissociative symptoms, drug use, relational violence) as well as maltreatment history. Antecedent correlational and regression analyses revealed significant links between borderline symptoms in adulthood and endogenous (i.e., temperament) and environmental (e.g., attachment disorganization, parental hostility) history in early childhood and disturbance across domains of child functioning (e.g., attention, emotion, behavior, relationship, self-representation) in middle childhood/early adolescence. Process analyses revealed a significant mediating effect of self-representation on the relation between attachment disorganization on borderline symptoms. The findings are discussed within a developmental psychopathology framework in which disturbance in self-processes is constructed through successive transactions between the individual and environment.

Semiparametric group-based mixture modeling was used with data from an adolescent school sample (N = 1205) for three purposes. First, five trajectory groups were identified to characterize different patterns of change in the frequency of marijuana use across four waves of assessment during adolescence. These trajectory groups were labeled Abstainers, Experimental Users, Decreasers, Increasers, and High Chronics. Second, trajectory group comparisons were made across eight adolescent risk factors to determine distinctive predictors of the trajectory groups. Findings indicated, for example, that the High Chronic group, relative to the other trajectory groups, had higher levels of delinquency, lower academic performance, more drug using friends, and more stressful life events. Third, adolescent trajectory group comparisons were made across 10 risk behaviors in young adulthood (average subject age = 23.5 years) and the occurrence of psychiatric and substance abuse disorders. Findings indicated some consistency across adolescence to young adulthood with regard to risk factors, and specificity with regard to the prediction of disorders. Adolescent trajectory group membership was significantly associated in young adulthood with cannabis and alcohol disorders but not with major depressive disorders or anxiety disorders.This research was supported by a grant (R37-AA07861) awarded to Michael Windle from the National Institute on Alcohol Abuse and Alcoholism. An earlier version of this article was presented at the Michigan Symposium on Development and Psychopathology: Continuity and Discontinuity during the Transition to Adulthood, Ann Arbor, MI, June 14–15, 2002.

How do exposures to stress affect biobehavioral development and, through it, psychiatric and biomedical disorder? In the health sciences, the allostatic load model provides a widely accepted answer to this question: stress responses, while essential for survival, have negative long-term effects that promote illness. Thus, the benefits of mounting repeated biological responses to threat are traded off against costs to mental and physical health. The adaptive calibration model, an evolutionary–developmental theory of stress–health relations, extends this logic by conceptualizing these trade-offs as decision nodes in allocation of resources. Each decision node influences the next in a chain of resource allocations that become instantiated in the regulatory parameters of stress response systems. Over development, these parameters filter and embed information about key dimensions of environmental stress and support, mediating the organism's openness to environmental inputs, and function to regulate life history strategies to match those dimensions. Drawing on the adaptive calibration model, we propose that consideration of biological fitness trade-offs, as delineated by life history theory, is needed to more fully explain the complex relations between developmental exposures to stress, stress responsivity, behavioral strategies, and health. We conclude that the adaptive calibration model and allostatic load model are only partially complementary and, in some cases, support different approaches to intervention. In the long run, the field may be better served by a model informed by life history theory that addresses the adaptive role of stress response systems in regulating alternative developmental pathways.

Previous studies have documented that smoking during pregnancy (SDP) is associated with offspring externalizing problems, even when measured covariates were used to control for possible confounds. However, the association may be because of nonmeasured environmental and genetic factors that increase risk for offspring externalizing problems. The current project used the National Longitudinal Survey of Youth and their children, ages 4–10 years, to explore the relations between SDP and offspring conduct problems (CPs), oppositional defiant problems (ODPs), and attention-deficit/hyperactivity problems (ADHPs) using methodological and statistical controls for confounds. When offspring were compared to their own siblings who differed in their exposure to prenatal nicotine, there was no effect of SDP on offspring CP and ODP. This suggests that SDP does not have a causal effect on offspring CP and ODP. There was a small association between SDP and ADHP, consistent with a causal effect of SDP, but the magnitude of the association was greatly reduced by methodological and statistical controls. Genetically informed analyses suggest that unmeasured environmental variables influencing both SDP and offspring externalizing behaviors account for the previously observed associations. That is, the current analyses imply that important unidentified environmental factors account for the association between SDP and offspring externalizing problems, not teratogenic effects of SDP.