The field of misinformation studies has experienced a boom of scholarship in recent years. Buoyed by the emergence of information operations surrounding the 2016 election and the rise of so-called “fake news,” researchers hailing from fields ranging from philosophy to computer science have taken up the challenge of detecting, analyzing, and theorizing false and misleading information online. In an attempt to understand the spread of misinformation online, researchers have adapted concepts from different disciplines. Concepts from epidemiology, for example, have opened doors to thinking about spread, contagion, and resistance. The life sciences offer concepts and theories to further extend what we know about how misinformation adapts; by viewing information as an organism within a complex ecosystem, we can better understand why some narratives succeed and others fail. Collaborations between misinformation researchers and life scientists to develop responsible adaptations of fitness models can bolster misinformation research.