Hostname: page-component-78c5997874-s2hrs Total loading time: 0 Render date: 2024-11-11T06:10:09.320Z Has data issue: false hasContentIssue false
  • English
  • Français

Viabilidad de la farmacoterapia en trastornos del espectro afectivo relacionados con el VIH: un ensayo abierto con fluvoxamina

Published online by Cambridge University Press:  12 May 2020

P. Perretta ,
C. Nisita ,
E. Zaccagnini ,
C. Lorenzetti ,
A. Nuccorini ,
G. B. Cassano ,
D. M. McNair  and
H. S. Akiskal
P. Perretta
Affiliation:
Clínica Psiquiátrica 1, Universidad de Pisa, Pisa, Italia
C. Nisita
Affiliation:
Clínica Psiquiátrica 1, Universidad de Pisa, Pisa, Italia
E. Zaccagnini
Affiliation:
Clínica Psiquiátrica 1, Universidad de Pisa, Pisa, Italia
C. Lorenzetti
Affiliation:
Clínica Psiquiátrica 1, Universidad de Pisa, Pisa, Italia
A. Nuccorini
Affiliation:
Centro para la Vigilancia del SIDA de Pisa, Pisa, Italia
G. B. Cassano
Affiliation:
Clínica Psiquiátrica 1, Universidad de Pisa, Pisa, Italia
D. M. McNair
Affiliation:
Profesor Emérito, Universidad de Boston, EEUU;
H. S. Akiskal
Affiliation:
Universidad de California en San Diego, San Diego, EEUU
Get access

Resumen

En un estudio abierto, evaluamos la viabilidad de utilizar un antidepresivo serotoninérgico (fluvoxamina) entre pacientes con VIH tratados por trastornos adaptativos, depresivos mayores y otros trastornos afectivos relacionados con el SIDA. Se realizó el seguimiento de 35 pacientes seropositivos (22 hombres y 13 mujeres) con las condiciones anteriores durante un periodo mínimo de cuatro semanas. Al final del tratamiento, un gran número de pacientes (77%) mostraba una mejoría acusada. Los síntomas “nucleares” depresivos y de ansiedad remitieron, mientras que los “somáticos” parecían menos sensibles al tratamiento. El tratamiento tuvo que ser interrumpido prematuramente debido a efectos secundarios en sólo dos pacientes (6%).

Keywords

fluvoxaminatratamientopacientes con VIHtrastornos del espectro afectivotrastorno orgánico del estado de animo
Type
Artículo original
Information
European Psychiatry (Ed. Española) , Volume 3 , Issue 3 , June 1996 , pp. 168 - 174
Copyright
Copyright © European Psychiatric Association 1996

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bibliografia

Abrams, DJDilley, JWMaxey, LMVolberding, PA. Routine care and psychosocial support of the patient with AIDS. Med Clin North Am 1986; 70: 707–20.CrossRefGoogle Scholar
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 3rd ed, rev. Washington, DC: American Psychiatric Association, 1987.Google Scholar
Buhrich, NCoopera, DA and Freed, E. HIV infection associated with symptoms indistinguishable from functional psychosis. Br J Psychiatry 1988; 152: 649–53.CrossRefGoogle ScholarPubMed
Burack, JHBarrett, DCStall, RDChesney, MA. Depressive symptoms and CD4 lymphocite decline among HIV-infected men. JAMA 1993; 270: 2568–73.CrossRefGoogle Scholar
Calabrese, JRKling, MAGold, PV. Alterations in immunocompetence during stress, bereavement, and depression: focus on neuroendocrine regulation. Am J Psychiatry 1987; 144: 1123–34.Google ScholarPubMed
Centers for Disease Control. Update. Acquired Immunodeficiency Syndrome (AIDS). MMWR 1986; 35: 757–60.Google Scholar
Colon, EA. Neuropsychiatric aspects of infection with the human immunodeficiency virus. Curr Opin Psychiatry 1988; 1: 5–12.CrossRefGoogle Scholar
Curran, VHSakulsripron, MLader, M. Antidepressant and human memory: an investigation of four drugs with different sedative and anticholinergic profiles. Psychopharmacology 1988; 95: 520–7.CrossRefGoogle ScholarPubMed
Darko, DFMcCutchan, JAKripke, DFGillin, JCGolshan, S. Fatigue, sleep disturbance, disability, and indices of progression of HIV infection. Am J Psychiatry 1992; 149: 514–20.Google ScholarPubMed
Derix, MMAde Gans, JStam, JPortegies, P. Mental changes in patients with AIDS Clin Neurol Neurosurg 1990; 92: 215–22.CrossRefGoogle ScholarPubMed
Egan, VBrettle, RPGoodwin, GM. The Edinbourgh cohort of HIV-positive drug users: pattem of cognitive impairment in relation to progression of disease. Br J Psychiatry 1992; 161: 522–31.CrossRefGoogle Scholar
Faulstich, ME. Psychiatric aspects of AIDS. Am J Psychiat 1987; 144: 551–6.Google Scholar
Fernández, FAdams, FLevy, JKet al. Cognitive impairmant due to AIDS-related complex and its response to psychostmulants. Psychosomatics 1988; 37: 1235–8.Google Scholar
Fernandez, FLevy, JKMansel, PWA. Response to antidepressant therapy in depressed persons with advanced HIV infection. Anderson Cancer Center, Houston, Texas USA. Poster presented at V intemational conference on AIDS (Montreal) WBP 1989; 191.Google Scholar
Folstein, MFFolstein, SEMac Hugh, PR. Mini Mental State: a practical method for grading the cognitive State of patients for the clinicians. J Psychiat Re 1975; 12: 189–98.CrossRefGoogle Scholar
Gazbuda, DHHo, DDDe La Monte, Smet al.Immunohistochemical identification of HTLV-III antigen in brains of patients with AIDS. Ann Neurology 1986; 20: 289–95.Google Scholar
GIAIDS. Giomale Itaiano dll’AIDS. 1993; 3: 129–39.Google Scholar
Goldberg, RJMor, V. A survey of psychotropic use in terminal cancer patients. Psychosomatics 1986; 26: 745.CrossRefGoogle Scholar
Goodkin, K. Psychiatric disorders in HIV spectrum illness. Texas Medicine 1988; 84: 55–60.Google ScholarPubMed
Lapierre, YDHon, Browne. Treatment of Major Affective Disorders with fluvoxamine. J Clin Psych 1987; 48: 65–8.Google ScholarPubMed
Levine, SHAnderson, DBystritsky, A. The treatment and evaluation of depression in patients infected with HIV. in CME Syllabus and Proceedings Summary, 143rd Annual Meeting of the American Psychiatric Association. Washington, DC: APA, 1990.Google Scholar
Levy, JAScimabukuro, JHollander, HMills, JKaminsky, L. Isolation of AIDS-associated retroviruses from cerebrospinal fluid and brain of patients with neurological symptoms. Lancet 1985; II: 586–8.Google Scholar
Lyketsos, CGHoover, DRGruccione, MSenterfitt, W. Depressive symptoms as predictors of medical outcomes in HIV infections. JAMA 1993; 270: 2563–7.CrossRefGoogle Scholar
Maj, M. Organic mental disorders in HIV-1 infection. AIDS 1990a; 4: 831-40.CrossRefGoogle Scholar
Maj, M. Psychiatric aspects of HIV-1 infection and AIDS. Psychol Med 1990b; 20: 547-63.CrossRefGoogle Scholar
McDonald, EMMann, AHThomas, HC. Interferons as mediators of psychiatric morbidity. An investigation in an trial of recombinant interferon in hepatitis-B carriers. Lancet 1987; 2: 1175–8.CrossRefGoogle Scholar
Munoz, ACarey, VSaah, Aet al. Predictors of decline in CD4 lymphocytes in a cohort of homosexual men infected with human immunodeficency virus. J Acquired Immune Deficiency Syndromes 1988; 1: 396–404.Google Scholar
Ochitil, HDilley, JKohlwes, J. Psychotropic drug prescribing for hospitalized patients with Acquired Immunodeficiency Syndrome. Am J Med 1991; 90: 601–5.CrossRefGoogle Scholar
Overall, JGorham, D. Brief Psychiatric Rating Scale. Psychol Re 1962; 10: 799–822.Google Scholar
Perry, SJacobsen, P. Neuropsychiatric manifestations of AIDS-spectrum disorders. Hospital Community Psychiatry 1986; 37: 135–42.Google ScholarPubMed
Perry, SW. Organic Mental Disorders caused by HIV: update on early diagnosis and treatment. Am J Psychiatry 1990; 147: 696–710.Google ScholarPubMed
Popkin, MCallies, AMackenzie, T. The outcome of antidepressant use in the medically ill. Arch Gen Psychiatry 1985; 42: 1160–3.CrossRefGoogle ScholarPubMed
Rabkin, JGHarrison, MPH and WH. Effect of Imipramine on depression and immune status in a sample of men with HIV infection. Am J Psychiatry 1990; 147: 495–7.Google Scholar
Rosenstein, DLTakeshita, JNelson, JC. Fluoxetine Treatment o f depression in patients with HIV infection. Am J Psychiatry 1991; 148: 6.Google Scholar
Seth, RGranville-Grossman, KGoldmeier, DLynch, S. Psychiatricillness in patients with HIV infection and AIDS referred to the liasison psychiatrists. Br J Psychiatry 1991; 159: 347–50.CrossRefGoogle Scholar
Storch, DD. Caution with use of tricyclics in patients with AIDS. Am J Psychiatry 1991; 148: 12.Google ScholarPubMed
Udelman, DUdelman, H. A preliminary report on antidepressant therapy and its effects on hope and immunity. Soc Sci Med 1985; 20: 1069–72.CrossRefGoogle ScholarPubMed
Wolcott, DLFawzy, FIPasnau, Ro. AIDS and consultation liason psychiatry. Gen Hosp Psychiatry 1986; 8: 7–10.Google Scholar
Wolcott, DL. Psychosocial aspects of acquired immune deficiency syndrome and the primary care physician. Ann Allergy 1986; 57: 95–102.Google ScholarPubMed
Zovy, W. CGI: Clinical Global Impression ECDEU Assessment Manual for Psychopharmacology Revised.DHEW Publication No (ADM). Rockville: National Institute of Mental Health, 1976.Google Scholar