This study aims to analyze the influence of communication with the mother and father on adolescents’ life satisfaction, as well as possible indirect effects through self-esteem, feelings of loneliness, and perceived classroom environment. These relationships, and possible gender differences, were analyzed in a sample of 1,795 adolescents (52% male, 48% female) aged 11 to 18 years-old (M = 14.2, SD = 1.68), using structural equation modeling. Results indicate a direct effect of communication-mother (girls: β = .19, p < .001; boys: β = .16, p < .05) and communication-father (girls: β = .22, p < .001; boys: β = .17, p < .05) on adolescent life satisfaction; and also indirect effects through self-esteem (communication-mother: girls, β = .18, p < .01; boys: β = .19, p < .05; communication-father: girls: β = .28, p < .001; boys: β = .27, p < .01) and feelings of loneliness (communication-mother: girls: β = -.19, p < .01; boys: β = -.21, p < .05; communication-father: girls: β = -.31, p < .001; boys: β = -.20, p < .01). The results and implications of this study are discussed.