The practical use of ethyl N,N–di–n–propylthiolcarbamate [EPTC] has been studied intensively by weed research workers since introduction of the herbicide in 1957. Early studies were devoted to its evaluation as a soil-surface application for control of germinating weed seed. Studies conducted in 1958 showed that the activity of EPTC could be greatly increased by soil-incorporation immediately after application and emphasis shifted to soil-incorporation research. In general, the accumulated applied research data on the use of EPTC in pre-planting, or lay-by, soil-incorporated treatments have emphasized the pressing need for basic investigations on the effects of soil composition and reaction, temperature, light, moisture, method and depth of incorporation, and method of formulation on the activity of this herbicide. A limited number of basic studies have been conducted on the effects of soil composition and moisture on the performance and persistence of EPTC. However, basic research must be intensified if the excellent herbicidal potentialities of EPTC and other soil-active carbamates are to be utilized to their fullest extent.