Cox et al's paper addresses an issue that has long been assumed to be a central aspect of brain function – the interplay of different neurotransmitters – but for which we have very little evidence so far. It is currently unclear whether these findings will have implications for the treatment of those with cocaine or other substance dependence.

Supplementary assessment procedures may be used to complement the psychiatric diagnostic interview. These include procedures for the comprehensive evaluation of the mental and physical state of the patient (psychosocial procedures are considered in part 6 (IGDA Workgroup, WPA 2003, this suppl.)). Psychopathological assessment instruments, biological tests and procedures and neuropsychological tests are among those used to enrich or refine data collected in a clinical interview in order to arrive at the standardised multi-axial diagnostic formulation.

Oloyede and colleagues advocate for updating haematological monitoring requirements for clozapine, arguing that current protocols overestimate the risk of clozapine-induced agranulocytosis. Their research suggests that stringent monitoring may unnecessarily limit access to clozapine, a crucial treatment for resistant schizophrenia. The editorial supports calls for international consensus to carefully weigh the pros and cons of relaxing monitoring guidelines while ensuring comprehensive care for patients.